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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
| Sáenz, Jaime | CL | Free Agent | 33 | 11/21/1985 | Irvine | USA | Left | Left | 5' 8" | 187 lbs | - |
| Sagar, Sam | LF | Free Agent | 36 | 10/16/1982 | Portmore | JAM | Left | Left | 6' 1" | 220 lbs | - |
| Salas, Justino | 1B | Cleveland Monsters | 23 | 02/17/1995 | Yara | CUB | Left | Left | 6' 0" | 190 lbs | $2,000,000 |
| Salas, Rafael | SS | Baffin Island Beavers | 31 | 08/23/1987 | Country Club | USA | Right | Right | 6' 1" | 193 lbs | $8,850,000 |
| Salazar, José | SP | Los Angeles Bruins | 29 | 11/22/1989 | Vieques | PUR | Right | Right | 6' 2" | 173 lbs | $17,000,000 |
| Salinas, José | MR | Maui Tropics | 23 | 09/03/1995 | Cali | COL | Right | Right | 6' 0" | 235 lbs | $4,000,000 |
| Samurakami, Masamichi | MR | Toronto Titans | 24 | 07/03/1994 | Kanuma | JPN | Right | Right | 5' 10" | 200 lbs | $400,000 |
| Sánchez, Alfredo | 1B | Free Agent | 31 | 03/04/1987 | Santa Clara | CUB | Right | Right | 6' 1" | 213 lbs | - |
| Sánchez, António | RF | St. Louis Browns | 30 | 02/23/1988 | Belle Glade | USA | Left | Left | 5' 9" | 182 lbs | $7,000,000 |
| Sánchez, Félix | CF | San Francisco Bandits | 22 | 05/26/1996 | Trujillo Alto | PUR | Right | Right | 6' 1" | 175 lbs | $400,000 |
| Sánchez, Guillermo | CF | St Charles Sheens | 22 | 09/25/1996 | Mérida | VEN | Right | Right | 6' 2" | 160 lbs | $400,000 |
| Sánchez, Juan | C | Madison Bombers | 23 | 08/22/1995 | Juchitepec | MEX | Right | Right | 6' 0" | 200 lbs | $400,000 |
| Sánchez, Luis | LF | New York Knights | 26 | 10/27/1992 | Fort Scott | USA | Left | Left | 6' 1" | 195 lbs | $7,442,500 |
| Sánchez, Manuel | 1B | Free Agent | 23 | 08/09/1995 | Zapopan | MEX | Right | Right | 6' 2" | 225 lbs | - |
| Sánchez, Ricardo | CL | Indianapolis Lions | 27 | 07/27/1991 | Santiago | CHI | Right | Right | 6' 0" | 205 lbs | $650,000 |
| Sánchez, Wilson | 1B | Free Agent | 32 | 10/26/1986 | North Brunswick Township | USA | Right | Right | 6' 3" | 207 lbs | - |
| Sanders, Joe | 2B | St. Louis Browns | 28 | 09/08/1990 | New York | USA | Left | Right | 5' 8" | 169 lbs | $1,440,000 |
| Sandstrom, Bryan | C | Maui Tropics | 30 | 03/20/1988 | Rohnert Park | USA | Right | Right | 6' 0" | 206 lbs | $8,000,000 |
| Sanford, Porter | LF | Free Agent | 30 | 07/31/1988 | Greeley | USA | Right | Right | 5' 11" | 169 lbs | - |
| Santos, Jesús | RF | Free Agent | 31 | 07/31/1987 | Havana | CUB | Left | Left | 5' 11" | 177 lbs | - |
| Santos, Pedro | SS | Free Agent | 30 | 01/07/1988 | León | MEX | Switch | Right | 6' 2" | 202 lbs | - |
| Sanu, Tomomi | MR | Cleveland Monsters | 32 | 09/11/1986 | Sakado | JPN | Right | Right | 6' 3" | 183 lbs | $5,000,000 |
| Sasaki, Yoshinori | 3B | Free Agent | 32 | 01/19/1986 | Niihama | JPN | Right | Right | 6' 0" | 205 lbs | - |
| Sato, Teruo | SP | Toronto Titans | 24 | 02/24/1994 | Iwanuma | JPN | Right | Right | 6' 4" | 220 lbs | - |
| Saunders, Mike | SP | Kansas City Cougars | 28 | 03/14/1990 | Cherry Hill | USA | Switch | Right | 6' 1" | 225 lbs | - |
| Sawyer, Henry | RF | Los Cabos Cartel | 31 | 02/16/1987 | Charlotte | USA | Right | Right | 5' 11" | 194 lbs | $8,500,000 |
| Schaefer, Drew | MR | Niagara Falls Frenzy | 27 | 04/16/1991 | Casas Adobes | USA | Right | Right | 6' 1" | 226 lbs | $860,000 |
| Schaefer, Greg | SP | Jersey Shore D-Bags | 29 | 07/24/1989 | Douglas | USA | Left | Right | 6' 2" | 240 lbs | $2,460,000 |
| Scholl, Ralph | 3B | New York Knights | 31 | 12/04/1987 | Sartell | USA | Right | Right | 6' 1" | 207 lbs | $7,600,000 |
| Schroeder, Lawrence | SS | Jersey Shore D-Bags | 27 | 07/15/1991 | Fontana | USA | Right | Right | 6' 3" | 227 lbs | $2,060,000 |
| Seals, Clarence | MR | Free Agent | 31 | 05/19/1987 | Ponca City | USA | Switch | Right | 5' 11" | 216 lbs | - |
| Serrano, Raúl | LF | San Francisco Bandits | 30 | 01/04/1988 | Franklin | USA | Right | Right | 6' 1" | 167 lbs | $400,000 |
| Sharp, Rob | LF | Austin River Sharks | 29 | 03/07/1989 | New Haven | USA | Left | Left | 5' 10" | 179 lbs | $12,150,000 |
| Shaw, Stephen | 2B | New Orleans Looters | 26 | 12/30/1992 | Boston | USA | Right | Right | 6' 0" | 190 lbs | $400,000 |
| Shelton, Ron | 1B | New York Knights | 24 | 01/18/1994 | Pittsboro | USA | Right | Right | 6' 0" | 215 lbs | $400,000 |
| Shibutani, Koshiro | MR | Toronto Titans | 33 | 07/12/1985 | Niigata | JPN | Left | Left | 6' 0" | 210 lbs | $900,000 |
| Si-ma, Li-xue | SP | Maui Tropics | 23 | 09/18/1995 | Taipei | TPE | Left | Left | 6' 2" | 235 lbs | $400,000 |
| Silva, Luis | MR | Madison Bombers | 27 | 07/21/1991 | Izúcar | MEX | Left | Right | 6' 6" | 210 lbs | - |
| Silva, Ramón | CL | Kansas City Cougars | 24 | 06/24/1994 | Havana | CUB | Right | Right | 6' 3" | 215 lbs | $1,160,000 |
| Simmons, Justin | SS | San Francisco Bandits | 30 | 07/06/1988 | Portland | USA | Right | Right | 6' 0" | 190 lbs | $400,000 |
| Sinclair, Dylan | 2B | Austin River Sharks | 31 | 05/14/1987 | Carolina | PUR | Left | Right | 6' 1" | 204 lbs | $2,010,000 |
| Skinner, Mike | SP | Free Agent | 37 | 12/25/1981 | Boulder | USA | Left | Right | 5' 10" | 195 lbs | - |
| Smith, Bob | RF | Free Agent | 23 | 02/26/1995 | Spencer | USA | Switch | Right | 6' 1" | 165 lbs | - |
| Smith, Brian | 1B | St. Louis Browns | 30 | 12/17/1988 | New York | USA | Right | Left | 6' 0" | 243 lbs | $2,400,000 |
| Smith, Grant | 1B | New York Knights | 26 | 06/29/1992 | Toms River | USA | Left | Left | 6' 2" | 215 lbs | $400,000 |
| Smith, Joey | MR | Indianapolis Lions | 33 | 12/29/1985 | Union Hill-Novelty Hill | USA | Left | Left | 6' 1" | 216 lbs | $1,200,000 |
| Smith, Stephen | SS | San Francisco Bandits | 33 | 07/01/1985 | Matoaca | USA | Right | Right | 6' 2" | 187 lbs | $3,500,000 |
| Smith, Tommy | CL | Hendersonville Hitmen | 33 | 07/12/1985 | Spokane | USA | Right | Right | 6' 2" | 229 lbs | $4,000,000 |
| Snider, Lynn | 2B | New York Knights | 27 | 05/28/1991 | New York | USA | Right | Right | 5' 11" | 222 lbs | - |
| So, Byung-soo | RF | Free Agent | 33 | 12/11/1985 | Changwon | KOR | Right | Right | 6' 0" | 184 lbs | - |
| Solís, Diego | MR | Toronto Titans | 32 | 03/22/1986 | Brooklyn | USA | Right | Right | 6' 2" | 187 lbs | $6,000,000 |
| Solís, Manuel | SS | New Orleans Looters | 30 | 09/13/1988 | Tuscaloosa | USA | Right | Right | 6' 3" | 195 lbs | $4,515,000 |
| Spencer, Chris | SP | Toronto Titans | 24 | 06/16/1994 | Pearl City | USA | Right | Right | 6' 7" | 225 lbs | $400,000 |
| St-Pierre, Jean-Paul | SS | Chicago Machine | 23 | 12/25/1995 | Ottawa | CAN | Right | Right | 6' 3" | 190 lbs | - |
| Stanford, Kenny | MR | Free Agent | 35 | 12/19/1983 | Deltona | USA | Right | Right | 6' 2" | 164 lbs | - |
| Stevens, Howard | MR | Boston Rebels | 32 | 03/01/1986 | New York | USA | Right | Right | 6' 0" | 179 lbs | $3,000,000 |
| Stokes, Robert | 3B | Maui Tropics | 31 | 08/17/1987 | Macomb | USA | Right | Right | 5' 8" | 203 lbs | $850,000 |
| Stokes, Ryan | LF | Free Agent | 31 | 06/25/1987 | Federal Way | USA | Left | Left | 6' 0" | 183 lbs | - |
| Stricker, John | MR | Free Agent | 34 | 12/09/1984 | Memphis | USA | Left | Left | 5' 10" | 182 lbs | - |
| Sturdy, Mark | MR | Boston Rebels | 30 | 08/10/1988 | Lubbock | USA | Right | Right | 5' 10" | 206 lbs | $750,000 |
| Subgua, Aluizio | SP | St Charles Sheens | 30 | 09/25/1988 | Porto Alegre | BRA | Switch | Right | 6' 5" | 223 lbs | $656,000 |
| Sugimoto, Suezo | RF | Los Angeles Bruins | 24 | 06/03/1994 | Tokyo | JPN | Switch | Left | 6' 3" | 218 lbs | $1,750,000 |
| Sugiyama, Susumu | SS | Reno Cards | 22 | 09/04/1996 | Toyohashi | JPN | Right | Right | 6' 1" | 180 lbs | $400,000 |
| Suzuki, Keitaro | SS | New York Knights | 22 | 11/09/1996 | Anjo | JPN | Right | Right | 6' 1" | 160 lbs | $650,000 |
| Suzuki, Soh | SP | Baffin Island Beavers | 25 | 07/28/1993 | Daito | JPN | Right | Right | 6' 2" | 230 lbs | - |
