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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
| Eager, Ron | SP | Austin River Sharks | 29 | 12/15/1989 | Winnipeg | CAN | Switch | Right | 6' 2" | 212 lbs | $5,700,000 |
| Edgar, Jim | 2B | St Charles Sheens | 24 | 05/10/1994 | Billings | USA | Right | Right | 6' 1" | 195 lbs | - |
| Edwards, David | MR | Kansas City Cougars | 34 | 05/03/1984 | La Grange | USA | Right | Right | 6' 2" | 205 lbs | $925,000 |
| Edwards, Gordon | 2B | Cleveland Monsters | 29 | 11/19/1989 | Glendale | USA | Left | Right | 6' 1" | 199 lbs | $2,000,000 |
| Ellis, Art | SP | Jersey Shore D-Bags | 33 | 11/06/1985 | El Cajon | USA | Right | Right | 6' 1" | 206 lbs | $11,600,000 |
| Ellis, Donald | CF | Free Agent | 36 | 05/22/1982 | Madison | USA | Left | Right | 6' 3" | 176 lbs | - |
| Ellison, Randy | SP | Hendersonville Hitmen | 33 | 11/01/1985 | Glen Cove | USA | Right | Right | 6' 5" | 212 lbs | $1,200,000 |
| Émond, Samuel | SP | Chicago Machine | 22 | 12/07/1996 | Ottawa | CAN | Right | Right | 6' 4" | 285 lbs | - |
| Encarnación, Miguel | SS | Seattle Pikes | 23 | 03/14/1995 | Tucupita | VEN | Right | Right | 5' 9" | 180 lbs | $1,500,000 |
| Endo, Yajirobei | SP | Reno Cards | 23 | 08/04/1995 | Komaki | JPN | Right | Right | 6' 6" | 225 lbs | $1,810,000 |
| Er, Hua | RF | Free Agent | 32 | 04/04/1986 | Tainan | TPE | Right | Right | 6' 3" | 192 lbs | - |
| Escobedo, Gerardo | 3B | Kansas City Cougars | 21 | 08/29/1997 | San Juan | PUR | Right | Right | 6' 3" | 210 lbs | $400,000 |
| Esparza, José | CF | Irvine Gang Green | 26 | 03/24/1992 | Bismarck | USA | Left | Left | 6' 2" | 182 lbs | $400,000 |
| Espinoza, Luis | RF | Chicago Machine | 22 | 12/29/1996 | Tapachula | MEX | Left | Left | 6' 1" | 190 lbs | - |
| Estes, Erik | MR | Reno Cards | 29 | 06/27/1989 | Murrieta Hot Springs | USA | Right | Right | 6' 2" | 212 lbs | $1,390,000 |
| Estrada, José | LF | St. Louis Browns | 30 | 02/05/1988 | New York | USA | Switch | Right | 6' 1" | 192 lbs | $20,000,000 |
| Estrada, José | CF | Cleveland Monsters | 35 | 04/02/1983 | Valdese | USA | Left | Left | 5' 11" | 207 lbs | $800,000 |
| Estrada, Manny | MR | Boston Rebels | 32 | 08/14/1986 | Jones Creek | USA | Right | Right | 6' 1" | 190 lbs | $820,000 |
| Estrada, Ramón | SP | Hendersonville Hitmen | 22 | 11/22/1996 | Canóvanas | PUR | Right | Right | 6' 5" | 255 lbs | $400,000 |
| Estrada, Tomás | RF | St Charles Sheens | 22 | 12/25/1996 | Mexico City | MEX | Right | Right | 5' 9" | 170 lbs | - |
| Evans, David | SP | Kansas City Cougars | 31 | 08/04/1987 | New York | USA | Left | Left | 6' 3" | 226 lbs | $2,070,000 |
