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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sa, Zhu | C | St. Louis Coeur | 30 | 06/04/2025 | Yuanli | TPE | Switch | Right | 6' 1" | 200 lbs | $280,000 |
| Sahagún, Júlio | 1B | Montana Pandas | 35 | 11/23/2020 | El Estor | GUA | Right | Right | 6' 1" | 200 lbs | $280,000 |
| Saikawa, Matsusuke | 1B | Free Agent | 30 | 06/26/2025 | Chofu | JPN | Left | Left | 6' 4" | 195 lbs | - |
| Salazar, Andrés | SP | Free Agent | 24 | 03/12/2031 | Lufkin | USA | Right | Right | 6' 3" | 200 lbs | - |
| Sandison, Len | CF | Seattle Rocketeers | 33 | 10/13/2022 | Marion | USA | Left | Left | 6' 0" | 200 lbs | $1,000,000 |
| Sandoval, Miguel | SP | Buffalo White Walkers | 16 | 09/03/2039 | Zacatecas | MEX | Right | Right | 6' 1" | 170 lbs | - |
| Santamarina, Doug | SP | St. Louis Coeur | 28 | 06/11/2027 | Belize | BLZ | Switch | Right | 6' 4" | 200 lbs | $10,500,000 |
| Santos, José | SS | Buffalo White Walkers | 31 | 01/01/2024 | Santo Domingo | DOM | Switch | Right | 6' 1" | 200 lbs | $1,160,000 |
| Santos, Pepe | 1B | New Orleans Voodoo | 23 | 06/22/2032 | Pedro Brand | DOM | Left | Left | 6' 8" | 200 lbs | $280,000 |
| Saunders, Joe | CF | St. Louis Coeur | 25 | 07/24/2030 | Sanford | USA | Left | Left | 6' 0" | 200 lbs | $280,000 |
| Scarlett, Cliff | RP | Ft. Worth Cattlemen | 27 | 03/23/2028 | Saskatoon | CAN | Right | Right | 6' 3" | 200 lbs | $280,000 |
| Scharf, Craig | 1B | Free Agent | 22 | 03/22/2033 | Sandwich | USA | Left | Left | 6' 2" | 200 lbs | - |
| Serrano, Adrián | C | Ft. Worth Cattlemen | 33 | 04/07/2022 | San Pedro de Macorís | DOM | Right | Right | 6' 0" | 205 lbs | $1,300,000 |
| Shimizu, Sumitomo | 2B | Vancouver Grey Wolves | 28 | 01/09/2027 | Kitakyushu | JPN | Right | Right | 5' 9" | 180 lbs | $280,000 |
| Shini, Yaichiro | SP | Vancouver Grey Wolves | 31 | 09/27/2024 | Kashihara | JPN | Right | Right | 6' 6" | 200 lbs | $5,700,000 |
| Shirt, Robert | SP | Free Agent | 32 | 12/05/2023 | Spanish Town | JAM | Right | Right | 5' 11" | 200 lbs | - |
| Simpson, Kent | SP | Free Agent | 23 | 02/01/2032 | Murfreesboro | USA | Left | Left | 6' 4" | 200 lbs | - |
| Slooters, Peer | SP | Athletic Club KC | 37 | 01/10/2018 | Willemstad | CUR | Right | Right | 6' 4" | 195 lbs | $16,300,000 |
| Snijders, Walter | CF | Boston Patriots | 16 | 11/08/2039 | Parakai | NZL | Right | Left | 5' 10" | 155 lbs | - |
| Soliman, Nestor | C | Ft. Worth Cattlemen | 31 | 08/21/2024 | Maragondon | PHI | Right | Right | 6' 2" | 200 lbs | $7,200,000 |
| Son, Kyung-chul | 2B | New Orleans Voodoo | 31 | 12/03/2024 | Seoul | KOR | Left | Right | 6' 0" | 185 lbs | $17,500,000 |
| Sosa, Emílio | SP | Ft. Worth Cattlemen | 16 | 06/27/2039 | San Juan de la Maguana | DOM | Right | Right | 6' 0" | 165 lbs | - |
| Sosa, Salvador | SP | Free Agent | 33 | 08/19/2022 | New York | USA | Right | Left | 6' 0" | 200 lbs | - |
| Souza, Jorge | SP | Vancouver Grey Wolves | 35 | 09/01/2020 | Villa Vazquez | DOM | Right | Right | 6' 1" | 205 lbs | $22,000,000 |
| Spencer, William | RP | Athletic Club KC | 26 | 11/10/2029 | Boston | USA | Switch | Right | 6' 1" | 205 lbs | $280,000 |
| Spillman, Bill | SS | Vancouver Grey Wolves | 26 | 07/01/2029 | Chicago | USA | Switch | Right | 6' 0" | 200 lbs | $280,000 |
| Stansberry, Darryl | CF | Buffalo White Walkers | 24 | 09/17/2031 | San Francisco | USA | Right | Right | 6' 2" | 200 lbs | $280,000 |
| Stockton, Andrew | RP | Panama City Piranhas | 27 | 09/08/2028 | Bodmin | ENG | Left | Left | 6' 3" | 200 lbs | $539,000 |
| Strong, Tim | RP | New Orleans Voodoo | 32 | 02/16/2023 | Quincy | USA | Left | Left | 6' 4" | 205 lbs | $3,500,000 |
| Sulander, Antti-Jussi | RF | Seattle Rocketeers | 26 | 04/17/2029 | Kiskorös | HUN | Left | Left | 6' 1" | 190 lbs | $1,850,000 |
| Sundararajan, Nanda | SP | Montana Pandas | 17 | 10/31/2038 | Nagpur | IND | Switch | Right | 6' 8" | 200 lbs | - |
| Suzuki, Yoshi | RP | Free Agent | 23 | 11/01/2032 | Sambu | JPN | Switch | Right | 6' 4" | 200 lbs | - |
| Swan, Ishaan | LF | Panama City Piranhas | 29 | 01/07/2026 | St. George | BER | Left | Right | 6' 0" | 185 lbs | $13,400,100 |
| Sánchez, Luis | RP | Free Agent | 22 | 08/21/2033 | La Descubierta | DOM | Right | Right | 6' 7" | 200 lbs | - |
