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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sa, Zhu | C | Northville Eclipse | 25 | 06/04/2025 | Yuanli | TPE | Switch | Right | 6' 1" | 200 lbs | - |
| Samelo, Bayani | SP | Free Agent | 29 | 03/10/2021 | Iloilo | PHI | Right | Right | 6' 2" | 195 lbs | - |
| Samuels, George | SS | Westwood Sixshooters | 29 | 10/28/2021 | Arnold | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sandoval, Fernando | RP | Marquette Miners | 28 | 03/12/2022 | Turrialba | CRC | Right | Right | 6' 2" | 190 lbs | - |
| Sang, Yang-cheng | SP | Ottawa Nationals | 28 | 03/05/2022 | Liaoyuan | CHN | Left | Left | 6' 6" | 205 lbs | - |
| Santos, Jorge | RP | Lancaster Farmers | 23 | 06/23/2027 | San Miguel | CRC | Left | Left | 6' 3" | 185 lbs | - |
| Sapinoso, Juan | RF | Asheville Highlanders | 28 | 05/27/2022 | Puerto Plata | DOM | Left | Left | 6' 1" | 195 lbs | - |
| Schmidt, Robin | 1B | Tacoma Fur Traders | 25 | 11/06/2025 | Waseca | USA | Right | Right | 6' 0" | 200 lbs | - |
| Schmitt, Damien | SP | Billings Polar Bears | 23 | 11/15/2027 | Civrieux-dAzergues | FRA | Right | Right | 6' 8" | 200 lbs | - |
| Scott, Curt | 3B | Free Agent | 26 | 10/03/2024 | Twin Falls | USA | Left | Right | 5' 10" | 200 lbs | - |
| Scott, Johnny | 2B | Ottawa Nationals | 27 | 01/19/2023 | Orlando | USA | Right | Right | 6' 4" | 205 lbs | - |
| Scott, Yu-bao | SP | Yakima Hops | 25 | 06/29/2025 | Toowoomba | AUS | Right | Right | 6' 1" | 200 lbs | - |
| Seema, Shu-yaan | 3B | Westwood Sixshooters | 29 | 11/13/2021 | Saigong | HKG | Right | Right | 6' 4" | 200 lbs | - |
| Segar, Evan | 1B | Asheville Highlanders | 25 | 07/20/2025 | Kingston | JAM | Left | Left | 6' 1" | 200 lbs | - |
| Serevi, Manu | RP | Free Agent | 17 | 06/14/2033 | Vailoatai | ASA | Right | Right | 6' 2" | 180 lbs | - |
| Sergeant, Colm | 2B | Ottawa Nationals | 25 | 07/18/2025 | Charlotte Amalie | VIR | Right | Right | 6' 2" | 195 lbs | - |
| Shannon, Kevin | RP | Tacoma Fur Traders | 25 | 01/29/2025 | Evansville | USA | Right | Right | 6' 2" | 200 lbs | - |
| Silva, Tony | 2B | Toledo Saboteurs | 28 | 05/16/2022 | Cleveland | USA | Right | Right | 6' 0" | 200 lbs | - |
| Simmons, Tim | SP | Ottawa Nationals | 27 | 01/03/2023 | Chicago | USA | Right | Right | 5' 9" | 180 lbs | - |
| Simon, Allen | SP | Westwood Sixshooters | 27 | 03/23/2023 | Miamisburg | USA | Right | Left | 6' 2" | 200 lbs | - |
| Sims, Mark | SP | Free Agent | 24 | 10/18/2026 | West Palm Beach | USA | Right | Right | 6' 2" | 195 lbs | - |
| Smith, Andrew | RF | Marquette Miners | 22 | 07/12/2028 | New River | USA | Left | Left | 6' 6" | 200 lbs | - |
| Smith, Artie | CF | Ottawa Nationals | 26 | 10/19/2024 | South San Jose Hills | USA | Left | Left | 6' 4" | 200 lbs | - |
| Smith, Brandon | C | Ottawa Nationals | 25 | 04/21/2025 | Pflugerville | USA | Right | Right | 6' 1" | 200 lbs | - |
| Song, Sun-jae | CF | Casper Ghosts | 24 | 06/18/2026 | Namyangju | KOR | Right | Right | 6' 0" | 180 lbs | - |
| Soto, Ángel | C | Westwood Sixshooters | 28 | 10/12/2022 | Aucayacu | PER | Right | Right | 6' 2" | 200 lbs | - |
| Sparrow, Sean | C | Irving Blue Sox | 25 | 05/22/2025 | Sioux Falls | USA | Left | Right | 6' 0" | 200 lbs | - |
| Spilsbury, Zachary | C | Toledo Saboteurs | 23 | 07/27/2027 | London | ENG | Right | Right | 6' 1" | 200 lbs | - |
| Stewart, Coy | RP | Asheville Highlanders | 26 | 06/23/2024 | Redford Township | USA | Right | Right | 6' 2" | 195 lbs | - |
| Stockton, Andrew | SP | Asheville Highlanders | 22 | 09/08/2028 | Bodmin | ENG | Left | Left | 6' 3" | 195 lbs | - |
| Stokes, Edward | CF | Tacoma Fur Traders | 25 | 07/20/2025 | Hoffman Estates | USA | Right | Right | 6' 2" | 200 lbs | - |
| Stone, Kevin | RP | Ottawa Nationals | 25 | 04/26/2025 | Brookfield | USA | Right | Right | 5' 10" | 185 lbs | - |
| Surber, Brian | RP | Free Agent | 24 | 01/25/2026 | Tuba City | USA | Right | Right | 6' 3" | 200 lbs | - |
| Sáenz, António | SS | Yakima Hops | 22 | 03/27/2028 | Enriquillo | DOM | Left | Right | 6' 0" | 175 lbs | - |
| Sánchez, Arturo | RP | Marquette Miners | 28 | 10/27/2022 | Chilibre | PAN | Right | Right | 6' 2" | 200 lbs | - |
