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| Friday, November 4th , 2050 |
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| Asheville Highlanders: Signed Manager Don Thomas. |
| Wednesday, October 26th , 2050 |
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| Billings Polar Bears: Fired Hitting Coach Habbo Allaart. |
| Friday, October 21st , 2050 |
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| Irving Blue Sox: RP Mike Kuhlman retired from professional baseball. |
| Irving Blue Sox: SP Joe Vogel retired from professional baseball. |
| Irving Blue Sox: LF Cal Ewing retired from professional baseball. |
| Casper Ghosts: C Sozui Amano retired from professional baseball. |
| Toledo Saboteurs: C Pancho Achio retired from professional baseball. |
| Ottawa Nationals: RF Cam Lloyd retired from professional baseball. |
| Irving Blue Sox: CF Ron Buchanan retired from professional baseball. |
| Toledo Saboteurs: 1B Frank Curry retired from professional baseball. |
| Marquette Miners: RP Aaron Rigsby retired from professional baseball. |
| Casper Ghosts: RF Bernard Cornwell retired from professional baseball. |
| Toledo Saboteurs: 1B Ralph Brantley retired from professional baseball. |
| Irving Blue Sox: LF Shane Holman retired from professional baseball. |
| Marquette Miners: LF Nick Thomas retired from professional baseball. |
| Lancaster Farmers: LF Roland Matthews retired from professional baseball. |
| Lancaster Farmers: 2B Konrad Velthuizen retired from professional baseball. |
| Billings Polar Bears: CF Nick Seymour retired from professional baseball. |
| Lancaster Farmers: 2B Randy Copeland retired from professional baseball. |
| Tacoma Fur Traders: Released RP Claudio Dávila. |
| Tacoma Fur Traders: Released RP Manny Martínez. |
| Tacoma Fur Traders: Released RP Don Lucas. |
| Tacoma Fur Traders: Released RP Nobuatsu Toshishai. |
| Tacoma Fur Traders: Released CF Gabriel Gonzáles. |
| Lancaster Farmers: Manager Tracy Williams retires. |
| Irving Blue Sox: Hitting Coach Martin Richards leaves the team, his contract was not renewed |
| Casper Ghosts: Hitting Coach Ji-chol Yang leaves the team, his contract was not renewed |
| Casper Ghosts: Manager Mesa Altuve leaves the team, his contract was not renewed |
| Casper Ghosts: Pitching Coach Ken Burton leaves the team, his contract was not renewed |
| Asheville Highlanders: Pitching Coach Melvin Henry leaves the team, his contract was not renewed |
| Asheville Highlanders: Manager Carlos Pérez leaves the team, his contract was not renewed |
| Marquette Miners: Signed Hitting Coach Marvin Hayes to a 2-year contract extension. |
| Billings Polar Bears: Manager Marvin Nelson leaves the team, his contract was not renewed |
| Saturday, September 24th , 2050 |
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| Marquette Miners: Activated RP Dermott Kalman from the injured list. |
| Westwood Sixshooters: Manager Cedric Fields retires. |
| Northville Eclipse: Activated SS Rob Robinson from the injured list. |
