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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sackett, John | SP | Pontiac Godfathers | 21 | 04/27/2029 | Birmingham | USA | Right | Right | 6' 6" | 200 lbs | - |
| Sanders, Henry | SS | Rocky Mountain Vibes | 23 | 07/14/2027 | Kansas City | USA | Right | Right | 6' 0" | 190 lbs | - |
| Sanford, Steve | SP | Pontiac Godfathers | 20 | 07/21/2030 | Forest Park | USA | Right | Right | 6' 1" | 180 lbs | - |
| Sang, Jung-jun | DH | Columbia River Rats | 23 | 10/06/2027 | Uijeongbu | KOR | Left | Left | 6' 4" | 200 lbs | - |
| Santos, Juan | CF | Columbia River Rats | 22 | 03/02/2028 | León | NCA | Right | Right | 6' 0" | 165 lbs | - |
| Sato, Shingen | SS | Mancelona Torch | 22 | 01/19/2028 | Gifu | JPN | Right | Right | 6' 2" | 190 lbs | - |
| Scallini, Francisco | C | Put-In-Bay Commodores | 23 | 06/06/2027 | Santa Teresa | VEN | Right | Right | 6' 0" | 200 lbs | - |
| Sellars, Anthony | RP | Columbia River Rats | 22 | 09/01/2028 | San Antonio | USA | Left | Left | 6' 2" | 195 lbs | - |
| Shaffer, Nelson | RP | Grand Forks Caterpillars | 21 | 01/18/2029 | Meridian | USA | Switch | Right | 6' 3" | 195 lbs | - |
| Si, Wei-kang | RP | Alameda Airmen | 23 | 06/20/2027 | Sun City West | USA | Right | Right | 6' 6" | 220 lbs | - |
| Silva, Alberto | CF | Belleville Bulls | 22 | 04/09/2028 | Charallave | VEN | Right | Right | 6' 1" | 170 lbs | - |
| Simha, Balanatha | 3B | Pontiac Godfathers | 19 | 02/03/2031 | Pune Cantonment | IND | Right | Right | 6' 3" | 185 lbs | - |
| Simon, Claude | RP | Belleville Bulls | 23 | 12/18/2027 | Burnaby | CAN | Right | Right | 6' 4" | 200 lbs | - |
| Skenandore, August | RF | Columbia River Rats | 23 | 12/09/2027 | Diggle | ENG | Right | Right | 6' 1" | 195 lbs | - |
| Sloan, Ray | RF | Belleville Bulls | 23 | 04/16/2027 | New York | USA | Left | Left | 6' 0" | 195 lbs | - |
| Snyder, Jason | 1B | Grand Forks Caterpillars | 22 | 03/11/2028 | New York | USA | Right | Right | 6' 2" | 210 lbs | - |
| Son, Hyo-jin | SP | Rocky Mountain Vibes | 22 | 06/11/2028 | Jincheon | KOR | Left | Left | 6' 4" | 185 lbs | - |
| Sosa, Claudio | 2B | Niagara Falls Expos | 21 | 10/21/2029 | Santiago | DOM | Left | Right | 6' 1" | 190 lbs | - |
| Spivey, Kenneth | 2B | Rocky Mountain Vibes | 24 | 07/02/2026 | White Oak | USA | Right | Right | 6' 1" | 190 lbs | - |
| Stenis, Andre | LF | Alameda Airmen | 22 | 04/14/2028 | Rincon | ANT | Right | Right | 6' 5" | 200 lbs | - |
| Stewart, Winston | 3B | Washington Generals | 22 | 05/20/2028 | Alexandria | USA | Right | Right | 6' 0" | 185 lbs | - |
| Suzuki, Yeijiro | RF | Free Agent | 23 | 04/29/2027 | Sanjo | JPN | Right | Right | 6' 2" | 195 lbs | - |
| Suárez, Víctor | 3B | Belleville Bulls | 22 | 01/06/2028 | East San Gabriel | USA | Right | Right | 6' 2" | 195 lbs | - |
| Sánchez, Ramón | SP | Mancelona Torch | 19 | 09/11/2031 | Puerto la Cruz | VEN | Left | Left | 6' 2" | 185 lbs | - |
