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| Sunday, October 23rd , 2050 |
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| Grand Forks Caterpillars: Signed Manager Steve Ferguson. |
| Friday, October 21st , 2050 |
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| Rocky Mountain Vibes: RP Tomás Dávila retired from professional baseball. |
| Mancelona Torch: 3B Sam Ávila retired from professional baseball. |
| Columbia River Rats: RF Simon N. Garfunkle retired from professional baseball. |
| Columbia River Rats: RP José Herradón retired from professional baseball. |
| Belleville Bulls: SP Arthur Sánchez retired from professional baseball. |
| Syracuse Storm: Pitching Coach Don Thomas leaves the team, his contract was not renewed |
| Mancelona Torch: Hitting Coach Michael Peterson leaves the team, his contract was not renewed |
| Mancelona Torch: Pitching Coach Tony Garza leaves the team, his contract was not renewed |
| Mancelona Torch: Manager Bernardo Hernández leaves the team, his contract was not renewed |
| Columbia River Rats: Hitting Coach Salvador Vidal leaves the team, his contract was not renewed |
| Rocky Mountain Vibes: Manager Mal Green leaves the team, his contract was not renewed |
| Put-In-Bay Commodores: Fired Pitching Coach Ángel Ruíz. |
| Put-In-Bay Commodores: Fired Hitting Coach Sergio Martínez. |
| Monday, September 26th , 2050 |
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| Washington Generals: Released RP Jesse Larson. |
| Tuesday, September 20th , 2050 |
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| Pontiac Godfathers: Placed 3B Balanatha Simha on the active roster. |
| Alameda Airmen: Placed SS Conrad Hickey on the active roster. |
| Niagara Falls Expos: Placed SP Kai-ge Yo on the active roster. |
| Tuesday, September 13th , 2050 |
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| Washington Generals: Activated RP Marcos Toro from the injured list. |
| Washington Generals: Activated SP Domingo Delgado from the injured list. |
| Put-In-Bay Commodores: Activated SP Gerardo Tobías from the injured list. |
| Caldwell Chiefs: Activated RP David Hayes from the injured list. |
| Washington Generals: Released RP Jaime Morales. |
