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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sanders, Henry | SS | Rocky Mountain Vibes | 22 | 07/14/2027 | Kansas City | USA | Right | Right | 6' 0" | 185 lbs | - |
| Sang, Jung-jun | LF | Columbia River Rats | 22 | 10/06/2027 | Uijeongbu | KOR | Left | Left | 6' 4" | 200 lbs | - |
| Santos, Jorge | RP | Niagara Falls Expos | 22 | 06/23/2027 | San Miguel | CRC | Left | Left | 6' 3" | 185 lbs | - |
| Santos, Juan | CF | Columbia River Rats | 21 | 03/02/2028 | León | NCA | Right | Right | 6' 0" | 165 lbs | - |
| Scallini, Francisco | C | Put-In-Bay Commodores | 22 | 06/06/2027 | Santa Teresa | VEN | Right | Right | 6' 0" | 200 lbs | - |
| Schmidt, Robin | 1B | Washington Generals | 24 | 11/06/2025 | Waseca | USA | Right | Right | 6' 0" | 200 lbs | - |
| Seah, Kien-lung | C | Columbia River Rats | 20 | 03/23/2029 | Shenyang | CHN | Right | Right | 6' 1" | 200 lbs | - |
| Sergeant, Colm | 2B | Belleville Bulls | 24 | 07/18/2025 | Charlotte Amalie | VIR | Right | Right | 6' 2" | 195 lbs | - |
| Seymour, Nick | CF | Grand Forks Caterpillars | 24 | 10/07/2025 | Vicksburg | USA | Left | Left | 5' 11" | 200 lbs | - |
| Shantsev, Jov | 1B | Monroeville Yinzers | 21 | 07/23/2028 | Moscow | RUS | Right | Right | 6' 0" | 195 lbs | - |
| Smith, Andrew | RF | Put-In-Bay Commodores | 21 | 07/12/2028 | New River | USA | Left | Left | 6' 6" | 200 lbs | - |
| Smith, Greg | 1B | Syracuse Storm | 22 | 08/18/2027 | Johnson | USA | Right | Right | 6' 4" | 215 lbs | - |
| Song, Sun-jae | CF | Mancelona Torch | 23 | 06/18/2026 | Namyangju | KOR | Right | Right | 6' 0" | 175 lbs | - |
| Sparrow, Sean | C | Free Agent | 24 | 05/22/2025 | Sioux Falls | USA | Left | Right | 6' 0" | 200 lbs | - |
| Spivey, Kenneth | 2B | Rocky Mountain Vibes | 23 | 07/02/2026 | White Oak | USA | Right | Right | 6' 1" | 185 lbs | - |
| Stewart, Winston | 3B | Washington Generals | 21 | 05/20/2028 | Alexandria | USA | Right | Right | 6' 0" | 190 lbs | - |
| Stockton, Andrew | SP | Columbia River Rats | 21 | 09/08/2028 | Bodmin | ENG | Left | Left | 6' 3" | 190 lbs | - |
| Stone, Kevin | RP | Belleville Bulls | 24 | 04/26/2025 | Brookfield | USA | Right | Right | 5' 10" | 185 lbs | - |
| Suzuki, Yeijiro | CF | Belleville Bulls | 22 | 04/29/2027 | Sanjo | JPN | Right | Right | 6' 2" | 190 lbs | - |
| Sáenz, António | SS | Alameda Airmen | 21 | 03/27/2028 | Enriquillo | DOM | Left | Right | 6' 0" | 170 lbs | - |
| Sánchez, Arthur | SP | Belleville Bulls | 24 | 07/21/2025 | Staten Island | USA | Right | Right | 5' 10" | 195 lbs | - |
