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| Thursday, November 11th , 2049 |
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| Belleville Bulls: Signed Manager Steve Bryan. |
| Monday, November 1st , 2049 |
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| Syracuse Storm: Signed Manager Vincent Hall. |
| Sunday, October 24th , 2049 |
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| Monroeville Yinzers: 3B Miguel García retired from professional baseball. |
| Syracuse Storm: LF Clayton Peters retired from professional baseball. |
| Mancelona Torch: SS Joe Jans retired from professional baseball. |
| Put-In-Bay Commodores: 2B Arturo Valéncia retired from professional baseball. |
| Mancelona Torch: 2B Chris Norman retired from professional baseball. |
| Rocky Mountain Vibes: RP Larry Ayala retired from professional baseball. |
| Rocky Mountain Vibes: SS Jon Kuhn retired from professional baseball. |
| Alameda Airmen: Pitching Coach Woody Cook retires. |
| Alameda Airmen: Hitting Coach Mario Zuziela leaves the team, his contract was not renewed |
| Syracuse Storm: Signed Pitching Coach Asad Shihab to a 2-year contract extension. |
| Belleville Bulls: Hitting Coach Michael Messer leaves the team, his contract was not renewed |
| Belleville Bulls: Manager Edward Whipp leaves the team, his contract was not renewed |
| Belleville Bulls: Pitching Coach Mike Wilson leaves the team, his contract was not renewed |
| Put-In-Bay Commodores: Signed Pitching Coach Ángel Ruíz to a 2-year contract extension. |
| Put-In-Bay Commodores: Signed Hitting Coach Sergio Martínez to a 2-year contract extension. |
| Grand Forks Caterpillars: Pitching Coach Vikas Bhaskar leaves the team, his contract was not renewed |
| Saturday, September 11th , 2049 |
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| Syracuse Storm: Activated SP Caden Hickman from the injured list. |
| Washington Generals: Activated CF Bo McCoy from the injured list. |
| Niagara Falls Expos: Hitting Coach Darrel Berry retires. |
