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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sachs, Eddie | 1B | Philadelphia 1776 BC | 30 | 09/27/2007 | Allentown | USA | Right | Right | 6' 2" | 250 lbs | $5,640,000 |
| Sainz, Eduardo | C | Boston Patriots | 17 | 11/06/2020 | Santa Ana | CRC | Right | Right | 6' 0" | 185 lbs | - |
| Salas, Alberto | CF | Vancouver Grey Wolves | 33 | 05/23/2004 | Cardenas | CUB | Right | Right | 5' 10" | 185 lbs | $280,000 |
| Salas, Nelson | SP | Free Agent | 19 | 01/15/2018 | West Hempstead | USA | Switch | Right | 6' 4" | 195 lbs | - |
| Salazar, Paco | RP | Charleston Battery | 27 | 02/09/2010 | Clawson | USA | Left | Left | 6' 4" | 215 lbs | $1,578,750 |
| Salgado, Alonso | LF | Free Agent | 18 | 03/03/2019 | Vernon | USA | Right | Right | 6' 3" | 200 lbs | - |
| Salinas, Juan | SP | Free Agent | 20 | 08/10/2017 | Aibonito | PUR | Left | Right | 6' 1" | 175 lbs | - |
| Samelo, Bayani | SP | St. Louis Coeur | 16 | 03/10/2021 | Iloilo | PHI | Right | Right | 6' 2" | 170 lbs | - |
| Sánchez, Arturo | SP | St. Louis Coeur | 16 | 04/02/2021 | La Romana | DOM | Right | Right | 5' 11" | 160 lbs | - |
| Sánchez, José | RP | Free Agent | 26 | 11/28/2011 | Nashville | USA | Right | Right | 6' 4" | 215 lbs | - |
| Sánchez, José | RP | Boston Patriots | 34 | 10/09/2003 | David | PAN | Left | Left | 6' 4" | 205 lbs | $800,000 |
| Sánchez, Juan | SP | Boston Patriots | 26 | 07/22/2011 | Santo Domingo | DOM | Right | Right | 6' 3" | 180 lbs | $280,000 |
| Sánchez, Manuel | RP | Boston Patriots | 26 | 11/19/2011 | Songo-La Maya | CUB | Left | Right | 6' 0" | 210 lbs | $1,640,000 |
| Sánchez, Miguel | SP | Free Agent | 23 | 11/21/2014 | Macon | USA | Right | Right | 5' 9" | 165 lbs | - |
| Sánchez, Ramón | RP | Free Agent | 20 | 03/09/2017 | Lake Los Angeles | USA | Right | Left | 5' 10" | 170 lbs | - |
| Sánchez, Roberto | RP | Free Agent | 24 | 03/17/2013 | Brentwood | USA | Left | Left | 6' 2" | 205 lbs | - |
| Sanders, Chris | SP | Free Agent | 23 | 11/05/2014 | Security-Widefield | USA | Right | Right | 6' 1" | 195 lbs | - |
| Sanders, Larry | SP | Free Agent | 21 | 10/06/2016 | Jackson Township | USA | Switch | Right | 5' 10" | 175 lbs | - |
| Sangrey, Thomas | SP | Free Agent | 18 | 03/29/2019 | Madison | USA | Right | Right | 5' 10" | 165 lbs | - |
| Santana, Rubén | SP | Free Agent | 18 | 06/03/2019 | Hartshorne | USA | Switch | Right | 6' 4" | 195 lbs | - |
| Santángel, Juan Esteban | RF | Buckhead Bowties | 17 | 11/15/2020 | Panuco | MEX | Right | Left | 6' 2" | 190 lbs | - |
| Santos, José | SS | St. Louis Coeur | 28 | 06/17/2009 | Carora | VEN | Right | Right | 6' 2" | 210 lbs | $470,000 |
| Sargent, Damon | SP | Free Agent | 22 | 03/24/2015 | Eveleth | USA | Right | Right | 5' 11" | 180 lbs | - |
| Sawyer, Andy | RP | Free Agent | 24 | 06/24/2013 | New York | USA | Right | Right | 6' 8" | 240 lbs | - |
| Schaefer, John | LF | Portland Evergreens | 29 | 03/19/2008 | Cincinnati | USA | Left | Left | 6' 2" | 230 lbs | $825,000 |
| Schalk, Norbert | 2B | New Orleans Voodoo | 17 | 06/01/2020 | Willemstad | CUR | Right | Right | 6' 0" | 165 lbs | - |
| Schmidt, Garland | RP | Free Agent | 27 | 04/14/2010 | Chapel Hill | USA | Right | Right | 6' 1" | 215 lbs | - |
| Schock, Justin | 3B | Free Agent | 17 | 06/21/2020 | Palm Bay | USA | Right | Right | 6' 3" | 190 lbs | - |
| Scott, Chris | RP | Free Agent | 26 | 07/28/2011 | Whetstone | USA | Left | Left | 6' 4" | 210 lbs | - |
| Scott, Morton | 2B | Free Agent | 18 | 01/29/2019 | Paris | USA | Right | Right | 6' 0" | 170 lbs | - |
| Seals, Jeff | SP | Free Agent | 20 | 12/28/2017 | Chino Valley | USA | Right | Right | 6' 4" | 195 lbs | - |
| Seco, Jesús | C | Free Agent | 27 | 12/08/2010 | South Bay | USA | Right | Right | 6' 0" | 200 lbs | - |
| Sekine, Tsukasa | LF | St. Louis Coeur | 36 | 11/27/2001 | Ono | JPN | Right | Right | 6' 2" | 220 lbs | $14,000,000 |
| Sellers, Cameron | SP | Free Agent | 21 | 07/22/2016 | Pasco | USA | Right | Right | 6' 1" | 200 lbs | - |
| Semprún, Carlos | SP | Portland Evergreens | 17 | 03/04/2020 | Santo Domingo | DOM | Left | Left | 6' 4" | 190 lbs | - |
| Semprún, Ramón | SS | Portland Evergreens | 18 | 07/29/2019 | Catia La Mar | VEN | Right | Right | 5' 11" | 165 lbs | - |
| Sen, Hu | 2B | St. Louis Coeur | 16 | 01/24/2021 | Urumqi | CHN | Right | Right | 6' 2" | 180 lbs | - |
| Shades, Sanford | SP | Free Agent | 21 | 09/21/2016 | Inver Grove Heights | USA | Right | Right | 6' 2" | 205 lbs | - |
| Shaffer, Thurman | C | Free Agent | 18 | 04/04/2019 | Odessa | USA | Right | Right | 6' 2" | 215 lbs | - |
| Shamburger, Turner | RP | Charleston Battery | 26 | 08/05/2011 | Bronx | USA | Right | Right | 6' 2" | 205 lbs | $1,100,000 |
| Shannon, Rob | CF | Free Agent | 21 | 12/19/2016 | Birmingham | USA | Right | Right | 6' 0" | 175 lbs | - |
| Shaw, Bobby | SP | Free Agent | 19 | 10/17/2018 | Parkwood | USA | Right | Right | 6' 1" | 180 lbs | - |
| Sheffield, Charles | 2B | Free Agent | 21 | 11/11/2016 | Pueblo | USA | Right | Right | 6' 2" | 190 lbs | - |
| Shelton, Garrett | SP | Free Agent | 21 | 05/14/2016 | Tampa | USA | Left | Left | 6' 0" | 185 lbs | - |
| Shepard, Colton | C | Free Agent | 17 | 02/01/2020 | Bensenville | USA | Right | Right | 6' 3" | 190 lbs | - |
| Shive, Fredrick | SP | Free Agent | 19 | 09/19/2018 | North Ogden | USA | Right | Right | 6' 1" | 185 lbs | - |
| Shortall, Rod | LF | St. Louis Coeur | 27 | 12/01/2010 | Saint-Jérôme | CAN | Right | Right | 6' 1" | 195 lbs | $280,000 |
| Siddall, John | SS | Free Agent | 21 | 05/22/2016 | Brampton | CAN | Right | Right | 6' 4" | 200 lbs | - |
| Silva, António | C | Cleveland Browns | 18 | 11/05/2019 | Los Botados | DOM | Right | Right | 6' 2" | 205 lbs | - |
| Silva, Germán | SP | Buckhead Bowties | 17 | 09/20/2020 | Santo Domingo | DOM | Right | Right | 5' 10" | 155 lbs | - |
| Simmons, Lance | SP | Free Agent | 18 | 09/20/2019 | Sunnyvale | USA | Left | Left | 6' 1" | 180 lbs | - |
| Simpson, Jeff | LF | Boston Patriots | 31 | 08/24/2006 | Belton | USA | Left | Right | 6' 0" | 220 lbs | $16,150,000 |
| Sin, Sang-mok | SP | Northern Virginia Rainbow Mermaids | 20 | 10/07/2017 | Seoul | KOR | Left | Right | 6' 4" | 195 lbs | - |
| Sinclair, Max | RF | Free Agent | 18 | 02/21/2019 | North Canton | USA | Left | Left | 6' 0" | 170 lbs | - |
| Sipe, José | RP | Las Vegas Flamingos | 28 | 03/21/2009 | Lebanon | USA | Switch | Left | 6' 5" | 225 lbs | $1,000,000 |
| Sirtoni, Greyson | SP | Free Agent | 23 | 06/02/2014 | Quebec City | CAN | Right | Right | 6' 7" | 230 lbs | - |
| Skinner, Jason | SP | Free Agent | 20 | 09/02/2017 | Monongahela | USA | Right | Right | 5' 10" | 175 lbs | - |
| Skipworth, Ray | DH | Vancouver Grey Wolves | 31 | 04/12/2006 | Milford | USA | Right | Right | 6' 2" | 210 lbs | $2,600,000 |
| Slaugh, Bryan | SP | Free Agent | 22 | 05/18/2015 | Draper | USA | Left | Right | 6' 2" | 185 lbs | - |
| Sloan, Clarence | C | Free Agent | 18 | 07/11/2019 | Tampa | USA | Right | Right | 6' 0" | 195 lbs | - |
| Smith, Jeffery | CF | Free Agent | 18 | 08/03/2019 | Los Angeles | USA | Left | Left | 6' 0" | 180 lbs | - |
| Smith, Josh | SP | Free Agent | 17 | 02/16/2020 | Villas | USA | Right | Left | 6' 2" | 185 lbs | - |
| Smith, Micheal | SP | Free Agent | 18 | 03/02/2019 | Los Angeles | USA | Right | Right | 5' 11" | 170 lbs | - |
| Smith, Mike | SP | Free Agent | 21 | 10/21/2016 | Rochester | USA | Right | Right | 6' 2" | 200 lbs | - |
| Smythe, Patrick | SP | Free Agent | 22 | 01/16/2015 | Los Angeles | USA | Right | Right | 6' 2" | 200 lbs | - |
| Solís, Carlos | C | Portland Evergreens | 19 | 12/30/2018 | Santo Domingo | DOM | Right | Right | 6' 4" | 205 lbs | - |
| Solís, Jeff | 2B | Portland Evergreens | 27 | 07/19/2010 | Collinsville | USA | Right | Right | 5' 10" | 185 lbs | $280,000 |
| Soriano, José | C | Free Agent | 18 | 07/31/2019 | Juigalpa | NCA | Right | Right | 6' 0" | 185 lbs | - |
| Sosa, Francisco | SP | New Orleans Voodoo | 16 | 09/08/2021 | Villa de Sonador | DOM | Right | Right | 6' 2" | 175 lbs | - |
| Sosa, Francisco | RP | Free Agent | 26 | 03/11/2011 | Columbia | USA | Left | Right | 6' 1" | 205 lbs | - |
| Soto, Rafael | 3B | St. Louis Coeur | 17 | 01/05/2020 | Villa Alemana | CHI | Left | Right | 5' 9" | 160 lbs | - |
| Sparks, Clyde | SP | Free Agent | 21 | 05/07/2016 | Casper | USA | Right | Right | 6' 0" | 185 lbs | - |
| Spillane, Bren | SS | Chicago Silver Sox | 24 | 02/19/2013 | Versailles | USA | Switch | Right | 6' 1" | 180 lbs | $280,000 |
| St. John, John | SP | Free Agent | 21 | 04/09/2016 | Scott | USA | Switch | Right | 6' 0" | 185 lbs | - |
| Stafford, Zach | 3B | Free Agent | 17 | 01/20/2020 | Buffalo | USA | Right | Right | 6' 3" | 185 lbs | - |
| Stanley, Forest | SP | Chicago Silver Sox | 27 | 06/27/2010 | Bartlesville | USA | Switch | Right | 6' 3" | 200 lbs | $2,000,000 |
| Stanley, José | SP | Free Agent | 21 | 05/11/2016 | Corvallis | USA | Right | Right | 6' 11" | 250 lbs | - |
| Starr, Mac | 2B | Free Agent | 19 | 04/12/2018 | Fairland | USA | Right | Right | 6' 1" | 180 lbs | - |
| Sterrenburg, Edward | 2B | Boston Patriots | 26 | 02/07/2011 | Willemstad | CUR | Switch | Right | 6' 4" | 200 lbs | $5,250,000 |
| Stevens, John | SP | Free Agent | 18 | 04/15/2019 | Porcupine | CAN | Right | Right | 6' 0" | 180 lbs | - |
| Stevens, Mike | CF | Free Agent | 22 | 12/13/2015 | Mesa | USA | Left | Left | 6' 0" | 190 lbs | - |
| Stewart, Steve | 1B | Free Agent | 23 | 11/03/2014 | Red Hill | USA | Right | Right | 6' 0" | 200 lbs | - |
| Stinson, Tim | C | Greenville 84s | 29 | 03/29/2008 | Presidential Lakes Estates | USA | Left | Right | 6' 0" | 225 lbs | $14,375,000 |
| Stockhill, Glen | CF | Buckhead Bowties | 18 | 07/01/2019 | London | ENG | Right | Right | 6' 0" | 170 lbs | - |
| Stoger, August | C | Philadelphia 1776 BC | 17 | 10/24/2020 | Steyr | AUT | Right | Right | 6' 3" | 200 lbs | - |
| Storan, Joe | RF | Free Agent | 19 | 07/16/2018 | Memphis | USA | Switch | Left | 6' 5" | 210 lbs | - |
| Stottlar, Blaine | SP | Greenville 84s | 31 | 08/10/2006 | Gleed | USA | Switch | Right | 6' 4" | 220 lbs | $8,600,000 |
| Stout, Chris | SP | Free Agent | 18 | 06/27/2019 | Seattle | USA | Left | Right | 6' 3" | 195 lbs | - |
| Suárez, Roberto | C | D.C. Divided | 17 | 04/13/2020 | Buenos Aires | ARG | Right | Right | 6' 4" | 215 lbs | - |
| Sugimoto, Kuniyuki | SP | New Orleans Voodoo | 17 | 02/15/2020 | Toyonaka | JPN | Right | Right | 6' 3" | 190 lbs | - |
| Sullivan, Dave | C | Free Agent | 21 | 06/26/2016 | Arlington | USA | Switch | Right | 6' 2" | 215 lbs | - |
| Sullivan, Geoff | 2B | Free Agent | 18 | 11/16/2019 | Madison Heights | USA | Right | Right | 6' 1" | 180 lbs | - |
| Summers, Hunter | SP | Free Agent | 21 | 06/28/2016 | New York | USA | Switch | Right | 6' 6" | 220 lbs | - |
| Suzuki, Takahiro | SS | Chicago Silver Sox | 27 | 12/13/2010 | Osaka | JPN | Left | Right | 6' 2" | 205 lbs | $280,000 |
| Sykes, Paul | 2B | Buckhead Bowties | 17 | 05/02/2020 | Coventry | ENG | Right | Right | 6' 2" | 180 lbs | - |
