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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sakei, Masahiro | SP | Phoenix Hotspur | 18 | 08/17/2007 | Futtsu | JPN | Switch | Right | 6' 6" | 200 lbs | - |
| Salas, Edgardo | SP | Chicago Gold Sox | 18 | 05/09/2007 | Santo Domingo | DOM | Right | Right | 6' 3" | 190 lbs | - |
| Samoyoa, Andrés | SP | Capital District Red Knights | 19 | 08/09/2006 | Valencia | VEN | Left | Left | 6' 0" | 175 lbs | - |
| Sánchez, Francisco | SP | New Amsterdam Republics | 17 | 03/27/2008 | Bonao | DOM | Switch | Right | 6' 2" | 175 lbs | - |
| Sánchez, José | SS | Chicago Hawks | 20 | 06/13/2005 | Cotuí | DOM | Right | Right | 6' 3" | 200 lbs | - |
| Sánchez, Juan | RP | Ft. Worth Cattlemen | 35 | 10/26/1990 | Santiago de Cuba | CUB | Left | Left | 6' 2" | 215 lbs | $1,400,000 |
| Sánchez, Juan | RP | New Amsterdam Republics | 24 | 09/09/2001 | Cumana | VEN | Right | Right | 5' 11" | 185 lbs | $280,000 |
| Sánchez, Rafael | RF | Phoenix Hotspur | 22 | 02/10/2003 | San Cristóbal | DOM | Left | Left | 6' 3" | 205 lbs | $280,000 |
| Sanders, Cory | SP | Phoenix Hotspur | 28 | 11/08/1997 | Estero | USA | Right | Right | 6' 5" | 235 lbs | $3,206,000 |
| Sanders, Steve | RP | Chicago Gold Sox | 28 | 12/27/1997 | Homosassa Springs | USA | Left | Right | 6' 2" | 195 lbs | $280,000 |
| Sandolva, Arturio | SP | Chicago Hawks | 20 | 09/03/2005 | Oruro | BOL | Switch | Right | 6' 2" | 180 lbs | - |
| Sandoval, Enrico | CF | Phoenix Hotspur | 17 | 12/08/2008 | Santiago | CHI | Left | Left | 6' 3" | 190 lbs | - |
| Sandoval, Javier | SS | Grafton Middies | 17 | 07/11/2008 | San Miguelito | PAN | Right | Right | 6' 1" | 175 lbs | - |
| Santos, Pedro | 2B | Grafton Middies | 26 | 07/27/1999 | Santo Domingo | DOM | Right | Right | 6' 3" | 215 lbs | $7,005,000 |
| Scarpenti, Washington | SP | Thunder Bay Northern Lions BC | 18 | 04/03/2007 | Artigas | URU | Left | Left | 6' 7" | 210 lbs | - |
| Schaefer, Chris | RP | Free Agent | 32 | 04/27/1993 | Dallas | USA | Right | Right | 6' 2" | 210 lbs | - |
| Schuler, Omar | 2B | New Amsterdam Republics | 23 | 09/09/2002 | Frankfurt | GER | Right | Right | 6' 3" | 200 lbs | $280,000 |
| Schultz, Jon | RP | Grafton Middies | 24 | 12/25/2001 | Brownsville | USA | Right | Right | 6' 5" | 215 lbs | $280,000 |
| Schuur, Victor | C | Detroit Renaissance | 18 | 08/07/2007 | Willemstad | CUR | Left | Right | 6' 0" | 190 lbs | - |
| Scott, Tyrone | 3B | Chicago Gold Sox | 32 | 07/09/1993 | Ft. Carson | USA | Right | Right | 6' 2" | 220 lbs | $13,000,000 |
| Segura, José | SS | Panama City Piranhas | 19 | 10/16/2006 | Maracaibo | VEN | Switch | Right | 6' 1" | 175 lbs | - |
| Shaffer, Cole | 1B | Wizarding Express | 28 | 07/14/1997 | New York | USA | Right | Right | 6' 0" | 210 lbs | $9,500,000 |
| Sheppard, Matt | 3B | Austin Rangers | 29 | 11/14/1996 | Vermillion | USA | Right | Right | 5' 9" | 185 lbs | $6,500,000 |
| Shibata, Arinori | RP | Free Agent | 32 | 11/05/1993 | Oyama | JPN | Right | Right | 6' 0" | 205 lbs | - |
| Shimizu, Yeijiro | SP | Chicago Gold Sox | 17 | 10/22/2008 | Yokohama | JPN | Right | Right | 6' 7" | 200 lbs | - |
| Silver, Mike | 1B | Detroit Renaissance | 36 | 04/14/1989 | Duluth | USA | Left | Right | 6' 1" | 210 lbs | $18,000,000 |
| Sima, Shih-k'ai | C | Brooklyn Dodgers | 19 | 09/22/2006 | Shantou | CHN | Right | Right | 6' 1" | 200 lbs | - |
| Smith, Michael | 1B | Wizarding Express | 30 | 06/22/1995 | Minneapolis | USA | Left | Left | 6' 5" | 255 lbs | $420,000 |
| Sosa, Félix | 3B | Phoenix Hotspur | 16 | 08/20/2009 | Bayaguana | DOM | Right | Right | 6' 0" | 175 lbs | - |
| Soto, Bartolo | CF | Grafton Middies | 16 | 09/07/2009 | Puerto Plata | DOM | Left | Left | 6' 2" | 175 lbs | - |
| Soto, Iván | SS | Austin Rangers | 16 | 07/17/2009 | Ciudad Guayana | VEN | Left | Right | 6' 2" | 175 lbs | - |
| Soto, Sixto | SP | Vancouver Grey Wolves | 19 | 08/31/2006 | Santiago | DOM | Right | Right | 5' 11" | 170 lbs | - |
| Souza, José | 3B | Phoenix Hotspur | 16 | 02/09/2009 | Tiquisate | GUA | Right | Right | 6' 1" | 180 lbs | - |
| Spitsbaard, Pieter | SP | Oakland Oaks | 17 | 08/10/2008 | Willemstad | CUR | Right | Right | 6' 0" | 175 lbs | - |
| Spivey, Asher | CL | Ft. Worth Cattlemen | 24 | 01/07/2001 | Dixmoor | USA | Left | Left | 6' 1" | 205 lbs | $280,000 |
| Stephenson, Gabe | SP | Wizarding Express | 25 | 03/04/2000 | Pleasant View | USA | Right | Right | 6' 3" | 205 lbs | $280,000 |
| Stewart, Carl | SP | Toledo Titans | 17 | 10/04/2008 | Mangilao | GUM | Switch | Right | 5' 10" | 160 lbs | - |
| Stone, Rob | RP | Free Agent | 28 | 04/17/1997 | Le Sueur | USA | Right | Right | 6' 2" | 215 lbs | - |
| Strickland, Philip | RF | Chicago Gold Sox | 24 | 04/05/2001 | Queens | USA | Left | Left | 5' 10" | 200 lbs | $280,000 |
| Suárez, Alfredo | CF | New Amsterdam Republics | 23 | 05/27/2002 | Managua | NCA | Right | Right | 6' 2" | 180 lbs | $280,000 |
| Sullivan, Lester | SP | Austin Rangers | 28 | 01/21/1997 | North Richland Hills | USA | Right | Right | 6' 0" | 195 lbs | $448,000 |
| Sun, Decheng | RP | Austin Rangers | 31 | 09/25/1994 | Taichung | TPE | Right | Right | 6' 1" | 215 lbs | $4,600,000 |
| Sutton, Cale | CF | Phoenix Hotspur | 31 | 11/29/1994 | Parole | USA | Right | Left | 6' 0" | 200 lbs | $21,000,000 |
| Sutton, Joe | SS | New Amsterdam Republics | 26 | 09/25/1999 | Benicia | USA | Left | Right | 6' 2" | 200 lbs | $280,000 |
| Swain, Bobby | SP | New Amsterdam Republics | 26 | 12/28/1999 | Socastee | USA | Right | Right | 6' 0" | 190 lbs | $3,744,000 |
