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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sáenz, Emílio | RF | New Amsterdam Republics | 32 | 11/24/1992 | Baltimore | USA | Left | Left | 5' 10" | 200 lbs | $2,700,000 |
| Saginov, Justin | C | D.C. Divided | 27 | 11/29/1997 | Portland | USA | Right | Right | 6' 4" | 230 lbs | $280,000 |
| Sai, Morihiro | SP | Grafton Middies | 20 | 12/20/2004 | Yokohama | JPN | Switch | Right | 5' 11" | 165 lbs | - |
| Saldaña, Júlio | RP | Oakland Oaks | 23 | 04/24/2001 | Santiago | DOM | Right | Right | 6' 7" | 210 lbs | $280,000 |
| Samoyoa, Andrés | SP | Capital District Red Knights | 18 | 08/09/2006 | Valencia | VEN | Left | Left | 6' 0" | 170 lbs | - |
| Sánchez, José | SS | Chicago Hawks | 19 | 06/13/2005 | Cotuí | DOM | Right | Right | 6' 3" | 195 lbs | - |
| Sánchez, Juan | SP | New Amsterdam Republics | 23 | 09/09/2001 | Cumana | VEN | Right | Right | 5' 11" | 180 lbs | $280,000 |
| Sánchez, Lorenzo | SP | Detroit Renaissance | 25 | 01/11/1999 | Puerto la Cruz | VEN | Left | Left | 6' 0" | 180 lbs | $2,400,000 |
| Sanders, Cory | RP | Phoenix Hotspur | 27 | 11/08/1997 | Estero | USA | Right | Right | 6' 5" | 230 lbs | $480,000 |
| Sandolva, Arturio | SP | Chicago Hawks | 19 | 09/03/2005 | Oruro | BOL | Switch | Right | 6' 2" | 180 lbs | - |
| Sandoval, Javier | SS | Grafton Middies | 16 | 07/11/2008 | San Miguelito | PAN | Right | Right | 6' 1" | 170 lbs | - |
| Santiago, Félix | RP | Toledo Titans | 18 | 02/02/2006 | La Romana | DOM | Right | Right | 6' 2" | 185 lbs | - |
| Santos, Eduardo | 3B | Grafton Middies | 20 | 11/16/2004 | Santo Domingo | DOM | Right | Right | 5' 10" | 175 lbs | - |
| Santos, Pedro | 2B | Grafton Middies | 25 | 07/27/1999 | Santo Domingo | DOM | Right | Right | 6' 3" | 215 lbs | $4,400,000 |
| Scarpenti, Washington | SP | Thunder Bay Northern Lions BC | 17 | 04/03/2007 | Artigas | URU | Left | Left | 6' 7" | 200 lbs | - |
| Schuler, Omar | 2B | New Amsterdam Republics | 22 | 09/09/2002 | Frankfurt | GER | Right | Right | 6' 3" | 190 lbs | $280,000 |
| Schultz, Jon | RP | Grafton Middies | 23 | 12/25/2001 | Brownsville | USA | Right | Right | 6' 5" | 215 lbs | $280,000 |
| Schuur, Victor | C | Detroit Renaissance | 17 | 08/07/2007 | Willemstad | CUR | Left | Right | 6' 0" | 185 lbs | - |
| Sears, Ray | 3B | D.C. Divided | 33 | 04/08/1991 | Pharr | USA | Left | Right | 5' 11" | 200 lbs | $11,590,000 |
| Segura, José | SS | Panama City Piranhas | 18 | 10/16/2006 | Maracaibo | VEN | Switch | Right | 6' 1" | 175 lbs | - |
| Silver, Mike | 1B | Detroit Renaissance | 35 | 04/14/1989 | Duluth | USA | Left | Right | 6' 1" | 205 lbs | $18,000,000 |
| Sima, Shih-k'ai | C | Brooklyn Dodgers | 18 | 09/22/2006 | Shantou | CHN | Right | Right | 6' 1" | 200 lbs | - |
| Simmons, Mark | RP | Oakland Oaks | 29 | 07/18/1995 | Grand Island | USA | Right | Right | 6' 1" | 205 lbs | $5,000,000 |
| Simpson, Henry | RP | Oakland Oaks | 28 | 08/14/1996 | Detroit | USA | Switch | Left | 6' 3" | 230 lbs | $470,000 |
| Smith, Adrian | C | Thunder Bay Northern Lions BC | 26 | 03/21/1998 | Alexandria | USA | Right | Right | 5' 11" | 215 lbs | $430,000 |
| Smith, David | DH | Thunder Bay Northern Lions BC | 26 | 06/29/1998 | Hayward | USA | Left | Right | 6' 0" | 185 lbs | $12,440,000 |
| Son, Dam | 1B | Brooklyn Dodgers | 17 | 11/07/2007 | Seoul | KOR | Right | Right | 6' 3" | 210 lbs | - |
| Soto, Sixto | SP | Vancouver Grey Wolves | 18 | 08/31/2006 | Santiago | DOM | Right | Right | 5' 10" | 165 lbs | - |
| Spiers, Reg | SS | Detroit Renaissance | 18 | 07/02/2006 | Unknown | AUS | Right | Right | 6' 2" | 170 lbs | - |
| Stark, Ed | SP | Toledo Titans | 25 | 09/14/1999 | Madera | USA | Right | Right | 6' 1" | 195 lbs | $280,000 |
| Stewart, Austin | SP | Louisville BC | 26 | 01/13/1998 | Queens | USA | Right | Right | 6' 0" | 185 lbs | $430,000 |
| Stone, Rob | SP | New Amsterdam Republics | 27 | 04/17/1997 | Le Sueur | USA | Right | Right | 6' 2" | 215 lbs | $450,000 |
| Stone, Ron | SP | Louisville BC | 24 | 07/19/2000 | Mission Viejo | USA | Right | Right | 6' 3" | 215 lbs | $280,000 |
| Suárez, Alfredo | CF | New Amsterdam Republics | 22 | 05/27/2002 | Managua | NCA | Right | Right | 6' 2" | 180 lbs | $280,000 |
| Swain, Bobby | SP | New Amsterdam Republics | 25 | 12/28/1999 | Socastee | USA | Right | Right | 6' 0" | 190 lbs | $3,744,000 |
| Szilard, Leo | SS | Vancouver Grey Wolves | 18 | 01/11/2006 | Doboz | HUN | Switch | Right | 6' 2" | 170 lbs | - |
