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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sai, Morihiro | SP | Grafton Middies | 19 | 12/20/2004 | Yokohama | JPN | Switch | Right | 5' 11" | 165 lbs | - |
| Salazar, José | C | Las Vegas Flamingos | 19 | 05/24/2004 | Caracas | VEN | Right | Right | 6' 7" | 220 lbs | - |
| Salazar, Ramiro | CF | Northern Virginia Retrievers | 29 | 09/10/1994 | Memphis | USA | Switch | Right | 6' 0" | 190 lbs | $20,830,000 |
| Salazar, Roberto | RF | Northern Virginia Retrievers | 24 | 08/01/1999 | Pizarrete | DOM | Left | Left | 6' 2" | 190 lbs | $9,840,000 |
| Saldaña, Júlio | SP | Oakland Oaks | 22 | 04/24/2001 | Santiago | DOM | Right | Right | 6' 7" | 210 lbs | $280,000 |
| Salgado, Jorge | CF | Ft. Worth Cattlemen | 20 | 12/29/2003 | Ibagué | COL | Right | Right | 6' 1" | 180 lbs | - |
| Salinas, José | RP | Thunder Bay Northern Lions BC | 27 | 12/30/1996 | San Jose | USA | Right | Right | 6' 7" | 250 lbs | $280,000 |
| Samoyoa, Andrés | SP | Capital District Red Knights | 17 | 08/09/2006 | Valencia | VEN | Left | Left | 6' 0" | 170 lbs | - |
| Samson, Addie | SP | Brooklyn Dodgers | 23 | 03/01/2000 | Westerveld | NED | Left | Left | 6' 1" | 195 lbs | $470,000 |
| Sánchez, David | SS | Panama City Piranhas | 24 | 11/30/1999 | Santo Domingo | DOM | Right | Right | 6' 2" | 200 lbs | $280,000 |
| Sánchez, Francisco | LF | Panama City Piranhas | 27 | 07/09/1996 | Río Grande | PUR | Left | Left | 6' 0" | 195 lbs | $5,700,000 |
| Sánchez, José | SS | Chicago Hawks | 18 | 06/13/2005 | Cotuí | DOM | Right | Right | 6' 3" | 190 lbs | - |
| Sanders, Cory | RP | Phoenix Hotspur | 26 | 11/08/1997 | Estero | USA | Right | Right | 6' 5" | 230 lbs | $430,000 |
| Sandolva, Arturio | SP | Chicago Hawks | 18 | 09/03/2005 | Oruro | BOL | Switch | Right | 6' 2" | 180 lbs | - |
| Santiago, Félix | SP | Toledo Titans | 17 | 02/02/2006 | La Romana | DOM | Right | Right | 6' 2" | 180 lbs | - |
| Santiago, José | SP | Phoenix Hotspur | 19 | 06/10/2004 | Jarabacoa | DOM | Left | Left | 6' 2" | 180 lbs | - |
| Santos, Eduardo | 3B | Grafton Middies | 19 | 11/16/2004 | Santo Domingo | DOM | Right | Right | 5' 10" | 175 lbs | - |
| Santos, Pedro | 2B | Grafton Middies | 24 | 07/27/1999 | Santo Domingo | DOM | Right | Right | 6' 3" | 205 lbs | $280,000 |
| Sanu, Takeru | LF | Free Agent | 35 | 03/06/1988 | Utsunomiya | JPN | Right | Right | 6' 0" | 195 lbs | - |
| Sassetti, Noël | SS | Austin Rangers | 20 | 07/30/2003 | Padova | ITA | Right | Right | 6' 2" | 175 lbs | - |
| Segura, José | SS | Panama City Piranhas | 17 | 10/16/2006 | Maracaibo | VEN | Switch | Right | 6' 1" | 175 lbs | - |
| Shelton, Ronald | 2B | Free Agent | 33 | 05/20/1990 | Windham | USA | Right | Right | 5' 10" | 190 lbs | - |
| Simmons, Mark | RP | Oakland Oaks | 28 | 07/18/1995 | Grand Island | USA | Right | Right | 6' 1" | 205 lbs | $5,000,000 |
| Smith, Adrian | C | Thunder Bay Northern Lions BC | 25 | 03/21/1998 | Alexandria | USA | Right | Right | 5' 11" | 210 lbs | $280,000 |
| Smith, Chris | 1B | Chicago Hawks | 35 | 05/02/1988 | Little Elm | USA | Right | Right | 6' 1" | 255 lbs | $11,000,000 |
| Smith, David | CF | Thunder Bay Northern Lions BC | 25 | 06/29/1998 | Hayward | USA | Left | Right | 6' 0" | 180 lbs | $12,440,000 |
| Sosa, Arturo | SS | Athletic Club KC | 19 | 02/11/2004 | Santo Domingo | DOM | Left | Right | 6' 1" | 185 lbs | - |
| Sotelo, Bru | SP | Rocky Mountain Nuggets | 18 | 11/21/2005 | Santiago | DOM | Switch | Right | 5' 10" | 160 lbs | - |
| Soto, Sixto | SP | Vancouver Grey Wolves | 17 | 08/31/2006 | Santiago | DOM | Right | Right | 5' 10" | 165 lbs | - |
| Spiers, Reg | SS | Detroit Renaissance | 17 | 07/02/2006 | Unknown | AUS | Right | Right | 6' 2" | 170 lbs | - |
| Stone, Rob | SP | New Amsterdam Republics | 26 | 04/17/1997 | Le Sueur | USA | Right | Right | 6' 2" | 215 lbs | $280,000 |
| Stoops, Gijs | SP | Philadelphia 1776 BC | 23 | 09/29/2000 | Nort Salinja | ANT | Right | Right | 6' 4" | 200 lbs | - |
| Strawson, Allan | SP | Free Agent | 27 | 07/30/1996 | Green Valley | USA | Left | Left | 6' 3" | 205 lbs | - |
| Suárez, Galtero | C | Houston 1837 BBC | 17 | 04/02/2006 | Santo Domingo | DOM | Switch | Right | 6' 0" | 180 lbs | - |
| Sun, Decheng | RP | Free Agent | 29 | 09/25/1994 | Taichung | TPE | Right | Right | 6' 1" | 210 lbs | - |
| Swain, Bobby | SP | New Amsterdam Republics | 24 | 12/28/1999 | Socastee | USA | Right | Right | 6' 0" | 190 lbs | $3,097,500 |
| Sykes, Richard | SP | Panama City Piranhas | 31 | 11/15/1992 | Milwaukee | USA | Right | Right | 6' 3" | 235 lbs | $1,700,000 |
| Szilard, Leo | SS | Vancouver Grey Wolves | 17 | 01/11/2006 | Doboz | HUN | Switch | Right | 6' 2" | 170 lbs | - |
