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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saginov, Justin | C | D.C. Divided | 24 | 11/29/1997 | Portland | USA | Right | Right | 6' 4" | 220 lbs | $280,000 |
| Saikawa, Toshiro | RP | Houston 1837 Colt .45s | 27 | 06/29/1994 | Hiroshima | JPN | Left | Right | 5' 8" | 185 lbs | $10,500,000 |
| Salaedo, Pancho | 2B | Montana Pandas | 22 | 12/19/1999 | Santo Domingo | DOM | Right | Right | 6' 3" | 185 lbs | $448,000 |
| Salazar, Jesús | SP | D.C. Divided | 17 | 10/09/2004 | Santo Domingo | DOM | Left | Left | 6' 1" | 175 lbs | - |
| Salazar, Mario | SS | Oakland Oaks | 16 | 05/23/2005 | Barahona | DOM | Right | Right | 6' 0" | 165 lbs | - |
| Salinas, Carlos | C | Hartford Whalers | 18 | 09/01/2003 | San Juan de Colón | VEN | Switch | Right | 6' 3" | 205 lbs | - |
| Sánchez, António | CF | Austin Rangers | 22 | 02/17/1999 | Ramón Santana | DOM | Right | Right | 6' 4" | 200 lbs | $280,000 |
| Sánchez, Carlos | SP | Philadelphia 1776 BC | 20 | 06/04/2001 | Maracaibo | VEN | Left | Left | 6' 2" | 180 lbs | $280,000 |
| Sánchez, Francisco | LF | Panama City Piranhas | 25 | 07/09/1996 | Río Grande | PUR | Left | Left | 6' 0" | 195 lbs | $4,000,000 |
| Sánchez, León | SS | Hartford Whalers | 18 | 04/16/2003 | San Miguelito | PAN | Right | Right | 6' 1" | 170 lbs | - |
| Sánchez, Lorenzo | SP | Hartford Whalers | 22 | 01/11/1999 | Puerto la Cruz | VEN | Left | Left | 6' 0" | 180 lbs | $280,000 |
| Sánchez, Rafael | SS | Vancouver Grey Wolves | 19 | 07/29/2002 | Barinas | VEN | Right | Right | 6' 0" | 175 lbs | - |
| Sandoval, Francisco | SP | Montana Pandas | 16 | 01/15/2005 | Jalapa | GUA | Right | Right | 6' 1" | 170 lbs | - |
| Sandoval, Ismael | SS | Austin Rangers | 16 | 03/24/2005 | Licey al Medio | DOM | Right | Right | 6' 0" | 170 lbs | - |
| Sandoval, Rodrigo | SP | Hartford Whalers | 18 | 02/18/2003 | San Pedro de Macorís | DOM | Right | Right | 6' 4" | 185 lbs | - |
| Santos, Francisco | SS | Vancouver Grey Wolves | 19 | 06/03/2002 | Guadalupe | COL | Left | Right | 6' 1" | 175 lbs | - |
| Santos, Luis | SP | Chicago Hawks | 18 | 04/01/2003 | Barquisimeto | VEN | Right | Right | 6' 4" | 185 lbs | - |
| Santos, Nathan | CF | Free Agent | 33 | 08/12/1988 | Manhattan | USA | Left | Left | 6' 1" | 200 lbs | - |
| Sasaki, Yoshiyuki | 1B | D.C. Divided | 32 | 09/30/1989 | Taketa | JPN | Right | Right | 5' 10" | 215 lbs | $490,000 |
| Sato, Reijiro | C | Thunder Bay Northern Lions BC | 29 | 06/15/1992 | Yamatotakada | JPN | Left | Right | 5' 11" | 210 lbs | $280,000 |
| Savage, Will | SP | Free Agent | 33 | 09/10/1988 | Florida Ridge | USA | Left | Left | 6' 0" | 210 lbs | - |
| Savary, Wilfrid | RF | Kingston Township Legion | 36 | 04/18/1985 | Hamilton | CAN | Left | Left | 6' 5" | 235 lbs | $756,000 |
| Scacceri, Poto | SP | Oakland Oaks | 17 | 09/13/2004 | Caraballeda | VEN | Right | Right | 5' 11" | 170 lbs | - |
| Schaefer, Chris | RP | Seattle Aviators | 28 | 04/27/1993 | Dallas | USA | Right | Right | 6' 2" | 200 lbs | $700,000 |
| Schneider, Bill | RP | Seattle Aviators | 30 | 07/10/1991 | Arlington | USA | Switch | Right | 5' 11" | 195 lbs | $4,520,000 |
| Schneider, Ray | LF | Free Agent | 31 | 08/21/1990 | Grandville | USA | Left | Right | 6' 3" | 220 lbs | - |
| Shaffer, Cole | 2B | Wizarding Express | 24 | 07/14/1997 | New York | USA | Right | Right | 6' 0" | 190 lbs | $4,000,000 |
| Sheppard, Willem | RF | Montana Pandas | 16 | 09/19/2005 | Taupo | NZL | Left | Left | 6' 0" | 175 lbs | - |
| Silva, Juan | RF | Houston 1837 Colt .45s | 17 | 04/29/2004 | Altamira | DOM | Left | Left | 5' 11" | 175 lbs | - |
| Silva, Luis | C | Oakland Oaks | 26 | 01/25/1995 | San Diego | USA | Right | Right | 6' 2" | 245 lbs | $280,000 |
| Simpson, Ryan | RF | Free Agent | 27 | 11/11/1994 | Albuquerque | USA | Right | Right | 5' 8" | 180 lbs | - |
| Smith, Ben | SP | Free Agent | 29 | 06/03/1992 | Albany | USA | Right | Right | 5' 10" | 205 lbs | - |
| Smith, David | CF | Thunder Bay Northern Lions BC | 23 | 06/29/1998 | Hayward | USA | Left | Right | 6' 0" | 170 lbs | $8,440,000 |
| Smith, Joe | C | Philadelphia 1776 BC | 24 | 07/25/1997 | New York | USA | Right | Right | 5' 11" | 195 lbs | $280,000 |
| Solano, Javier | C | Houston 1837 Colt .45s | 18 | 03/18/2003 | Cabimas | VEN | Right | Right | 6' 3" | 205 lbs | - |
| Solís, Jaime | 2B | Capital District Red Knights | 17 | 01/08/2004 | Ocumare del Tuy | VEN | Right | Right | 6' 0" | 170 lbs | - |
| Solíz, Tony | SP | Thunder Bay Northern Lions BC | 17 | 01/12/2004 | Papantla | MEX | Right | Right | 6' 2" | 180 lbs | - |
| Soriano, Carlos | SP | Seattle Aviators | 18 | 09/25/2003 | Santiago | DOM | Right | Right | 6' 2" | 175 lbs | - |
| Soto, Carlos | 2B | Seattle Aviators | 17 | 04/08/2004 | Catia La Mar | VEN | Right | Right | 6' 0" | 170 lbs | - |
| Steele, Chuck | SP | Free Agent | 26 | 08/09/1995 | Independence | USA | Left | Right | 6' 2" | 215 lbs | - |
| Stevens, Dale | RP | Hartford Whalers | 27 | 11/20/1994 | Anna | USA | Left | Left | 6' 3" | 210 lbs | $280,000 |
| Stewart, Bob | RP | Montana Pandas | 25 | 02/04/1996 | Port Orange | USA | Right | Left | 6' 4" | 210 lbs | $280,000 |
| Sullivan, Woody | SP | Philadelphia 1776 BC | 24 | 09/02/1997 | Plymouth Township | USA | Left | Left | 6' 1" | 205 lbs | $280,000 |
| Sykes, Richard | SP | Panama City Piranhas | 29 | 11/15/1992 | Milwaukee | USA | Right | Right | 6' 3" | 235 lbs | $1,700,000 |
