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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sáenz, Emílio | RF | Orlando City | 24 | 11/24/1992 | Baltimore | USA | Left | Left | 5' 10" | 195 lbs | $8,562,500 |
| Sakamoto, Toshitsugu | LF | Lone Star BC | 28 | 02/20/1989 | Kumamoto | JPN | Right | Right | 6' 4" | 230 lbs | $6,295,000 |
| Salazar, Roberto | CF | Northern Virginia Retrievers | 18 | 08/01/1999 | Pizarrete | DOM | Left | Left | 6' 2" | 185 lbs | - |
| Salinas, Juan | CF | New Amsterdam Republics | 18 | 09/11/1999 | San Antonio Buenavista | MEX | Right | Right | 6' 0" | 180 lbs | - |
| Sánchez, Manuel | SP | Philadephia 1776 BC | 17 | 01/04/2000 | Catia La Mar | VEN | Left | Left | 6' 7" | 195 lbs | - |
| Sánchez, Orlando | SP | Northern Virginia Retrievers | 19 | 08/19/1998 | Santo Domingo | DOM | Left | Left | 6' 2" | 185 lbs | - |
| Savage, Will | MR | Northern Virginia Retrievers | 29 | 09/10/1988 | Florida Ridge | USA | Left | Left | 6' 0" | 205 lbs | $1,610,000 |
| Scott, Chip | MR | Orlando City | 24 | 12/29/1992 | Indian Springs Village | USA | Right | Right | 6' 2" | 210 lbs | $280,000 |
| Serna, José | 2B | Montreal Rivermen | 16 | 12/02/2000 | Santiago | DOM | Left | Right | 6' 1" | 185 lbs | - |
| Servergnini, Matthieu | 2B | Philadephia 1776 BC | 37 | 07/31/1980 | Santa Teresa | VEN | Switch | Right | 5' 10" | 195 lbs | $1,180,000 |
| Shaffer, Roger | LF | Northern Virginia Retrievers | 31 | 01/03/1986 | St. Louis | USA | Left | Left | 6' 2" | 210 lbs | $3,410,000 |
| Shaw, Joe | SS | Buckhead Bowties | 27 | 10/26/1989 | North Babylon | USA | Right | Right | 6' 3" | 205 lbs | $400,000 |
| Shelton, Ronald | SS | New Amsterdam Republics | 27 | 05/20/1990 | Windham | USA | Right | Right | 5' 10" | 190 lbs | $2,125,000 |
| Silva, Héctor | SP | Montreal Rivermen | 16 | 01/20/2001 | Charallave | VEN | Left | Right | 6' 1" | 165 lbs | - |
| Simmons, Forest | CF | Orlando City | 29 | 10/30/1987 | Oakland | USA | Right | Left | 5' 11" | 200 lbs | $5,680,000 |
| Smith, Chris | 1B | Atlanta Smoke | 29 | 05/02/1988 | Little Elm | USA | Right | Right | 6' 1" | 240 lbs | $400,000 |
| Smith, Tom | SS | Lone Star BC | 27 | 09/11/1990 | Moline | USA | Left | Left | 6' 3" | 240 lbs | $280,000 |
| Solano, Pablo | CL | New Amsterdam Republics | 28 | 05/12/1989 | San Juan de la Maguana | DOM | Right | Right | 6' 0" | 205 lbs | $800,000 |
| Solís, Fernando | SP | Rocky Mountain Nuggets | 17 | 11/16/1999 | Barahona | DOM | Right | Right | 6' 8" | 210 lbs | - |
| Soto, Alfonso | 3B | Orlando City | 39 | 10/20/1977 | Barcelona | VEN | Right | Right | 6' 0" | 220 lbs | $950,000 |
| Souza, Ramón | LF | Orlando City | 24 | 08/26/1993 | Craigsville | USA | Right | Right | 6' 0" | 195 lbs | $280,000 |
| Stanley, Donald | 2B | Northern Virginia Retrievers | 22 | 01/30/1995 | Macomb Township | USA | Right | Right | 6' 0" | 190 lbs | $2,400,000 |
| Staton, Cory | CF | Orlando City | 30 | 09/05/1987 | Newark | USA | Right | Right | 6' 0" | 205 lbs | $2,500,000 |
| Stewart, Craig | RF | Chicago Gold Sox | 27 | 03/05/1990 | West Valley City | USA | Right | Right | 6' 0" | 190 lbs | $7,600,000 |
| Stoops, Gijs | SP | Philadephia 1776 BC | 17 | 09/29/2000 | Nort Salinja | ANT | Right | Right | 6' 3" | 180 lbs | - |
| Sutton, Cale | CF | Columbus Tidal Waves | 22 | 11/29/1994 | Parole | USA | Right | Left | 6' 0" | 200 lbs | $4,830,000 |
