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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sabastro, Lorenzo | CF | Buckhead Bowties | 16 | 01/13/2000 | Fusagasuga | COL | Right | Right | 6' 1" | 175 lbs | - |
| Salas, Leonardo | SP | Phoenix Hotspur | 17 | 06/05/1999 | Caraballeda | VEN | Right | Right | 5' 11" | 165 lbs | - |
| Saldaña, Jorge | SS | Atlanta Smoke | 16 | 06/03/2000 | Monte Plata | DOM | Right | Right | 6' 1" | 170 lbs | - |
| Sánchez, Ernesto | LF | Lexington BC | 17 | 01/21/1999 | Montellano | DOM | Left | Left | 6' 1" | 175 lbs | - |
| Sánchez, José | C | Phoenix Hotspur | 16 | 11/19/1999 | Santo Domingo | DOM | Right | Right | 6' 2" | 200 lbs | - |
| Sánchez, Leonardo | 1B | Lexington BC | 33 | 09/02/1983 | Cabudare | VEN | Right | Right | 6' 2" | 230 lbs | $650,000 |
| Sánchez, Orlando | 1B | Louisville Slugs | 17 | 09/04/1999 | Monte Cristi | DOM | Right | Left | 6' 2" | 200 lbs | - |
| Santos, Albert | SS | Louisville Slugs | 16 | 12/05/1999 | Filas de Mariche | VEN | Switch | Right | 6' 2" | 180 lbs | - |
| Santos, Pedro | 2B | Grafton Middies | 17 | 07/27/1999 | Santo Domingo | DOM | Right | Right | 6' 3" | 190 lbs | - |
| Sato, Suezo | MR | Brooklyn Dodgers | 27 | 04/09/1989 | Tajimi | JPN | Right | Right | 6' 0" | 205 lbs | $400,000 |
| Schneider, Tony | MR | California Oceanliners | 29 | 03/04/1987 | Charlotte | USA | Left | Left | 5' 10" | 190 lbs | $750,000 |
| Schroeder, Ray | C | Phoenix Hotspur | 26 | 11/21/1989 | Churchill | USA | Right | Right | 6' 2" | 250 lbs | $1,500,000 |
| Scott, Tyrone | SS | Real Hartford CB Whalers | 23 | 07/09/1993 | Ft. Carson | USA | Right | Right | 6' 2" | 190 lbs | $400,000 |
| Sears, Ray | 3B | Brooklyn Dodgers | 25 | 04/08/1991 | Pharr | USA | Left | Right | 5' 11" | 200 lbs | $7,000,000 |
| Senna, Aurélio | SP | Rocky Mountain Nuggets | 31 | 02/10/1985 | San Cristóbal | VEN | Right | Right | 6' 3" | 220 lbs | $1,000,000 |
| Serna, Raúl | SP | Real Hartford CB Whalers | 18 | 07/30/1998 | Santo Domingo | DOM | Right | Right | 6' 3" | 190 lbs | - |
| Shaw, Gerald | 2B | Free Agent | 42 | 02/12/1974 | Kernersville | USA | Right | Right | 5' 11" | 205 lbs | - |
| Shelby, Robert | 3B | Real Hartford CB Whalers | 35 | 08/27/1981 | New York | USA | Switch | Right | 5' 11" | 210 lbs | $19,000,000 |
| Silva, Jorge | SP | Buckhead Bowties | 19 | 03/25/1997 | Valencia | VEN | Right | Right | 6' 2" | 185 lbs | - |
| Silva, Manuel | SP | Lexington BC | 18 | 12/15/1997 | Moca | DOM | Right | Right | 6' 2" | 180 lbs | - |
| Silver, Mike | 1B | Louisville Slugs | 27 | 04/14/1989 | Duluth | USA | Left | Right | 6' 1" | 210 lbs | $15,000,000 |
| Simmons, Nick | RF | Detroit Reapers | 26 | 03/15/1990 | River Ridge | USA | Right | Left | 6' 0" | 200 lbs | $8,000,000 |
| Smith, Paul | 3B | Boston Patriots | 25 | 11/18/1990 | Waterbury | USA | Left | Right | 5' 11" | 210 lbs | $660,000 |
| Snow, Myron | MR | Lexington BC | 30 | 07/15/1986 | North Weeki Wachee | USA | Right | Right | 6' 0" | 205 lbs | $4,430,000 |
| Snyder, Carl | MR | Rocky Mountain Nuggets | 27 | 07/07/1989 | Los Angeles | USA | Right | Right | 6' 0" | 200 lbs | $400,000 |
| Soto, Miguel | CF | Free Agent | 30 | 07/28/1986 | Havana | CUB | Switch | Right | 6' 0" | 200 lbs | - |
| Spear, Keith | LF | Detroit Reapers | 26 | 07/19/1990 | Abbeville | USA | Left | Left | 5' 11" | 200 lbs | $2,000,000 |
| Spivey, Cliff | MR | Free Agent | 24 | 07/03/1992 | Columbia | USA | Right | Right | 5' 11" | 190 lbs | - |
| Suzuki, Eiji | 2B | Brooklyn Dodgers | 30 | 12/03/1985 | Fukuoka | JPN | Switch | Right | 6' 0" | 195 lbs | $12,250,000 |
| Sykes, Richard | MR | Phoenix Hotspur | 23 | 11/15/1992 | Milwaukee | USA | Right | Right | 6' 3" | 210 lbs | $650,000 |
