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| Saturday, November 27th, 2021 |
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| Springfield Simpsons: Signed Pitching Coach Albert Benavidez to a 3-year contract extension. |
| Tuesday, November 23rd, 2021 |
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| Springfield Simpsons: Signed Hitting Coach Alex Fuller to a 1-year contract extension. |
| Friday, November 5th, 2021 |
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| Newark Bulldogs: Signed pitching coach Norris Reid. |
| Lima Oilers: Signed hitting coach Raúl Martínez. |
| Thursday, November 4th, 2021 |
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| Newark Bulldogs: Signed hitting coach Jesús Saucedo. |
| Tuesday, October 19th, 2021 |
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| Reading Rainbows: Released MR Bryan DeWitt. |
| Wilmington Rebels: Released CF Shawn Griffin. |
| Wilmington Rebels: Released LF Carl Nicholson. |
| Buffalo LightSabres: Released SP José Gonzáles. |
| Buffalo LightSabres: Released C Carlos Zúńiga. |
| Lima Oilers: Hitting Coach Jesús Saucedo leaves the team, his contract was not renewed. |
| Newark Bulldogs: Pitching Coach José Valéncia leaves the team, his contract was not renewed. |
| Newark Bulldogs: Hitting Coach Werner Smiley leaves the team, his contract was not renewed. |
| Buffalo LightSabres: Manager Chip Justice leaves the team, his contract was not renewed. |
| Buffalo LightSabres: Hitting Coach Alejandro González leaves the team, his contract was not renewed. |
