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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
| Salas, Juan | RF | San Jose Missions | 33 | 06/27/1985 | Santa Clara | CUB | Right | Left | 6' 0" | 220 lbs | - |
| Salcido, Jorge | RF | Spokane Trappers | 29 | 05/21/1989 | Moore | USA | Switch | Right | 5' 11" | 197 lbs | $400,000 |
| Salgado, Vicente | 3B | Albuquerque Isotopes | 28 | 02/07/1990 | Las Cumbres | PAN | Right | Right | 6' 0" | 221 lbs | - |
| Sánchez, Manny | RF | Mexico City Cerveceros | 27 | 03/28/1991 | Rosario | ARG | Right | Right | 6' 1" | 208 lbs | - |
| Sánchez, Mario | RF | Calgary Cowboys | 24 | 11/08/1994 | Valencia | VEN | Right | Right | 6' 3" | 200 lbs | - |
| Sandoval, Jesús | 1B | Free Agent | 31 | 05/26/1987 | Cascade-Fairwood | USA | Right | Right | 6' 1" | 183 lbs | - |
| Sandry, James | 1B | Redwood City Redwoods | 27 | 02/08/1991 | Sint Nicolas | ARU | Right | Right | 5' 9" | 174 lbs | - |
| Sanford, Mike | LF | Vancouver Vipers | 28 | 04/12/1990 | Rainbow City | USA | Left | Left | 6' 0" | 192 lbs | - |
| Santana, Carlos | MR | Free Agent | 26 | 04/09/1992 | Cockeysville | USA | Left | Left | 5' 11" | 220 lbs | - |
| Santillanenz, Rafael | SP | Calgary Cowboys | 32 | 09/18/1986 | Topton | USA | Right | Right | 6' 1" | 190 lbs | - |
| Sayuki, Takechi | SP | Mexico City Cerveceros | 22 | 01/04/1996 | Atsugi | JPN | Right | Right | 6' 0" | 215 lbs | - |
| Schultz, Donald | LF | Calgary Cowboys | 30 | 01/12/1988 | Cottonwood-Verde Village | USA | Left | Left | 6' 5" | 181 lbs | - |
| Schultz, Greg | C | Vancouver Vipers | 25 | 07/15/1993 | Pinehurst | USA | Left | Right | 5' 11" | 190 lbs | - |
| Schute, Braydon | CL | Lansing Lugnuts | 22 | 12/13/1996 | Calgary | CAN | Left | Left | 5' 11" | 215 lbs | - |
| Sekiguchi, Kantaro | 3B | Mile High Broncos | 22 | 05/28/1996 | Kagoshima | JPN | Left | Right | 6' 0" | 215 lbs | - |
| Shelton, Eric | CF | San Jose Missions | 29 | 11/26/1989 | Estates of Fort Lauderdale | USA | Switch | Right | 6' 1" | 216 lbs | - |
| Smart, Ray | LF | Calgary Cowboys | 32 | 10/24/1986 | Tampa | USA | Right | Right | 6' 1" | 180 lbs | $400,000 |
| Smith, Arthur | MR | Free Agent | 34 | 05/27/1984 | Chicago | USA | Switch | Right | 6' 4" | 188 lbs | - |
| Smith, Dave | C | Las Vegas Stars | 32 | 05/22/1986 | Pflugerville | USA | Left | Right | 6' 1" | 178 lbs | - |
| Smith, John | SP | Lansing Lugnuts | 24 | 07/05/1994 | Hastings | USA | Right | Right | 6' 0" | 215 lbs | - |
| Smith, Scott | MR | Redwood City Redwoods | 29 | 05/28/1989 | Dodge City | USA | Left | Right | 6' 2" | 192 lbs | - |
| Snow, Dan | 3B | Redwood City Redwoods | 24 | 07/21/1994 | Winnipeg | CAN | Right | Right | 5' 8" | 180 lbs | - |
| Snow, Eugene | MR | Free Agent | 30 | 12/23/1988 | San Juan | PUR | Right | Right | 6' 2" | 198 lbs | - |
| Sosa, José | 2B | Albuquerque Isotopes | 29 | 01/10/1989 | Panama | PAN | Switch | Right | 6' 3" | 206 lbs | - |
| Soto, Ramón | MR | Mexico City Cerveceros | 27 | 02/16/1991 | Santo Domingo | DOM | Right | Right | 5' 11" | 205 lbs | - |
| Soto, Vicente | 1B | Redwood City Redwoods | 24 | 06/23/1994 | Huntington Beach | USA | Left | Left | 6' 0" | 230 lbs | - |
| Souza, Manuel | MR | Santa Monica Bruins | 30 | 05/01/1988 | Tegucigalpa | HON | Left | Left | 6' 6" | 221 lbs | - |
| Spies, Larry | 3B | Vancouver Vipers | 30 | 09/10/1988 | Manhattan | USA | Right | Right | 6' 1" | 203 lbs | - |
| Stagg, Randy | MR | Vancouver Vipers | 31 | 07/03/1987 | Montreal | CAN | Left | Left | 6' 1" | 199 lbs | - |
| Stevenson, John | 1B | Mexico City Cerveceros | 27 | 02/01/1991 | Goleta | USA | Left | Left | 6' 5" | 201 lbs | - |
| Stewart, Stan | CL | Vancouver Vipers | 26 | 08/29/1992 | Los Angeles | USA | Right | Right | 6' 3" | 200 lbs | - |
| Swanson, Keith | SP | Lansing Lugnuts | 23 | 02/08/1995 | Gadsden | USA | Left | Left | 6' 2" | 220 lbs | - |
