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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salas, Bernardo | RP | MSL Charleston Battery | 19 | 08/30/2037 | Ocotlan | MEX | Right | Right | 6' 8" | 205 lbs | - |
| Salmi, Mikko | SP | MSL Northern Virginia Rainbow Mermaids | 16 | 03/04/2040 | Erdokertes | HUN | Right | Right | 6' 5" | 185 lbs | - |
| Sameno, Jorge | 3B | MSL Echo Park Lakers | 18 | 05/23/2038 | Manzanillo | CUB | Right | Right | 6' 2" | 185 lbs | - |
| Sandoval, Miguel | RP | MSL Buckhead Bowties | 17 | 09/03/2039 | Zacatecas | MEX | Right | Right | 6' 2" | 175 lbs | - |
| Santa, Cássio | RP | MSL Dayton Dirty Reds | 16 | 01/27/2040 | Esperantina | BRA | Left | Left | 6' 4" | 185 lbs | - |
| Santos, Juan | 1B | MSL Toledo Stingers | 17 | 09/26/2039 | San José | CRC | Right | Right | 6' 0" | 195 lbs | - |
| Shan, Eng-hee | LF | MSL Northern Virginia Rainbow Mermaids | 19 | 10/29/2037 | Tucheng | TPE | Right | Right | 6' 6" | 205 lbs | - |
| Shelley, Dermott | 2B | MSL Buckhead Bowties | 19 | 12/30/2037 | Christiansted | VIR | Switch | Right | 6' 1" | 185 lbs | - |
| Sherman, Justin | RP | MSL Santa Catalina Condor | 19 | 09/07/2037 | Belize | BLZ | Left | Left | 6' 4" | 180 lbs | - |
| Silva, Edgardo | RP | MSL Nova Scotia Leviathan | 19 | 12/16/2037 | Santiago | DOM | Right | Right | 6' 2" | 185 lbs | - |
| Silva, Iván | RP | MSL Toledo Stingers | 18 | 01/09/2038 | La Fría | VEN | Right | Right | 6' 9" | 205 lbs | - |
| Silven, Manne | LF | MSL Echo Park Lakers | 17 | 04/08/2039 | Szob | HUN | Left | Left | 6' 3" | 180 lbs | - |
| Smith, Chris | LF | Free Agent | 19 | 01/03/2037 | New Haven | USA | Right | Right | 6' 2" | 170 lbs | - |
| Snel, Ferdie | 1B | Free Agent | 18 | 01/04/2038 | Tilburg | NED | Right | Right | 6' 2" | 200 lbs | - |
| Snijders, Walter | CF | MSL Santa Catalina Condor | 17 | 11/08/2039 | Parakai | NZL | Right | Left | 6' 0" | 160 lbs | - |
| Sol, Seung-nam | CF | MSL Dayton Dirty Reds | 18 | 06/29/2038 | Sinpo | PRK | Right | Right | 6' 2" | 170 lbs | - |
| Solís, Iván | C | MSL Colorado Billy Goats | 17 | 09/18/2039 | Toluca | MEX | Right | Right | 6' 4" | 200 lbs | - |
| Song, Min-ho | 2B | MSL Kingston Township Knights | 18 | 01/15/2038 | Ansan | KOR | Right | Right | 6' 2" | 175 lbs | - |
| Soto, Félix | CF | MSL Kingston Township Knights | 17 | 01/29/2039 | Managua | NCA | Right | Right | 6' 2" | 175 lbs | - |
| Steenbergen, Valke | SP | MSL Thunder Bay Northern Lions BC | 17 | 06/21/2039 | Willemstad | CUR | Right | Right | 6' 2" | 175 lbs | - |
| Sturm, Mitchell | SP | MSL Charleston Battery | 19 | 12/19/2037 | Princess Quarter | SIM | Right | Right | 6' 9" | 215 lbs | - |
| Sánchez, Lorenzo | RP | MSL Buckhead Bowties | 17 | 06/15/2039 | Anaco | VEN | Right | Right | 6' 0" | 165 lbs | - |
