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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, Jorge | CF | Jersey City Tritons | 26 | 06/13/2028 | Valencia | VEN | Left | Left | 6' 1" | 195 lbs | - |
| Samuels, George | SS | Port Royal Disaster | 33 | 10/28/2021 | Arnold | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sanders, Kevin | CF | Salt Lake City Buzz | 30 | 08/28/2024 | Union | USA | Right | Right | 6' 0" | 195 lbs | - |
| Santana, Júlio | RF | Pawnee ParksNRec | 25 | 05/29/2029 | Ponce | PUR | Left | Left | 6' 3" | 210 lbs | - |
| Santos, Jorge | RP | Vermont Lake Monsters | 27 | 06/23/2027 | San Miguel | CRC | Left | Left | 6' 3" | 200 lbs | - |
| Satiro, Gustavo | CF | Austin Black Mambas | 28 | 12/29/2026 | Rome | ITA | Right | Right | 6' 0" | 200 lbs | - |
| Sato, Kuniyuki | 3B | Austin Black Mambas | 29 | 10/13/2025 | Nishinomiya | JPN | Right | Right | 6' 2" | 200 lbs | - |
| Sato, Mochihito | SP | Salt Lake City Buzz | 30 | 04/16/2024 | Saitama | JPN | Right | Left | 6' 2" | 195 lbs | $280,000 |
| Schmitt, Damien | SP | Jersey City Tritons | 27 | 11/15/2027 | Civrieux-dAzergues | FRA | Right | Right | 6' 8" | 200 lbs | $280,000 |
| Seema, Shu-yaan | 3B | Port Royal Disaster | 33 | 11/13/2021 | Saigong | HKG | Right | Right | 6' 4" | 205 lbs | $280,000 |
| Sherman, Mike | 2B | Port Huron Blitzkrieg | 30 | 06/12/2024 | Colorado Springs | USA | Switch | Right | 6' 1" | 195 lbs | - |
| Shoemaker, Andrew | SP | Vermont Lake Monsters | 29 | 08/01/2025 | West Long Branch | USA | Right | Right | 6' 0" | 200 lbs | $280,000 |
| Silva, José | 3B | Ft. Myers Marlins | 28 | 06/12/2026 | Enriquillo | DOM | Left | Right | 6' 0" | 190 lbs | - |
| Sim, Pyeong-ho | 2B | Ft. Myers Marlins | 28 | 03/25/2026 | Seongnam | KOR | Switch | Right | 6' 4" | 200 lbs | - |
| Simha, Balanatha | 3B | Port Huron Blitzkrieg | 23 | 02/03/2031 | Pune Cantonment | IND | Right | Right | 6' 3" | 200 lbs | - |
| Simmons, Marcus | RF | Free Agent | 31 | 01/13/2023 | Rockford | USA | Left | Left | 6' 6" | 210 lbs | - |
| Sims, Nathan | RP | Jersey City Tritons | 29 | 10/05/2025 | Toledo | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sinke, Marnix | 3B | Ft. Myers Marlins | 26 | 05/20/2028 | Princess Quarter | SIM | Right | Right | 6' 2" | 205 lbs | - |
| Slaughter, Bill | SP | Free Agent | 34 | 05/27/2020 | Markham | USA | Right | Right | 5' 11" | 200 lbs | - |
| Smith, Artie | CF | Syracuse Squirrel Monkeys | 30 | 10/19/2024 | South San Jose Hills | USA | Left | Left | 6' 4" | 190 lbs | $280,000 |
| Smith, Jim | SS | Pawnee ParksNRec | 32 | 12/02/2022 | Queens | USA | Right | Right | 6' 0" | 200 lbs | - |
| Soto, Eduardo | RP | Pawnee ParksNRec | 24 | 02/10/2030 | Ecatepec | MEX | Left | Left | 6' 2" | 190 lbs | - |
| Sovaiala, Will | RP | Nashville Hot Chickens | 35 | 03/03/2019 | Rochester | USA | Right | Right | 6' 0" | 200 lbs | - |
| Spilsbury, Zachary | C | Port Huron Blitzkrieg | 27 | 07/27/2027 | London | ENG | Right | Right | 6' 1" | 200 lbs | - |
| Stevens, Claude | RP | Ft. Myers Marlins | 33 | 07/04/2021 | Kansas City | USA | Left | Right | 6' 7" | 205 lbs | - |
| Stevenson, Arthur | SP | Free Agent | 34 | 10/09/2020 | Richland Center | USA | Left | Left | 6' 4" | 200 lbs | - |
| Stevenson, Ron | CF | Austin Black Mambas | 31 | 12/08/2023 | Suwanee | USA | Left | Left | 6' 4" | 205 lbs | - |
| Stewart, Lane | SP | Austin Black Mambas | 30 | 07/06/2024 | Chandler | USA | Switch | Right | 6' 2" | 200 lbs | - |
| Stjerna, Ken | SS | Port Royal Disaster | 26 | 06/22/2028 | Ware | USA | Left | Right | 6' 0" | 200 lbs | $280,000 |
| Stokes, Curt | RP | Austin Black Mambas | 28 | 05/04/2026 | Middleton | USA | Left | Left | 6' 1" | 195 lbs | $280,000 |
| Sugimoto, Mitsuoki | SS | Syracuse Squirrel Monkeys | 31 | 05/07/2023 | Matsudo | JPN | Left | Right | 6' 4" | 200 lbs | - |
| Sáenz, Orlando | LF | Ft. Myers Marlins | 29 | 03/07/2025 | Santiago | DOM | Switch | Right | 5' 10" | 190 lbs | $1,100,000 |
| Sánchez, Cristo | SP | Port Huron Blitzkrieg | 29 | 09/08/2025 | Barva | CRC | Left | Left | 6' 1" | 190 lbs | - |
