 |
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| Friday, December 26th , 2053 |
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| MSL Nova Scotia Leviathan: LF Pedro Mejía was designated for assignment. |
| Sunday, December 14th , 2053 |
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| MSL Nova Scotia Leviathan: 1B Darryl Dawson was designated for assignment. |
| Wednesday, October 29th , 2053 |
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| MSL Northern Virginia Rainbow Mermaids: Signed Manager Leslie Brooks. |
| Monday, October 27th , 2053 |
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| MSL Detroit Elite: Signed Manager Juan Valéncia. |
| Saturday, October 25th , 2053 |
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| MSL Nova Scotia Leviathan: 3B Fabi Polykovsky retired from professional baseball. |
| MSL Santa Catalina Condor: Hitting Coach León González leaves the team, his contract was not renewed |
| MSL Charleston Battery: Signed Hitting Coach Greg Brode to a 2-year contract extension. |
| MSL Charleston Battery: Signed Pitching Coach Ángel Ruíz to a 2-year contract extension. |
| MSL D.C. Divided: Signed Manager Dave Lee to a 3-year contract extension. |
| MSL D.C. Divided: Signed Hitting Coach Sam Lee to a 2-year contract extension. |
| MSL D.C. Divided: Signed Pitching Coach Josh Parker to a 2-year contract extension. |
| MSL Detroit Elite: Manager Robert Dickinson leaves the team, his contract was not renewed |
| MSL Detroit Elite: Hitting Coach Thom Marshall leaves the team, his contract was not renewed |
| MSL Nova Scotia Leviathan: Pitching Coach Todd Porter leaves the team, his contract was not renewed |
| MSL Nova Scotia Leviathan: Hitting Coach Jon Frederick leaves the team, his contract was not renewed |
| MSL Northern Virginia Rainbow Mermaids: Hitting Coach Orlando Deleón leaves the team, his contract was not renewed |
| MSL Northern Virginia Rainbow Mermaids: Manager Jaime Torres leaves the team, his contract was not renewed |
| MSL Echo Park Lakers: Signed Manager Mike Carlisle to a 3-year contract extension. |
| Monday, September 29th , 2053 |
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| MSL Charleston Battery: Released RP Dmitr Znamenschikov. |
| Friday, September 26th , 2053 |
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| MSL Charleston Battery: Released RP Germán Chávez. |
| Saturday, September 6th , 2053 |
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| MSL D.C. Divided: Activated CF Iikka Pirinen from the injured list. |
| MSL St. Louis Coeur: Activated 2B Xing-fu Tian from the injured list. |
| MSL St. Louis Coeur: Activated SP Sebastian Mawle from the injured list. |
| MSL Charleston Battery: Released RP Júlio Guzmán. |
