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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sakei, Kazuhiko | 1B | MSL Baltimore Bullets | 17 | 06/26/2036 | Kofu | JPN | Left | Left | 6' 4" | 200 lbs | - |
| Salazar, José | RP | MSL Toledo Stingers | 17 | 06/02/2036 | Santo Domingo | DOM | Switch | Right | 5' 11" | 160 lbs | - |
| Salazar, Octávio | 2B | MSL Colorado Billy Goats | 19 | 11/23/2034 | Belize | BLZ | Left | Right | 6' 4" | 200 lbs | - |
| Sam, Jong-min | SP | MSL Colorado Billy Goats | 17 | 07/18/2036 | Changwon | KOR | Right | Right | 6' 0" | 170 lbs | - |
| Sandoval, Carlos | SP | MSL Long Island Lighthouse | 18 | 10/09/2035 | Santo Domingo | DOM | Right | Right | 5' 11" | 165 lbs | - |
| Sato, Tsuginori | SP | MSL Ft. Worth Cattlemen | 18 | 04/02/2035 | Machida | JPN | Left | Left | 6' 4" | 185 lbs | - |
| Scott, Paul | CL | MSL Toledo Stingers | 18 | 02/01/2035 | Plymouth | USA | Left | Left | 6' 4" | 190 lbs | - |
| Sellers, Edward | RF | MSL Baltimore Bullets | 17 | 02/13/2036 | Marbo Annex | GUM | Left | Left | 6' 5" | 195 lbs | - |
| Sim, Hi-gor | RP | MSL Baltimore Bullets | 18 | 07/24/2035 | Ulsan | KOR | Right | Right | 6' 5" | 190 lbs | - |
| Situ, Quan | SP | MSL Vancouver Grey Wolves | 18 | 12/15/2035 | Zalantun | CHN | Left | Right | 6' 2" | 180 lbs | - |
| Solís, Ramón | SP | MSL Colorado Billy Goats | 18 | 08/15/2035 | Cojutepeque | SLV | Left | Left | 6' 5" | 195 lbs | - |
| Sosa, Jorge | RP | MSL Vancouver Grey Wolves | 16 | 04/22/2037 | Chimaltenango | GUA | Right | Right | 5' 10" | 155 lbs | - |
| Stimson, Rio | RP | Free Agent | 18 | 06/01/2035 | London | ENG | Left | Left | 6' 2" | 170 lbs | - |
| Su-Tu, Wu-sheng | LF | MSL Baltimore Bullets | 18 | 01/27/2035 | Chongqing | CHN | Right | Right | 6' 2" | 185 lbs | - |
| Suzuki, Morihiro | RP | MSL Toledo Stingers | 18 | 07/09/2035 | Saitama | JPN | Right | Right | 6' 8" | 200 lbs | - |
| Szema, Zi-xing | 3B | MSL Oakland Oaks | 17 | 06/25/2036 | Putai | TPE | Right | Right | 6' 2" | 185 lbs | - |
| Sánchez, Esteban | SS | MSL Colorado Billy Goats | 18 | 09/07/2035 | Santo Domingo | DOM | Right | Right | 6' 4" | 175 lbs | - |
