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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sahagún, Júlio | 2B | Athletic Club KC Reserves | 33 | 11/23/2020 | El Estor | GUA | Right | Right | 6' 1" | 200 lbs | - |
| Saksansin, Poom | RP | Free Agent | 33 | 10/07/2020 | Chiang Khong | THA | Right | Right | 6' 3" | 200 lbs | - |
| Sanders, Wallace | SS | Alaskan Humpbacks | 30 | 02/17/2023 | Grove City | USA | Right | Right | 6' 1" | 205 lbs | - |
| Sang, Jung-jun | DH | Milton Dogfish Head | 26 | 10/06/2027 | Uijeongbu | KOR | Left | Left | 6' 4" | 200 lbs | $280,000 |
| Santos, Luis | 2B | Free Agent | 30 | 09/14/2023 | Holguín | CUB | Right | Right | 6' 0" | 200 lbs | - |
| Scott, Dave | SS | Bakersfield Nobles | 33 | 10/31/2020 | New York | USA | Switch | Right | 6' 0" | 180 lbs | $280,000 |
| Shantsev, Jov | 1B | Monongahela Monsters | 25 | 07/23/2028 | Moscow | RUS | Right | Right | 6' 0" | 200 lbs | - |
| Shirt, Robert | SP | Sioux Falls Red Pandas | 30 | 12/05/2023 | Spanish Town | JAM | Right | Right | 5' 11" | 200 lbs | - |
| Silva, Gilberto | RF | Bakersfield Nobles | 23 | 11/05/2030 | San Alejo | SLV | Right | Right | 6' 2" | 175 lbs | - |
| Silva, Norberto | SP | Syracuse Starks | 21 | 11/02/2032 | Torreón | MEX | Left | Left | 6' 3" | 180 lbs | $280,000 |
| Simmons, Gerald | SP | Baton Rouge Brass | 29 | 01/13/2024 | Scottsdale | USA | Right | Right | 6' 3" | 200 lbs | - |
| Simpson, John | 3B | Alaskan Humpbacks | 32 | 11/02/2021 | Memphis | USA | Right | Right | 5' 11" | 190 lbs | - |
| Sims, Dennis | RP | Baton Rouge Brass | 29 | 09/02/2024 | New York | USA | Right | Right | 6' 7" | 215 lbs | - |
| Situ, Zee-loo | 2B | Free Agent | 32 | 06/25/2021 | Shijiazhuang | CHN | Right | Right | 6' 1" | 200 lbs | - |
| Slaymaker, Lance | C | Bakersfield Nobles | 24 | 03/04/2029 | Akron | USA | Right | Right | 6' 0" | 200 lbs | $280,000 |
| Smith, Darryl | RP | Syracuse Starks | 23 | 12/14/2030 | Croydon | USA | Right | Right | 6' 1" | 185 lbs | $280,000 |
| Smith, Horace | RP | Athletic Club KC Reserves | 29 | 01/09/2024 | Los Angeles | USA | Right | Right | 6' 1" | 200 lbs | - |
| Sorondo, Julián | 1B | Sioux Falls Red Pandas | 29 | 12/05/2024 | Ciudad Bolívar | VEN | Left | Right | 6' 2" | 195 lbs | $12,500,000 |
| Springer, Mark | RP | Baton Rouge Brass | 30 | 01/03/2023 | Belle Chasse | USA | Left | Left | 6' 1" | 190 lbs | $280,000 |
| Stensel, Cenek | SP | Kansas Rainbeaus | 26 | 09/03/2027 | Nachod | CZE | Right | Right | 6' 3" | 200 lbs | - |
| Strain, Bill | SP | Syracuse Starks | 28 | 12/10/2025 | North Little Rock | USA | Left | Left | 6' 4" | 205 lbs | - |
| Sullivan, David | SP | Bakersfield Nobles | 26 | 07/03/2027 | Wolverine Lake | USA | Switch | Right | 6' 2" | 195 lbs | $280,000 |
| Sáenz, Orlando | LF | Syracuse Starks | 28 | 03/07/2025 | Santiago | DOM | Switch | Right | 5' 10" | 185 lbs | $280,000 |
| Sánchez, Juan | RP | Bakersfield Nobles | 23 | 01/31/2030 | Barcelona | VEN | Right | Right | 6' 2" | 185 lbs | $280,000 |
