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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saelices, Ángel | 2B | Free Agent | 33 | 02/10/2020 | Santo Domingo | DOM | Right | Right | 5' 9" | 200 lbs | - |
| Sainz, Carlos | RP | Seattle Rocketeers | 26 | 05/23/2027 | Madrid | ESP | Right | Right | 6' 2" | 200 lbs | $440,000 |
| Salgado, Víctor | C | Cape Coral Hurricanes | 23 | 07/27/2030 | La Romana | DOM | Right | Right | 6' 0" | 200 lbs | - |
| Samurakami, Okakura | 2B | Free Agent | 28 | 05/02/2025 | Nagaokakyo | JPN | Right | Right | 6' 1" | 190 lbs | - |
| Santos, José | SS | Toledo Stingers | 29 | 01/01/2024 | Santo Domingo | DOM | Switch | Right | 6' 1" | 200 lbs | $8,400,000 |
| Sato, Yamato | 1B | Free Agent | 32 | 10/01/2021 | Tokyo | JPN | Left | Left | 6' 0" | 205 lbs | - |
| Saunders, David | LF | Long Island Lighthouse | 25 | 08/26/2028 | Plymouth | USA | Left | Left | 6' 3" | 200 lbs | $280,000 |
| Schipper, Konrad | SP | Baltimore Bullets | 16 | 05/05/2037 | Willemstad | CUR | Right | Right | 6' 0" | 160 lbs | - |
| Scott, Elijah | 1B | Free Agent | 33 | 04/14/2020 | Kennesaw | USA | Left | Left | 6' 2" | 205 lbs | - |
| Serrano, Adrián | C | Toledo Stingers | 31 | 04/07/2022 | San Pedro de Macorís | DOM | Right | Right | 6' 0" | 205 lbs | $8,500,000 |
| Serrano, Jesús | 1B | Long Island Lighthouse | 23 | 04/23/2030 | Tegucigalpa | HON | Right | Right | 6' 4" | 185 lbs | $280,000 |
| Shini, Yaichiro | RP | Vancouver Grey Wolves | 29 | 09/27/2024 | Kashihara | JPN | Right | Right | 6' 6" | 200 lbs | $5,700,000 |
| Smith, Andrew | 1B | Toledo Stingers | 25 | 07/12/2028 | New River | USA | Left | Left | 6' 6" | 200 lbs | $280,000 |
| Smith, Jim | RP | Toledo Stingers | 23 | 05/11/2030 | Toledo | USA | Switch | Right | 6' 2" | 200 lbs | $280,000 |
| Smythe, Tom | RF | Vancouver Grey Wolves | 39 | 11/22/2014 | Thunder Bay | CAN | Right | Right | 6' 2" | 200 lbs | $350,000 |
| Snyder, Nick | SP | Oakland Oaks | 30 | 09/10/2023 | New York | USA | Left | Right | 6' 6" | 205 lbs | $12,000,000 |
| Soliman, Nestor | C | Ft. Worth Cattlemen | 29 | 08/21/2024 | Maragondon | PHI | Right | Right | 6' 2" | 200 lbs | $2,950,000 |
| Sotelo, Ernesto | SP | Long Island Lighthouse | 17 | 07/30/2036 | Colón | CRC | Right | Right | 6' 2" | 180 lbs | - |
| Soto, Jaime | 2B | Ft. Worth Cattlemen | 38 | 12/20/2015 | Santiago | CHI | Right | Right | 6' 1" | 205 lbs | $8,000,000 |
| Souza, Jorge | SP | Baltimore Bullets | 33 | 09/01/2020 | Villa Vazquez | DOM | Right | Right | 6' 1" | 200 lbs | $37,000,000 |
| Sprengel, Guonçalle | 2B | Long Island Lighthouse | 30 | 03/01/2023 | Carúpano | VEN | Right | Right | 6' 1" | 200 lbs | $280,000 |
| Sulander, Antti-Jussi | RF | Seattle Rocketeers | 24 | 04/17/2029 | Kiskorös | HUN | Left | Left | 6' 1" | 180 lbs | $280,000 |
| Swanton, Clive | CF | Free Agent | 29 | 12/23/2024 | Kingston | JAM | Right | Right | 6' 4" | 200 lbs | - |
