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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saelices, Juan Andrés | RP | Free Agent | 32 | 09/07/2020 | Gorham | USA | Right | Right | 6' 0" | 195 lbs | - |
| Sahagún, Júlio | 2B | Syracuse Starks | 32 | 11/23/2020 | El Estor | GUA | Right | Right | 6' 1" | 200 lbs | $280,000 |
| Saksansin, Poom | RP | Alaskan Humpbacks | 32 | 10/07/2020 | Chiang Khong | THA | Right | Right | 6' 3" | 205 lbs | - |
| Sanders, Homer | SP | Free Agent | 31 | 09/11/2021 | Philadelphia | USA | Right | Right | 6' 2" | 205 lbs | - |
| Sanders, Wallace | SS | Alaskan Humpbacks | 29 | 02/17/2023 | Grove City | USA | Right | Right | 6' 1" | 205 lbs | - |
| Santingo, Ángel | SP | Monongahela Monsters | 26 | 01/15/2026 | Santo Domingo | DOM | Right | Right | 5' 11" | 195 lbs | $280,000 |
| Scott, Gene | SP | Alaskan Humpbacks | 26 | 04/30/2026 | Denver | USA | Left | Right | 6' 4" | 210 lbs | - |
| Scroby, Tom | 2B | Free Agent | 29 | 10/26/2023 | Danielson | USA | Right | Right | 6' 0" | 200 lbs | - |
| Shantsev, Jov | 1B | Monongahela Monsters | 24 | 07/23/2028 | Moscow | RUS | Right | Right | 6' 0" | 205 lbs | - |
| Simpson, John | 3B | Alaskan Humpbacks | 31 | 11/02/2021 | Memphis | USA | Right | Right | 5' 11" | 195 lbs | - |
| Sin, Ki-moon | RP | Baton Rouge Brass | 23 | 01/26/2029 | Yeoju | KOR | Right | Right | 6' 3" | 185 lbs | $280,000 |
| Situ, Zee-loo | 2B | Syracuse Starks | 31 | 06/25/2021 | Shijiazhuang | CHN | Right | Right | 6' 1" | 205 lbs | - |
| Slaymaker, Lance | C | Bakersfield Nobles | 23 | 03/04/2029 | Akron | USA | Right | Right | 6' 0" | 200 lbs | - |
| Small, Chris | SP | Norfolk Pajaritos | 27 | 07/27/2025 | Cincinnati | USA | Left | Right | 6' 2" | 200 lbs | - |
| Smith, Dan | RP | Norfolk Pajaritos | 31 | 02/21/2021 | Somers Point | USA | Right | Right | 6' 0" | 200 lbs | - |
| Smith, Horace | RP | Athletic Club KC Reserves | 28 | 01/09/2024 | Los Angeles | USA | Right | Right | 6' 1" | 200 lbs | - |
| Sosa, Salvador | SP | Norfolk Pajaritos | 30 | 08/19/2022 | New York | USA | Right | Left | 6' 0" | 200 lbs | - |
| Spoelstra, Addy | DH | Bakersfield Nobles | 28 | 02/20/2024 | Sint Michiel | CUR | Left | Left | 6' 0" | 200 lbs | $280,000 |
| Springer, Mark | RP | Baton Rouge Brass | 29 | 01/03/2023 | Belle Chasse | USA | Left | Left | 6' 1" | 195 lbs | $280,000 |
| Stanley, John | CF | Norfolk Pajaritos | 25 | 10/12/2027 | Rochester | USA | Right | Right | 6' 0" | 190 lbs | - |
| Stewart, Nick | SP | Sunset District Fog | 22 | 01/29/2030 | Neenah | USA | Left | Left | 5' 11" | 175 lbs | - |
| Strain, Bill | SP | Syracuse Starks | 27 | 12/10/2025 | North Little Rock | USA | Left | Left | 6' 4" | 205 lbs | - |
| Suarez, Rafael | SS | Norfolk Pajaritos | 25 | 09/27/2027 | Pag-Asa | PHI | Right | Right | 6' 3" | 200 lbs | - |
| Sugimoto, Mitsuoki | SS | Bakersfield Nobles | 29 | 05/07/2023 | Matsudo | JPN | Left | Right | 6' 4" | 200 lbs | $580,000 |
| Sullivan, David | RP | Bakersfield Nobles | 25 | 07/03/2027 | Wolverine Lake | USA | Switch | Right | 6' 2" | 190 lbs | - |
| Swanson, Kevin | SP | Baton Rouge Brass | 25 | 06/18/2027 | Menomonie | USA | Switch | Right | 6' 4" | 200 lbs | $280,000 |
| Sánchez, Juan | RP | Bakersfield Nobles | 22 | 01/31/2030 | Barcelona | VEN | Right | Right | 6' 2" | 185 lbs | - |
| Sánchez, Tomás | 1B | Free Agent | 33 | 06/28/2019 | Santiago de Cuba | CUB | Switch | Left | 6' 0" | 200 lbs | - |
