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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, José | SP | Toledo Stingers | 16 | 06/02/2036 | Santo Domingo | DOM | Switch | Right | 5' 11" | 160 lbs | - |
| Salazaro, José | SP | Kingston Township Knights | 16 | 01/05/2036 | Tierra Blanca | CRC | Switch | Right | 6' 5" | 190 lbs | - |
| Sandison, Len | CF | Nova Scotia Leviathan | 30 | 10/13/2022 | Marion | USA | Left | Left | 6' 0" | 200 lbs | $6,000,000 |
| Sandoval, Carlos | SP | Detroit Elite | 25 | 10/20/2027 | Corredor | CRC | Right | Right | 6' 0" | 180 lbs | $460,000 |
| Santamarina, Doug | SP | St. Louis Coeur | 25 | 06/11/2027 | Belize | BLZ | Switch | Right | 6' 4" | 205 lbs | $280,000 |
| Saracho, Jaicus | CF | Kingston Township Knights | 28 | 02/28/2024 | Malasila | PHI | Right | Right | 6' 2" | 200 lbs | $280,000 |
| Sargent, Jerry | RP | Thunder Bay Northern Lions BC | 27 | 01/14/2025 | Indianapolis | USA | Right | Right | 6' 8" | 200 lbs | $550,000 |
| Sato, Mochihito | SP | Nova Scotia Leviathan | 28 | 04/16/2024 | Saitama | JPN | Right | Left | 6' 2" | 195 lbs | $280,000 |
| Saunders, Leonard | CF | Thunder Bay Northern Lions BC | 30 | 11/06/2022 | New York | USA | Right | Right | 6' 2" | 200 lbs | $280,000 |
| Schmitt, Damien | RP | Northern Virginia Rainbow Mermaids | 25 | 11/15/2027 | Civrieux-dAzergues | FRA | Right | Right | 6' 8" | 195 lbs | $280,000 |
| Scott, Steve | RF | Charleston Battery | 29 | 10/24/2023 | Red Hill | USA | Left | Left | 6' 2" | 200 lbs | $770,000 |
| Segura, Luis | C | D.C. Divided | 17 | 12/25/2035 | Caracas | VEN | Right | Right | 6' 4" | 200 lbs | - |
| Selkirk, Allan | C | Charleston Battery | 29 | 01/28/2023 | Sydney | AUS | Right | Right | 6' 0" | 200 lbs | $1,100,000 |
| Serrano, Adrián | C | Toledo Stingers | 30 | 04/07/2022 | San Pedro de Macorís | DOM | Right | Right | 6' 0" | 200 lbs | $8,500,000 |
| Seymour, Dan | SP | D.C. Divided | 32 | 03/04/2020 | Canton | USA | Right | Right | 6' 2" | 200 lbs | $650,000 |
| Shaw, Bobby | SP | Free Agent | 21 | 09/25/2031 | Bardstown | USA | Right | Right | 6' 4" | 195 lbs | - |
| Shini, Yaichiro | SP | Vancouver Grey Wolves | 28 | 09/27/2024 | Kashihara | JPN | Right | Right | 6' 6" | 200 lbs | $500,000 |
| Silva, Rafael | SP | Santa Catalina Condor | 17 | 02/15/2035 | San Miguelito | PAN | Right | Right | 6' 4" | 185 lbs | - |
| Sim, Hi-gor | SP | Northern Virginia Rainbow Mermaids | 17 | 07/24/2035 | Ulsan | KOR | Right | Right | 6' 5" | 190 lbs | - |
| Spencer, James | RP | Detroit Elite | 28 | 12/26/2024 | Camden | USA | Right | Right | 6' 0" | 200 lbs | $440,000 |
| Spilsbury, Bryan | C | Charleston Battery | 24 | 11/25/2028 | South Ockendon | ENG | Switch | Right | 6' 3" | 205 lbs | $280,000 |
| Starks, Conor | SP | Santa Catalina Condor | 28 | 03/06/2024 | Lévis | CAN | Switch | Right | 5' 9" | 195 lbs | $634,200 |
| Stinson, Hunter | SP | Charleston Battery | 23 | 10/28/2029 | Brooklyn | USA | Left | Left | 6' 2" | 200 lbs | $280,000 |
| Sáenz, Orlando | LF | Charleston Battery | 27 | 03/07/2025 | Santiago | DOM | Switch | Right | 5' 10" | 180 lbs | $1,890,000 |
| Sánchez, Leonardo | RP | Northern Virginia Rainbow Mermaids | 33 | 07/13/2019 | North Decatur | USA | Left | Right | 6' 0" | 200 lbs | $280,000 |
| Sánchez, Rubén | RP | Charleston Battery | 29 | 10/31/2023 | Santiago | CHI | Right | Right | 6' 3" | 200 lbs | $480,000 |
