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| Monday, October 23rd , 2051 |
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| MSL St. Louis Coeur: RP Boguljub Buturovic retired from professional baseball. |
| MSL D.C. Divided: Signed Pitching Coach Josh Parker to a 2-year contract extension. |
| MSL Toledo Stingers: Signed Hitting Coach Casey Walker to a 2-year contract extension. |
| MSL Toledo Stingers: Pitching Coach Kevin Farrales leaves the team, his contract was not renewed |
| MSL St. Louis Coeur: Hitting Coach Jorge González leaves the team, his contract was not renewed |
| Sunday, September 24th , 2051 |
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| MSL D.C. Divided: Released RP Mitchell Tromp. |
| MSL D.C. Divided: Released RP Emílio Ramírez. |
| Tuesday, September 5th , 2051 |
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| MSL Charleston Battery: Pitching Coach Thomas Brown retires. |
| MSL St. Louis Coeur: Activated 2B Xing-fu Tian from the injured list. |
