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| Monday, October 30th , 2051 |
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| Virginia Beach Whales: Signed Manager Marv Bradford. |
| Thursday, October 26th , 2051 |
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| Ithaca Fighting Imps: Signed Manager Albert Pérez. |
| Wednesday, October 25th , 2051 |
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| Ft. Polk South Thunder Hawks: Signed Manager Mike Evans. |
| Monday, October 23rd , 2051 |
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| Virginia Beach Whales: Released RP Richard Wood. |
| Virginia Beach Whales: Released SS Edmund Benson. |
| Virginia Beach Whales: Released CF Terry Valdéz. |
| Squirrel Hill Pierogis: 1B Dave Blankenship retired from professional baseball. |
| Gulf Coast Turbeaus: SP Bob Carlile retired from professional baseball. |
| Gwinnett Guinea Pigs: RP Héctor Gómez retired from professional baseball. |
| Mercer Island Screaming Eagles: RP Jeff Floyd retired from professional baseball. |
| Mercer Island Screaming Eagles: C Juan Tilve retired from professional baseball. |
| Ithaca Fighting Imps: LF José López retired from professional baseball. |
| Gulf Coast Turbeaus: SS Jae-keol Om retired from professional baseball. |
| Mercer Island Screaming Eagles: CF Lasse Karsberg retired from professional baseball. |
| Gwinnett Guinea Pigs: LF Slavko Boskovic retired from professional baseball. |
| Ithaca Fighting Imps: 3B Larry Thompson retired from professional baseball. |
| Squirrel Hill Pierogis: RP Chris McGee retired from professional baseball. |
| Mercer Island Screaming Eagles: 2B Máximo Zubiete retired from professional baseball. |
| Gulf Coast Turbeaus: RP Kanne Kaspers retired from professional baseball. |
| Gulf Coast Turbeaus: RP Roberto Vázquez retired from professional baseball. |
| Mercer Island Screaming Eagles: RP Ed Cameron retired from professional baseball. |
| Gulf Coast Turbeaus: RF Reynaldo Juárez retired from professional baseball. |
| Athletic Club KC Academy: RP Hai-liang Shuang retired from professional baseball. |
| Virginia Beach Whales: CF Terry Valdéz retired from professional baseball. |
| Squirrel Hill Pierogis: RP Joe Hurst retired from professional baseball. |
| Mercer Island Screaming Eagles: RP Alan Gonzáles retired from professional baseball. |
| Mercer Island Screaming Eagles: 1B Charles Barnes retired from professional baseball. |
| Virginia Beach Whales: RP Richard Wood retired from professional baseball. |
| Mercer Island Screaming Eagles: LF Carlos Delgard retired from professional baseball. |
| Mercer Island Screaming Eagles: RF Esteban Mogollón retired from professional baseball. |
| Gulf Coast Turbeaus: LF Bill John retired from professional baseball. |
| Squirrel Hill Pierogis: SP Clayton Thomas retired from professional baseball. |
| Mercer Island Screaming Eagles: RP Je-ju Pak retired from professional baseball. |
| Virginia Beach Whales: Manager Domingo García retires. |
| Athletic Club KC Academy: Pitching Coach Félix Jiménez leaves the team, his contract was not renewed |
| Athletic Club KC Academy: Hitting Coach Jim Bunker leaves the team, his contract was not renewed |
| Virginia Beach Whales: Hitting Coach Guy Riley leaves the team, his contract was not renewed |
| Gulf Coast Turbeaus: Manager León Domínguez leaves the team, his contract was not renewed |
| Gulf Coast Turbeaus: Hitting Coach Dennis O'Connor leaves the team, his contract was not renewed |
| Gwinnett Guinea Pigs: Hitting Coach Allen Courtney leaves the team, his contract was not renewed |
| Sunday, September 24th , 2051 |
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| Virginia Beach Whales: Activated RP Gavriil Wolfson from the injured list. |
| Ft. Polk South Thunder Hawks: Manager Hiroji Nakagawa retires. |
| Ithaca Fighting Imps: Manager Gary Thomas retires. |
