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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saelices, Juan Andrés | RP | Free Agent | 31 | 09/07/2020 | Gorham | USA | Right | Right | 6' 0" | 195 lbs | - |
| Sahagún, Júlio | 2B | Syracuse Starks | 31 | 11/23/2020 | El Estor | GUA | Right | Right | 6' 1" | 200 lbs | - |
| Saksansin, Poom | RP | Alaskan Humpbacks | 31 | 10/07/2020 | Chiang Khong | THA | Right | Right | 6' 3" | 205 lbs | - |
| Sanders, Homer | SP | Free Agent | 30 | 09/11/2021 | Philadelphia | USA | Right | Right | 6' 2" | 205 lbs | - |
| Sanford, Steve | SP | Free Agent | 28 | 10/22/2023 | Berwick | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sangrey, Thomas | RP | Syracuse Squirrel Monkeys | 32 | 03/29/2019 | Madison | USA | Right | Right | 5' 10" | 195 lbs | - |
| Schock, Justin | 2B | Syracuse Squirrel Monkeys | 31 | 06/21/2020 | Palm Bay | USA | Right | Right | 6' 3" | 200 lbs | - |
| Schreibvogel, Joe | 1B | Syracuse Starks | 34 | 10/05/2017 | Garden City | USA | Left | Right | 6' 2" | 210 lbs | $280,000 |
| Scott, Dave | SS | Bakersfield Nobles | 31 | 10/31/2020 | New York | USA | Switch | Right | 6' 0" | 180 lbs | - |
| Scott, Gene | SP | Alaskan Humpbacks | 25 | 04/30/2026 | Denver | USA | Left | Right | 6' 4" | 210 lbs | - |
| Scotton, Bertrand | RP | Bakersfield Nobles | 32 | 12/30/2019 | Savanna la Mar | JAM | Right | Right | 6' 1" | 195 lbs | $800,000 |
| Secci, Ernesto | CF | Baton Rouge Brass | 28 | 04/18/2023 | Buenos Aires | ARG | Right | Right | 6' 1" | 200 lbs | - |
| Shepard, Michael | SP | Alaskan Humpbacks | 26 | 09/29/2025 | Brownsville | USA | Right | Right | 6' 2" | 200 lbs | - |
| Shimada, Orinosuke | CF | Free Agent | 28 | 12/20/2023 | Fukuoka | JPN | Right | Right | 6' 0" | 200 lbs | - |
| Silva, Mario | SP | Free Agent | 33 | 07/10/2018 | Sparta | USA | Right | Right | 6' 1" | 200 lbs | - |
| Simpson, John | 3B | Alaskan Humpbacks | 30 | 11/02/2021 | Memphis | USA | Right | Right | 5' 11" | 195 lbs | - |
| Situ, Zee-loo | 2B | Syracuse Starks | 30 | 06/25/2021 | Shijiazhuang | CHN | Right | Right | 6' 1" | 205 lbs | - |
| Smith, Horace | RP | Athletic Club KC Reserves | 27 | 01/09/2024 | Los Angeles | USA | Right | Right | 6' 1" | 195 lbs | - |
| Sosa, Salvador | SP | Free Agent | 29 | 08/19/2022 | New York | USA | Right | Left | 6' 0" | 195 lbs | - |
| Souza, Jorge | SP | Alaskan Humpbacks | 23 | 10/25/2028 | Ballston Spa | USA | Left | Left | 6' 1" | 195 lbs | - |
| Spoelstra, Addy | DH | Bakersfield Nobles | 27 | 02/20/2024 | Sint Michiel | CUR | Left | Left | 6' 0" | 200 lbs | $280,000 |
| Springer, Mark | RP | Baton Rouge Brass | 28 | 01/03/2023 | Belle Chasse | USA | Left | Left | 6' 1" | 195 lbs | - |
| Strain, Bill | SP | Syracuse Starks | 26 | 12/10/2025 | North Little Rock | USA | Left | Left | 6' 4" | 205 lbs | - |
| Stuart, Bailey | CF | Alaskan Humpbacks | 29 | 08/18/2022 | Neston | ENG | Switch | Right | 6' 2" | 195 lbs | - |
| Sullivan, David | RP | Bakersfield Nobles | 24 | 07/03/2027 | Wolverine Lake | USA | Switch | Right | 6' 2" | 190 lbs | - |
| Surtees, Albert | SP | Syracuse Squirrel Monkeys | 27 | 08/24/2024 | Oldham | ENG | Right | Right | 6' 7" | 205 lbs | - |
| Sánchez, Jorge | C | Kansas Rainbeaus | 26 | 08/09/2025 | Consuelo | DOM | Right | Right | 6' 1" | 200 lbs | $280,000 |
| Sánchez, Juan | RP | Bakersfield Nobles | 21 | 01/31/2030 | Barcelona | VEN | Right | Right | 6' 2" | 180 lbs | - |
| Sánchez, Roberto | SP | Sacramento Redlegs | 22 | 07/06/2029 | Santo Domingo | DOM | Right | Right | 6' 6" | 200 lbs | - |
| Sánchez, Tomás | 1B | Free Agent | 32 | 06/28/2019 | Santiago de Cuba | CUB | Switch | Left | 6' 0" | 200 lbs | - |
