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| Monday, November 1st , 2049 |
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| MSL Oakland Oaks: Signed Manager Milton Mathews. |
| Sunday, October 24th , 2049 |
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| MSL Oakland Oaks: Hitting Coach Ray Bane leaves the team, his contract was not renewed |
| MSL Oakland Oaks: Pitching Coach Kyeong-min Ki leaves the team, his contract was not renewed |
| MSL Buckhead Bowties: Pitching Coach Jon Norman leaves the team, his contract was not renewed |
| MSL Buckhead Bowties: Hitting Coach Álex Gutiérrez leaves the team, his contract was not renewed |
| MSL Kingston Township Knights: Hitting Coach Frank Wentworth leaves the team, his contract was not renewed |
| MSL Kingston Township Knights: Pitching Coach Eric Craft leaves the team, his contract was not renewed |
| MSL D.C. Divided: Signed Pitching Coach Josh Parker to a 2-year contract extension. |
| MSL Toledo Stingers: Signed Hitting Coach Casey Walker to a 2-year contract extension. |
| MSL Toledo Stingers: Signed Manager Álex Burgos to a 3-year contract extension. |
| MSL Toledo Stingers: Signed Pitching Coach Kevin Farrales to a 2-year contract extension. |
| MSL Montana Pandas: Hitting Coach Greg Brode leaves the team, his contract was not renewed |
| MSL Montana Pandas: Pitching Coach José Ramírez leaves the team, his contract was not renewed |
| Saturday, September 25th , 2049 |
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| MSL D.C. Divided: Released RP Toshio Inoue. |
| MSL D.C. Divided: Released 2B Miguel Méndez. |
| Friday, September 24th , 2049 |
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| MSL D.C. Divided: Released RP Timo Nikkanen. |
| Sunday, September 12th , 2049 |
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| MSL D.C. Divided: Released RP Pablo Gonzáles. |
| MSL Panama City Piranhas: Signed -name %name to a %number-year contract extension. |
| Wednesday, September 8th , 2049 |
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| MSL Nashville Outlaws: Released RP Juan Velázquez. |
| MSL D.C. Divided: Released RP Fa-tang Chen. |
| Tuesday, September 7th , 2049 |
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| MSL Nashville Outlaws: Released RP Dennis Leslie. |
| MSL Nashville Outlaws: Released RP Júlio Madrigal. |
| MSL D.C. Divided: Released RP Doug Glenn. |
| Monday, September 6th , 2049 |
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| MSL Nashville Outlaws: Activated RP Jesús Guzmán from the injured list. |
| MSL Nashville Outlaws: Activated RF Willard Palmer from the injured list. |
| MSL Nashville Outlaws: Released RP Ramón Cardenas. |
| MSL Nashville Outlaws: Released RP Dani Corona. |
| MSL D.C. Divided: Activated RP Jaime Martínez from the injured list. |
| MSL D.C. Divided: Activated SS Dusty Donaldson from the injured list. |
| MSL D.C. Divided: Released RP Billy McCullough. |
| MSL Nashville Outlaws: Released RP Sancho Morales. |
