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| Sunday, October 24th , 2049 |
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| Fort Knox Centennial: SP Miguel Silva retired from professional baseball. |
| Flint Crush: RP Enrico Flores retired from professional baseball. |
| Plattsburgh Puffer Fish: SS Glenn Nelson retired from professional baseball. |
| Germantown Uruguayans: CF Mauro Muñóz retired from professional baseball. |
| Ladue Rams: 2B Alfredo Caro retired from professional baseball. |
| Bethlehem Angel Kitties: 3B Francisco Peña retired from professional baseball. |
| Germantown Uruguayans: C Wing Wa retired from professional baseball. |
| Germantown Uruguayans: RP Deviprasada Tirumalesa retired from professional baseball. |
| Bompton Baby Lakers: Signed Pitching Coach Carlos Méndez to a 2-year contract extension. |
| Bethlehem Angel Kitties: Hitting Coach Edward Carlson leaves the team, his contract was not renewed |
| Bethlehem Angel Kitties: Pitching Coach José Castillo leaves the team, his contract was not renewed |
| Amarillo Warheads: Hitting Coach José Marín leaves the team, his contract was not renewed |
| Tuesday, September 21st , 2049 |
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| Bompton Baby Lakers: Signed Manager Júlio Villegas. |
| Monday, September 13th , 2049 |
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| Bompton Baby Lakers: Manager Vernon Anderson retires. |
