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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saelices, Juan Andrés | RP | Free Agent | 28 | 09/07/2020 | Gorham | USA | Right | Right | 6' 0" | 195 lbs | - |
| Saelices, Ángel | 2B | Northern Virginia Rainbow Mermaids | 28 | 02/10/2020 | Santo Domingo | DOM | Right | Right | 5' 9" | 185 lbs | $9,400,000 |
| Sahagún, Júlio | 2B | San Mateo Dirty Reds | 28 | 11/23/2020 | El Estor | GUA | Right | Right | 6' 1" | 200 lbs | $8,000,000 |
| Sai, Sumitomo | SP | Northern Virginia Rainbow Mermaids | 18 | 11/30/2030 | Anjo | JPN | Right | Right | 6' 1" | 175 lbs | - |
| Salgado, José | SP | Hollywood Shredders | 16 | 06/12/2032 | Villa Altagracia | DOM | Left | Left | 6' 1" | 170 lbs | - |
| Sampang, Arvin | RP | Free Agent | 19 | 03/06/2029 | Victorias | PHI | Left | Right | 6' 2" | 175 lbs | - |
| Sandison, Len | CF | Nova Scotia Leviathan | 26 | 10/13/2022 | Marion | USA | Left | Left | 6' 0" | 190 lbs | $280,000 |
| Sandoval, Juan Carlos | SP | Free Agent | 17 | 08/20/2031 | Lady Lake | USA | Right | Right | 6' 3" | 180 lbs | - |
| Sato, Yamato | 1B | Hollywood Shredders | 27 | 10/01/2021 | Tokyo | JPN | Left | Left | 6' 0" | 215 lbs | $13,600,000 |
| Schaller, Ari | RP | St. Louis Coeur | 27 | 04/20/2021 | Eggendorf | AUT | Right | Right | 6' 1" | 195 lbs | $280,000 |
| Scotton, Bertrand | RP | Boston Patriots | 29 | 12/30/2019 | Savanna la Mar | JAM | Right | Right | 6' 1" | 190 lbs | $1,236,000 |
| Security, Maxwell | RP | Vancouver Grey Wolves | 30 | 10/06/2018 | Dallas | USA | Right | Right | 6' 2" | 200 lbs | $280,000 |
| Sedin, Andor | SP | Free Agent | 26 | 10/22/2022 | Tulsa | USA | Left | Left | 6' 2" | 200 lbs | - |
| Serrano, Adrián | C | Hollywood Shredders | 26 | 04/07/2022 | San Pedro de Macorís | DOM | Right | Right | 6' 0" | 200 lbs | $530,000 |
| Seymour, Todd | 3B | Free Agent | 23 | 02/12/2025 | Nashville | USA | Right | Right | 6' 3" | 200 lbs | - |
| Shaw, Bobby | SP | Free Agent | 17 | 09/25/2031 | Bardstown | USA | Right | Right | 6' 4" | 190 lbs | - |
| Shaw, Bobby | SP | Free Agent | 30 | 10/17/2018 | Parkwood | USA | Right | Right | 6' 1" | 200 lbs | - |
| Shini, Yaichiro | SP | Vancouver Grey Wolves | 24 | 09/27/2024 | Kashihara | JPN | Right | Right | 6' 6" | 200 lbs | $280,000 |
| Sierra, Jesús | CF | Free Agent | 24 | 05/06/2024 | Fremont | USA | Right | Left | 6' 0" | 200 lbs | - |
| Sifuentes, Esteban | RF | San Mateo Dirty Reds | 27 | 03/21/2021 | Mexico City | MEX | Left | Left | 6' 2" | 200 lbs | $6,000,000 |
| Silva, Jesús | SP | Greenville 84s | 34 | 06/15/2014 | Newbury | USA | Right | Right | 6' 6" | 220 lbs | $28,200,000 |
| Slaybaugh, Jason | 1B | Free Agent | 36 | 11/10/2012 | Austin | USA | Right | Right | 6' 2" | 215 lbs | - |
| Slooters, Peer | SP | San Mateo Dirty Reds | 30 | 01/10/2018 | Willemstad | CUR | Right | Right | 6' 4" | 195 lbs | $7,000,000 |
| Small, Benny | SP | Free Agent | 16 | 03/02/2032 | Wyckoff | USA | Right | Right | 6' 4" | 180 lbs | - |
| Smith, Barrett | RP | Free Agent | 30 | 12/22/2018 | Los Angeles | USA | Right | Right | 6' 2" | 205 lbs | - |
| Smith, Randy | RP | Mississippi Mockingbirds | 25 | 10/08/2023 | Hawthorne | USA | Right | Right | 6' 3" | 200 lbs | $280,000 |
| Smythe, Tom | CF | Hollywood Shredders | 34 | 11/22/2014 | Thunder Bay | CAN | Right | Right | 6' 2" | 200 lbs | $10,000,000 |
| Soto, Jaime | 2B | Vancouver Grey Wolves | 33 | 12/20/2015 | Santiago | CHI | Right | Right | 6' 1" | 195 lbs | $12,000,000 |
| Spadina, Chuck | RP | Northern Virginia Rainbow Mermaids | 27 | 08/10/2021 | Redwood City | USA | Left | Right | 6' 0" | 200 lbs | $480,000 |
| Stirzacre, Everton | RP | Nova Scotia Leviathan | 27 | 06/14/2021 | Somersham | ENG | Left | Left | 6' 4" | 200 lbs | $280,000 |
| Stitt, Ron | C | Free Agent | 17 | 09/15/2031 | Westminster | USA | Switch | Right | 6' 2" | 200 lbs | - |
| Strickland, Jeffrey | RP | Athletic Club KC | 27 | 01/26/2021 | St. Cloud | USA | Right | Right | 6' 3" | 200 lbs | $280,000 |
| Suggett, Glenn | SP | Boston Patriots | 33 | 09/27/2015 | Los Angeles | USA | Right | Right | 6' 1" | 200 lbs | $9,000,000 |
| Sugimoto, Mitsuoki | 2B | Hollywood Shredders | 25 | 05/07/2023 | Matsudo | JPN | Left | Right | 6' 4" | 200 lbs | $7,700,000 |
| Sui, Yifu | SP | Free Agent | 22 | 01/06/2026 | New York | USA | Left | Left | 5' 10" | 180 lbs | - |
| Suzuki, Yo | SP | San Mateo Dirty Reds | 16 | 03/20/2032 | Imabari | JPN | Right | Left | 6' 1" | 165 lbs | - |
| Swan, Ishaan | LF | Greenville 84s | 22 | 01/07/2026 | St. George | BER | Left | Right | 6' 0" | 170 lbs | $280,000 |
| Swanson, Doug | RP | Greenville 84s | 28 | 06/01/2020 | Harrisburg | USA | Left | Left | 6' 1" | 200 lbs | $560,000 |
| Sánchez, Armando | SP | Free Agent | 20 | 06/13/2028 | Rialto | USA | Right | Right | 5' 9" | 165 lbs | - |
