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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sanders, Dan | SP | Austin Black Mambas | 29 | 09/09/2018 | Dunstable | USA | Right | Right | 6' 1" | 200 lbs | - |
| Sanford, Steve | SP | Port Huron Blitzkrieg | 24 | 10/22/2023 | Berwick | USA | Right | Right | 6' 2" | 200 lbs | - |
| Santana, Rodrigo | 3B | Monongahela Monsters | 30 | 12/28/2017 | San Diego | USA | Switch | Right | 5' 11" | 200 lbs | - |
| Santingo, Ángel | SP | Monongahela Monsters | 21 | 01/15/2026 | Santo Domingo | DOM | Right | Right | 5' 11" | 175 lbs | - |
| Santos, José | RP | Port Huron Blitzkrieg | 33 | 07/13/2014 | Los Angeles | USA | Left | Left | 6' 1" | 205 lbs | - |
| Santos, Luis | 2B | Sioux Falls Red Pandas | 24 | 09/14/2023 | Holguín | CUB | Right | Right | 6' 0" | 200 lbs | - |
| Saraf, Barsati | 2B | Free Agent | 31 | 04/28/2016 | Springs | RSA | Right | Right | 5' 11" | 200 lbs | - |
| Sarcoma, Broderick | 2B | Hialeah Dodos | 33 | 08/13/2014 | Mayagüez | PUR | Right | Right | 5' 10" | 200 lbs | - |
| Sariana, Ánibal | 2B | Free Agent | 25 | 01/25/2022 | Ciudad Guayana | VEN | Right | Right | 6' 2" | 195 lbs | - |
| Sastre, Luis | SP | Free Agent | 29 | 06/03/2018 | La Mata | DOM | Right | Right | 6' 5" | 200 lbs | - |
| Schmidt, Kelvin | 1B | Free Agent | 28 | 08/06/2019 | Cul De Sac | SIM | Left | Right | 6' 1" | 200 lbs | - |
| Schock, Justin | 3B | Syracuse Squirrel Monkeys | 27 | 06/21/2020 | Palm Bay | USA | Right | Right | 6' 3" | 200 lbs | - |
| Schulte, Steffen | CF | Austin Black Mambas | 29 | 07/01/2018 | Dallastown | USA | Right | Right | 6' 0" | 195 lbs | - |
| Scroby, Tom | 2B | Port Huron Blitzkrieg | 24 | 10/26/2023 | Danielson | USA | Right | Right | 6' 0" | 190 lbs | - |
| Sierra, Javier | 1B | Norfolk Pajaritos | 38 | 09/11/2009 | Florida | CUB | Right | Left | 6' 6" | 225 lbs | $1,200,000 |
| Sims, Nick | C | Pawnee ParksNRec | 27 | 12/09/2020 | Hackensack | USA | Right | Right | 6' 2" | 205 lbs | - |
| Sin, Man-su | LF | Austin Black Mambas | 29 | 03/13/2018 | Sunchon | PRK | Left | Left | 6' 2" | 200 lbs | - |
| Slaughter, Bill | SP | Pawnee ParksNRec | 27 | 05/27/2020 | Markham | USA | Right | Right | 5' 11" | 195 lbs | $280,000 |
| Solís, Javier | RP | Sioux Falls Red Pandas | 28 | 03/28/2019 | San Miguel Chicaj | GUA | Switch | Right | 6' 4" | 195 lbs | - |
| Son, Kyung-chul | SS | Monongahela Monsters | 23 | 12/03/2024 | Seoul | KOR | Left | Right | 6' 0" | 170 lbs | - |
| Sparks, Clyde | RP | Hialeah Dodos | 31 | 05/07/2016 | Casper | USA | Right | Right | 6' 0" | 200 lbs | - |
| Spencer, James | CL | Port Huron Blitzkrieg | 23 | 12/26/2024 | Camden | USA | Right | Right | 6' 0" | 195 lbs | - |
| Stephens, Phil | RP | Port Huron Blitzkrieg | 28 | 01/05/2019 | Whitney | USA | Right | Left | 5' 10" | 190 lbs | - |
| Steur, Gustaf | RP | Monongahela Monsters | 24 | 08/21/2023 | Willemstad | CUR | Left | Right | 6' 6" | 205 lbs | $280,000 |
| Stevenson, Charles | SS | Kansas Rainbeaus | 25 | 03/08/2022 | Plano | USA | Right | Right | 6' 0" | 185 lbs | - |
| Swetnam, Edward | RP | Sioux Falls Red Pandas | 26 | 06/22/2021 | Charlotte Amalie | VIR | Right | Right | 6' 2" | 200 lbs | $280,000 |
