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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sa'id, Reda | SP | D.C. Divided | 17 | 11/01/2030 | Qazrin | ISR | Switch | Right | 5' 10" | 160 lbs | - |
| Sai, Arata | SP | Montana Pandas | 17 | 02/18/2030 | Tokyo | JPN | Right | Right | 6' 2" | 180 lbs | - |
| Sainz, Eduardo | C | D.C. Divided | 27 | 11/06/2020 | Santa Ana | CRC | Right | Right | 6' 0" | 195 lbs | $280,000 |
| Salazar, Germán | 2B | Free Agent | 17 | 08/05/2030 | Santo Domingo | DOM | Switch | Right | 6' 2" | 180 lbs | - |
| Salazar, Júlio | LF | Pittsburgh Kingfishers | 34 | 06/14/2013 | Ciego de Avila | CUB | Right | Right | 5' 10" | 200 lbs | $280,000 |
| Salviati, Valerio | CF | D.C. Divided | 25 | 06/25/2022 | Sabara | BRA | Right | Right | 6' 2" | 180 lbs | $280,000 |
| San Pedro, Tony | C | Echo Park Lakers | 26 | 04/29/2021 | San Pedro Sula | HON | Left | Right | 6' 0" | 200 lbs | $280,000 |
| Sandoval, César | SP | Baltimore Bullets | 34 | 08/28/2013 | Sancti Spíritus | CUB | Right | Right | 6' 2" | 200 lbs | $1,700,000 |
| Scalfaro, Camillo | 1B | Free Agent | 20 | 02/19/2027 | Fermo | ITA | Right | Right | 6' 3" | 205 lbs | - |
| Schep, Andrej | RP | Free Agent | 19 | 03/19/2028 | Cul De Sac | SIM | Left | Left | 6' 4" | 185 lbs | - |
| Schepers, Noud | SP | D.C. Divided | 17 | 01/05/2030 | Oranjestad | ARU | Right | Right | 6' 2" | 175 lbs | - |
| Schreibvogel, Joe | 1B | Echo Park Lakers | 30 | 10/05/2017 | Garden City | USA | Left | Right | 6' 2" | 235 lbs | $3,550,000 |
| Schweitzer, Laurent | RP | Detroit Elite | 27 | 09/16/2020 | Toronto | CAN | Left | Right | 6' 3" | 215 lbs | $280,000 |
| Scott, Elijah | 1B | Echo Park Lakers | 27 | 04/14/2020 | Kennesaw | USA | Left | Left | 6' 2" | 210 lbs | $280,000 |
| Scott, Jerry | RF | Colorado Billy Goats | 29 | 01/25/2018 | Elizabethtown | USA | Right | Right | 6' 2" | 200 lbs | $280,000 |
| Scott, Mike | 2B | Detroit Elite | 28 | 12/29/2019 | San Antonio | USA | Left | Right | 6' 0" | 195 lbs | $280,000 |
| Seletto, Bonifazio | SP | Pittsburgh Kingfishers | 16 | 01/23/2031 | Rosario | ARG | Right | Right | 6' 2" | 170 lbs | - |
| Serano, Pedro | 1B | Toledo Stingers | 33 | 05/13/2014 | Prairie Village | USA | Left | Left | 6' 6" | 250 lbs | $7,150,000 |
| Shepard, Colton | C | Toledo Stingers | 27 | 02/01/2020 | Bensenville | USA | Right | Right | 6' 3" | 205 lbs | $2,200,000 |
| Sierra, Héctor | 3B | Toledo Stingers | 18 | 09/30/2029 | La Vega | DOM | Right | Right | 6' 1" | 185 lbs | - |
| Sifuentes, Esteban | RF | San Mateo Dirty Reds | 26 | 03/21/2021 | Mexico City | MEX | Left | Left | 6' 2" | 200 lbs | $6,000,000 |
| Silva, Roberto | SP | Baltimore Bullets | 18 | 06/13/2029 | Camagüey | CUB | Left | Left | 6' 4" | 190 lbs | - |
| Sinclair, Max | RF | Pittsburgh Kingfishers | 28 | 02/21/2019 | North Canton | USA | Left | Left | 6' 1" | 185 lbs | $2,520,000 |
| Situ, Zee-loo | 2B | Montana Pandas | 26 | 06/25/2021 | Shijiazhuang | CHN | Right | Right | 6' 1" | 200 lbs | $280,000 |
| Slaybaugh, Jason | 1B | San Mateo Dirty Reds | 35 | 11/10/2012 | Austin | USA | Right | Right | 6' 2" | 215 lbs | $21,000,000 |
| Smith, Randy | CL | Mississippi Mockingbirds | 24 | 10/08/2023 | Hawthorne | USA | Right | Right | 6' 3" | 195 lbs | $280,000 |
| Soliman, Nestor | C | Baltimore Bullets | 23 | 08/21/2024 | Maragondon | PHI | Right | Right | 6' 2" | 195 lbs | $280,000 |
| Sosa, José | SS | Mississippi Mockingbirds | 16 | 05/02/2031 | Quilalí | NCA | Switch | Right | 6' 4" | 180 lbs | - |
| Soto, Eduardo | SP | D.C. Divided | 17 | 02/10/2030 | Ecatepec | MEX | Left | Left | 6' 2" | 180 lbs | - |
| Souza, José | SP | Baltimore Bullets | 18 | 11/17/2029 | Santo Domingo | DOM | Right | Right | 6' 0" | 170 lbs | - |
| Spaan, Gerben | RF | Echo Park Lakers | 19 | 01/26/2028 | Cul De Sac | SIM | Left | Left | 6' 3" | 195 lbs | - |
| Spronck, Chiel | RF | Colorado Billy Goats | 23 | 03/18/2024 | Willemstad | CUR | Right | Right | 6' 2" | 180 lbs | $280,000 |
| Sterrenburg, Edward | 1B | Pittsburgh Kingfishers | 36 | 02/07/2011 | Willemstad | CUR | Switch | Right | 6' 4" | 220 lbs | $3,500,000 |
| Sánchez, José | 2B | Free Agent | 17 | 10/18/2030 | Lagunillas | VEN | Right | Right | 6' 2" | 175 lbs | - |
| Sánchez, Raúl | CF | Montana Pandas | 17 | 11/09/2030 | San Isidro | CRC | Switch | Right | 6' 1" | 180 lbs | - |
| Sánchez, Rubén | SP | D.C. Divided | 24 | 10/31/2023 | Santiago | CHI | Right | Right | 6' 3" | 195 lbs | $280,000 |
| Sánchez, Tomás | 1B | Colorado Billy Goats | 28 | 06/28/2019 | Santiago de Cuba | CUB | Switch | Left | 6' 0" | 200 lbs | $280,000 |
