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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sainz, Eduardo | C | Pawnee ParksNRec | 25 | 11/06/2020 | Santa Ana | CRC | Right | Right | 6' 0" | 195 lbs | - |
| Salazar, Júlio | LF | Syracuse Squirrel Monkeys | 32 | 06/14/2013 | Ciego de Avila | CUB | Right | Right | 5' 10" | 200 lbs | $1,200,000 |
| Salt, Jack | RP | Norfolk Pajaritos | 34 | 03/29/2011 | Manassas | USA | Right | Right | 6' 4" | 220 lbs | $280,000 |
| Sangrey, Thomas | RP | Syracuse Squirrel Monkeys | 26 | 03/29/2019 | Madison | USA | Right | Right | 5' 10" | 185 lbs | $280,000 |
| Santana, Rubén | SP | Milton Dogfish Head | 26 | 06/03/2019 | Hartshorne | USA | Switch | Right | 6' 4" | 210 lbs | - |
| Santos, José | SS | Milton Dogfish Head | 21 | 01/01/2024 | Santo Domingo | DOM | Switch | Right | 6' 1" | 175 lbs | $280,000 |
| Sapinoso, Juan | RF | Milton Dogfish Head | 23 | 05/27/2022 | Puerto Plata | DOM | Left | Left | 6' 1" | 195 lbs | - |
| Sarcoma, Broderick | 2B | Hialeah Dodos | 31 | 08/13/2014 | Mayagüez | PUR | Right | Right | 5' 10" | 195 lbs | - |
| Sastre, Luis | SP | Syracuse Squirrel Monkeys | 27 | 06/03/2018 | La Mata | DOM | Right | Right | 6' 5" | 205 lbs | $280,000 |
| Sato, Aki | RP | Hamilton Coyotes | 32 | 04/20/2013 | Mito | JPN | Right | Right | 6' 2" | 230 lbs | $490,000 |
| Saunders, Carl | LF | Ellenburg Fighting Dachsunds | 29 | 05/24/2016 | Gresham | USA | Switch | Right | 6' 1" | 205 lbs | - |
| Schock, Justin | 3B | Syracuse Squirrel Monkeys | 25 | 06/21/2020 | Palm Bay | USA | Right | Right | 6' 3" | 200 lbs | - |
| Schroeder, Chandler | LF | Syracuse Squirrel Monkeys | 24 | 11/25/2021 | Boulder | USA | Left | Left | 6' 4" | 205 lbs | - |
| Semprún, Carlos | SP | Norfolk Pajaritos | 25 | 03/04/2020 | Santo Domingo | DOM | Left | Left | 6' 4" | 200 lbs | - |
| Shamakani, Dean | 1B | Free Agent | 28 | 07/06/2017 | George | RSA | Right | Right | 6' 3" | 205 lbs | - |
| Silva, Ángel | SP | Norfolk Pajaritos | 32 | 01/11/2013 | Santo Domingo | DOM | Left | Left | 5' 10" | 185 lbs | - |
| Simic, Pavle | RP | Pawnee ParksNRec | 32 | 06/10/2013 | Botevgrad | BUL | Right | Left | 6' 7" | 220 lbs | $550,000 |
| Slaughter, Bill | SP | Pawnee ParksNRec | 25 | 05/27/2020 | Markham | USA | Right | Right | 5' 11" | 190 lbs | - |
| Snodgrass, Roger | 3B | Free Agent | 32 | 10/27/2013 | New York | USA | Right | Right | 6' 4" | 245 lbs | - |
| Soliman, Nestor | C | Norfolk Pajaritos | 21 | 08/21/2024 | Maragondon | PHI | Right | Right | 6' 2" | 190 lbs | - |
| Sparks, Clyde | SP | Hialeah Dodos | 29 | 05/07/2016 | Casper | USA | Right | Right | 6' 0" | 200 lbs | - |
| Srivastav, Abhipala | CF | Syracuse Squirrel Monkeys | 28 | 05/08/2017 | Rohtak | IND | Right | Right | 6' 3" | 200 lbs | - |
| Stafford, Zach | 3B | Ellenburg Fighting Dachsunds | 25 | 01/20/2020 | Buffalo | USA | Right | Right | 6' 3" | 195 lbs | - |
| Stanley, Carter | 1B | Kansas Rainbeaus | 25 | 11/16/2020 | Tamalpais-Homestead Valley | USA | Left | Left | 6' 6" | 245 lbs | - |
| Stanley, Forest | SP | Syracuse Squirrel Monkeys | 35 | 06/27/2010 | Bartlesville | USA | Switch | Right | 6' 3" | 225 lbs | $1,600,000 |
| Stevens, John | RP | Hialeah Dodos | 26 | 04/15/2019 | Porcupine | CAN | Right | Right | 6' 0" | 200 lbs | $280,000 |
| Stone, David | SS | Free Agent | 31 | 10/16/2014 | Chicago | USA | Right | Right | 6' 2" | 195 lbs | - |
| Strong, Tim | RP | Sacramento Redlegs | 22 | 02/16/2023 | Quincy | USA | Left | Left | 6' 4" | 200 lbs | - |
| Studdard, Antoine | 2B | Milton Dogfish Head | 31 | 12/17/2014 | Newark | USA | Left | Right | 6' 0" | 200 lbs | $280,000 |
| Summers, Dave | LF | Syracuse Squirrel Monkeys | 29 | 08/18/2016 | Dearborn Heights | USA | Left | Left | 6' 0" | 195 lbs | $280,000 |
