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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| San Pedro, Tony | C | Austin Black Mambas | 23 | 04/29/2021 | San Pedro Sula | HON | Left | Right | 6' 0" | 200 lbs | - |
| Sánchez, Tomás | 1B | Sioux Falls Red Pandas | 25 | 06/28/2019 | Santiago de Cuba | CUB | Switch | Left | 6' 0" | 200 lbs | $280,000 |
| Sanders, Dan | SP | Austin Black Mambas | 26 | 09/09/2018 | Dunstable | USA | Right | Right | 6' 1" | 200 lbs | - |
| Sandison, Len | CF | Salt Lake City Buzz | 22 | 10/13/2022 | Marion | USA | Left | Left | 6' 0" | 190 lbs | - |
| Santiago, Rafael | RP | Austin Black Mambas | 31 | 10/27/2013 | Yara | CUB | Right | Right | 5' 11" | 195 lbs | - |
| Santos, José | RP | Port Huron Blitzkrieg | 30 | 07/13/2014 | Los Angeles | USA | Left | Left | 6' 1" | 215 lbs | - |
| Sapinoso, Juan | RF | Milton Dogfish Head | 22 | 05/27/2022 | Puerto Plata | DOM | Left | Left | 6' 1" | 190 lbs | - |
| Sarkar, Syed | 1B | Port Huron Blitzkrieg | 34 | 02/20/2010 | Dinajpur | BAN | Right | Right | 6' 3" | 245 lbs | - |
| Sassetti, Timoteo | RP | Sioux Falls Red Pandas | 33 | 12/30/2011 | Caltanissetta | ITA | Right | Right | 5' 10" | 180 lbs | - |
| Sawyer, Davis | SP | Nolensville Knights | 33 | 03/21/2011 | Shawnee | USA | Right | Right | 6' 5" | 240 lbs | $6,530,000 |
| Schmidt, Kelvin | 1B | Sioux Falls Red Pandas | 25 | 08/06/2019 | Cul De Sac | SIM | Left | Right | 6' 1" | 205 lbs | - |
| Schweitzer, Laurent | RP | Port Huron Blitzkrieg | 24 | 09/16/2020 | Toronto | CAN | Left | Right | 6' 3" | 215 lbs | - |
| Scott, Mike | 2B | Port Huron Blitzkrieg | 25 | 12/29/2019 | San Antonio | USA | Left | Right | 6' 0" | 195 lbs | - |
| Security, Maxwell | RP | Calgary Lynx | 26 | 10/06/2018 | Dallas | USA | Right | Right | 6' 2" | 210 lbs | - |
| Seymour, Dan | SP | Santa Barbara Golden Cranes | 24 | 03/04/2020 | Canton | USA | Right | Right | 6' 2" | 195 lbs | $440,000 |
| Shen, Qi-zhen | 1B | Florida Men | 25 | 07/29/2019 | Kangshan | TPE | Left | Right | 6' 1" | 205 lbs | - |
| Shepherd, Alan | SS | Baton Rouge Brass | 24 | 07/06/2020 | Arlington | USA | Right | Right | 6' 3" | 200 lbs | - |
| Silva, Ángel | RP | Baton Rouge Brass | 31 | 01/11/2013 | Santo Domingo | DOM | Left | Left | 5' 10" | 180 lbs | $280,000 |
| Silva, Mario | RP | Calgary Lynx | 26 | 07/10/2018 | Sparta | USA | Right | Right | 6' 1" | 195 lbs | - |
| Sin, Man-su | LF | Austin Black Mambas | 26 | 03/13/2018 | Sunchon | PRK | Left | Left | 6' 2" | 200 lbs | - |
| Sorondo, Julián | 2B | Santa Barbara Golden Cranes | 20 | 12/05/2024 | Ciudad Bolívar | VEN | Left | Right | 6' 2" | 175 lbs | - |
| Soto, Bartolo | RF | Free Agent | 35 | 09/07/2009 | Puerto Plata | DOM | Left | Left | 6' 2" | 245 lbs | - |
| Spirk, Kliment | RP | Port Huron Blitzkrieg | 33 | 04/19/2011 | Ceska Kamenice | CZE | Right | Right | 6' 1" | 195 lbs | - |
| Steele, Morton | RP | Sioux Falls Red Pandas | 34 | 09/04/2010 | Carmichael | USA | Left | Right | 6' 4" | 245 lbs | - |
| Stephens, Phil | RP | Port Huron Blitzkrieg | 25 | 01/05/2019 | Whitney | USA | Right | Left | 5' 10" | 185 lbs | - |
| Stevens, Marvin | RP | Vermont Lake Monsters | 26 | 11/25/2018 | Maynardville | USA | Right | Right | 6' 5" | 235 lbs | - |
| Stevens, William | RP | Sunset District Fog | 21 | 05/17/2023 | Bell Gardens | USA | Left | Left | 6' 4" | 200 lbs | - |
| Stirzacre, Everton | RP | Salt Lake City Buzz | 23 | 06/14/2021 | Somersham | ENG | Left | Left | 6' 4" | 205 lbs | - |
| Stone, David | SS | Salt Lake City Buzz | 30 | 10/16/2014 | Chicago | USA | Right | Right | 6' 2" | 190 lbs | - |
| Sugahara, Matsudaira | SS | Florida Men | 29 | 08/10/2015 | Hachioji | JPN | Right | Right | 6' 0" | 185 lbs | $280,000 |
| Swetnam, Edward | RP | Florida Men | 23 | 06/22/2021 | Charlotte Amalie | VIR | Right | Right | 6' 2" | 190 lbs | - |
