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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sánchez, Arturo | RP | Put-In-Bay Commodores | 22 | 10/27/2022 | Chilibre | PAN | Right | Right | 6' 2" | 185 lbs | - |
| Sanders, Chris | C | Huntington Hermit Crabs | 22 | 07/17/2022 | Taylor | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sandoval, Fernando | RP | Put-In-Bay Commodores | 22 | 03/12/2022 | Turrialba | CRC | Right | Right | 6' 2" | 180 lbs | - |
| Sasaki, Soh | RF | Smoky Mountain Hobeaus | 22 | 06/11/2022 | Matsuyama | JPN | Right | Left | 6' 2" | 200 lbs | - |
| Sato, Tadasu | 3B | Smoky Mountain Hobeaus | 22 | 08/26/2022 | Tokushima | JPN | Right | Right | 6' 0" | 190 lbs | - |
| Shachi, Apaghana | RP | Grim Reapers | 20 | 03/18/2024 | Kanpur | IND | Right | Right | 6' 6" | 210 lbs | - |
| Sharif, Ghidewon | C | Laredo Hawks | 19 | 03/01/2025 | Brakpan | RSA | Right | Right | 6' 0" | 190 lbs | - |
| Sharp, John | CF | Lake Erie Arryns | 22 | 05/17/2022 | McPherson | USA | Right | Right | 6' 2" | 195 lbs | - |
| Sigurdson, Leland | CF | Grim Reapers | 21 | 02/01/2023 | Phoenix | USA | Right | Right | 5' 11" | 170 lbs | - |
| Singh, Soshal Distan | 2B | Grim Reapers | 21 | 06/27/2023 | Bangalore | IND | Right | Right | 6' 0" | 180 lbs | - |
| Smith, Horace | SP | Athletic Club KC U-24 | 20 | 01/09/2024 | Los Angeles | USA | Right | Right | 6' 1" | 180 lbs | - |
| Soto, Emílio | CF | Laredo Hawks | 20 | 10/22/2024 | Cajamarca | PER | Right | Right | 6' 0" | 180 lbs | - |
| Spronck, Chiel | RF | Huntington Hermit Crabs | 20 | 03/18/2024 | Willemstad | CUR | Right | Right | 6' 2" | 175 lbs | - |
| Stanworth, Harley | 1B | Athletic Club KC U-24 | 21 | 06/24/2023 | Maroon Town | JAM | Switch | Right | 6' 2" | 205 lbs | - |
| Stevens, Claude | SP | Kent Comets | 23 | 07/04/2021 | Kansas City | USA | Left | Right | 6' 7" | 235 lbs | - |
| Stevens, Jason | RP | Smoky Mountain Hobeaus | 22 | 09/29/2022 | Lake Ronkonkoma | USA | Right | Right | 6' 1" | 185 lbs | - |
| Stewart, Roy | SS | Grim Reapers | 20 | 01/22/2024 | Hamilton | USA | Right | Right | 6' 4" | 185 lbs | - |
| Stroud, Tim | SP | Lake Erie Arryns | 24 | 09/23/2020 | Garden Grove | USA | Right | Right | 6' 7" | 220 lbs | - |
| Sugiyama, Yoshihide | SP | Huntington Hermit Crabs | 23 | 09/15/2021 | Toyota | JPN | Right | Right | 5' 10" | 195 lbs | - |
| Suzuki, Shusui | RP | Grim Reapers | 21 | 07/07/2023 | Hiratsuka | JPN | Right | Right | 6' 8" | 215 lbs | - |
