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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sahar, Anathapinda | SP | Chesapeake Cangrejos Fantasmas | 22 | 04/06/2021 | Shohratgarh | IND | Right | Left | 6' 2" | 185 lbs | - |
| Salas, José | 2B | Nuevo Mexico Mariachis | 24 | 06/30/2019 | Dajabón | DOM | Right | Right | 6' 0" | 190 lbs | - |
| Salas, Lúcio | SP | Providence Pilgrims | 27 | 01/02/2016 | Caracas | VEN | Right | Right | 6' 2" | 200 lbs | - |
| Santos, Pedro | RF | Nuevo Mexico Mariachis | 25 | 07/03/2018 | Ft. Worth | USA | Right | Right | 6' 2" | 195 lbs | - |
| Saromi, Sekien | CL | Nuevo Mexico Mariachis | 23 | 07/20/2020 | Narashino | JPN | Right | Right | 6' 3" | 195 lbs | - |
| Sawyer, John | RP | Westwood Sixshooters | 26 | 06/10/2017 | Lehi | USA | Left | Left | 6' 2" | 195 lbs | - |
| Schaller, Ari | CL | Northville Eclipse | 22 | 04/20/2021 | Eggendorf | AUT | Right | Right | 6' 1" | 185 lbs | - |
| Seawright, John | SP | Northville Eclipse | 28 | 06/01/2015 | Kennebunk | USA | Switch | Right | 5' 11" | 195 lbs | - |
| Semprún, Carlos | SP | Chesapeake Cangrejos Fantasmas | 23 | 03/04/2020 | Santo Domingo | DOM | Left | Left | 6' 4" | 195 lbs | - |
| Sewell, Jake | RP | Olympia Ogres | 23 | 12/10/2020 | El Paso | USA | Left | Left | 6' 0" | 185 lbs | - |
| Shades, Sanford | SP | Northville Eclipse | 27 | 09/21/2016 | Inver Grove Heights | USA | Right | Right | 6' 2" | 210 lbs | - |
| Shelley, Erwin | SP | Westwood Sixshooters | 25 | 08/25/2018 | Montreal | CAN | Right | Right | 6' 3" | 205 lbs | - |
| Shu, Huang-di | 3B | St. Petersburg Thunder | 24 | 10/30/2019 | Tachi | TPE | Switch | Right | 5' 10" | 185 lbs | - |
| Siddall, John | 3B | Westwood Sixshooters | 27 | 05/22/2016 | Brampton | CAN | Right | Right | 6' 4" | 215 lbs | - |
| Sierra, Juan | 2B | Westwood Sixshooters | 26 | 04/20/2017 | Rolling Hills Estates | USA | Right | Right | 6' 4" | 215 lbs | - |
| Sims, Bob | 3B | Ithaca Fighting Imps | 26 | 06/02/2017 | Hamilton | USA | Right | Right | 6' 1" | 195 lbs | - |
| Sinclair, Jacob | SP | Providence Pilgrims | 23 | 09/26/2020 | Louisville | USA | Switch | Right | 6' 2" | 190 lbs | - |
| Situ, Zee-loo | 2B | Mercer Island Screaming Eagles | 22 | 06/25/2021 | Shijiazhuang | CHN | Right | Right | 6' 1" | 185 lbs | - |
| Smiley, Ray | SP | Chesapeake Cangrejos Fantasmas | 23 | 12/11/2020 | Youngstown | USA | Right | Left | 6' 2" | 200 lbs | - |
| Smith, Dan | RP | Mercer Island Screaming Eagles | 22 | 02/21/2021 | Somers Point | USA | Right | Right | 6' 0" | 185 lbs | - |
| Soriano, José | C | Chesapeake Cangrejos Fantasmas | 24 | 07/31/2019 | Juigalpa | NCA | Right | Right | 6' 0" | 195 lbs | - |
| Sparks, John | SP | Northville Eclipse | 27 | 01/29/2016 | McHenry | USA | Right | Right | 6' 2" | 190 lbs | - |
| Sprinkle, Andrew | 3B | Ft. Polk South Thunder Hawks | 23 | 04/14/2020 | New Orleans | USA | Right | Right | 6' 1" | 190 lbs | - |
| St. John, Daniel | RP | Chesapeake Cangrejos Fantasmas | 23 | 09/08/2020 | Concord | USA | Switch | Right | 6' 1" | 185 lbs | - |
| St. John, John | RP | Providence Pilgrims | 27 | 04/09/2016 | Scott | USA | Switch | Right | 6' 0" | 195 lbs | - |
| Stark, Paul | 2B | Olympia Ogres | 24 | 01/07/2019 | Schaumburg | USA | Right | Right | 6' 3" | 180 lbs | - |
| Stickells, Bill | RF | St. Petersburg Thunder | 21 | 04/06/2022 | Wayne | USA | Left | Left | 6' 4" | 195 lbs | - |
| Subramanya, Cakaraka | RP | Nuevo Mexico Mariachis | 26 | 01/13/2017 | Koyampattur | IND | Switch | Right | 6' 5" | 190 lbs | - |
| Suto, Teika | SP | Providence Pilgrims | 28 | 05/25/2015 | Kawasaki | JPN | Right | Left | 6' 4" | 200 lbs | - |
| Swanson, Doug | RP | Olympia Ogres | 23 | 06/01/2020 | Harrisburg | USA | Left | Left | 6' 1" | 200 lbs | - |
