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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sa, Hyeon-uk | RP | Forest City Warriors | 27 | 08/12/2016 | Sangju | KOR | Left | Right | 6' 3" | 195 lbs | - |
| Sabadodíaz, Wilson | RF | Baton Rouge Brass | 29 | 12/13/2014 | Telluride | USA | Left | Left | 6' 1" | 220 lbs | $480,000 |
| Sacasas, Ernesto | C | Pawnee ParksNRec | 22 | 10/05/2021 | Alotenango | GUA | Switch | Right | 6' 0" | 195 lbs | - |
| Sainz, Eduardo | C | Pawnee ParksNRec | 23 | 11/06/2020 | Santa Ana | CRC | Right | Right | 6' 0" | 185 lbs | - |
| Salazar, José | SP | Pennsauken Flyers | 27 | 06/05/2016 | Las Tunas | CUB | Right | Right | 6' 1" | 200 lbs | - |
| San Martín, Sergio | SS | Hialeah Dodos | 31 | 09/25/2012 | Bedford | USA | Right | Right | 5' 9" | 195 lbs | - |
| Sánchez, Ángel | C | Pawnee ParksNRec | 22 | 11/04/2021 | Bayamón | PUR | Right | Right | 6' 1" | 205 lbs | - |
| Sánchez, Ramón | RP | Forest City Warriors | 26 | 03/09/2017 | Lake Los Angeles | USA | Right | Left | 5' 10" | 170 lbs | - |
| Sarkies, Rod | 1B | Baton Rouge Brass | 26 | 06/27/2017 | Canberra | AUS | Right | Right | 6' 3" | 220 lbs | $280,000 |
| Sastre, Luis | SP | Syracuse Squirrel Monkeys | 25 | 06/03/2018 | La Mata | DOM | Right | Right | 6' 5" | 210 lbs | $280,000 |
| Scanlan, Oakland | RP | Forest City Warriors | 29 | 06/08/2014 | Salem | USA | Right | Right | 6' 8" | 250 lbs | - |
| Scott, Jerry | CF | Syracuse Squirrel Monkeys | 25 | 01/25/2018 | Elizabethtown | USA | Right | Right | 6' 2" | 205 lbs | - |
| Shadix, Byron | RF | Pennsauken Flyers | 25 | 02/08/2018 | Mesa | USA | Right | Right | 6' 3" | 205 lbs | - |
| Shen, Qi-zhen | 1B | Florida Men | 24 | 07/29/2019 | Kangshan | TPE | Left | Right | 6' 1" | 210 lbs | - |
| Shepherd, Alan | SS | Baton Rouge Brass | 23 | 07/06/2020 | Arlington | USA | Right | Right | 6' 3" | 195 lbs | - |
| Silva, David | SP | Baton Rouge Brass | 29 | 03/19/2014 | Las Palmas | ESP | Right | Right | 6' 2" | 200 lbs | - |
| Smith, Robert | RP | Syracuse Squirrel Monkeys | 30 | 04/02/2013 | New York | USA | Right | Right | 5' 11" | 195 lbs | - |
| Snodgrass, Roger | 3B | Free Agent | 30 | 10/27/2013 | New York | USA | Right | Right | 6' 4" | 250 lbs | - |
| Soriano, José | CF | Baton Rouge Brass | 29 | 05/11/2014 | Palos Heights | USA | Left | Left | 6' 1" | 205 lbs | $280,000 |
| Sparks, Clyde | RP | Hialeah Dodos | 27 | 05/07/2016 | Casper | USA | Right | Right | 6' 0" | 190 lbs | - |
| Srivastav, Abhipala | CF | Syracuse Squirrel Monkeys | 26 | 05/08/2017 | Rohtak | IND | Right | Right | 6' 3" | 195 lbs | - |
| St. Brown, Amon-Ra | 1B | Baton Rouge Brass | 35 | 08/28/2008 | New York | USA | Right | Right | 5' 10" | 215 lbs | $280,000 |
| Stanley, Carter | 1B | Kansas Rainbeaus | 23 | 11/16/2020 | Tamalpais-Homestead Valley | USA | Left | Left | 6' 6" | 245 lbs | - |
| Stanton, Bill | RF | Free Agent | 29 | 10/10/2014 | Little Canada | USA | Left | Left | 6' 5" | 235 lbs | - |
| Stengel, Greg | SP | Pennsauken Flyers | 23 | 11/13/2020 | Bailey's Crossroads | USA | Left | Left | 6' 0" | 180 lbs | - |
| Stevens, John | RP | Hialeah Dodos | 24 | 04/15/2019 | Porcupine | CAN | Right | Right | 6' 0" | 200 lbs | $280,000 |
| Stokes, Lawrence | 3B | Forest City Warriors | 32 | 04/12/2011 | Savannah | USA | Right | Right | 6' 4" | 225 lbs | $280,000 |
| Sugahara, Matsudaira | SS | Florida Men | 28 | 08/10/2015 | Hachioji | JPN | Right | Right | 6' 0" | 190 lbs | $280,000 |
| Suisha, Yasunobu | SP | Monongahela Monsters | 25 | 03/24/2018 | Kimitsu | JPN | Left | Left | 6' 6" | 215 lbs | - |
| Summers, Dave | RF | Baton Rouge Brass | 27 | 08/18/2016 | Dearborn Heights | USA | Left | Left | 6' 0" | 195 lbs | $280,000 |
| Swetnam, Edward | RP | Florida Men | 22 | 06/22/2021 | Charlotte Amalie | VIR | Right | Right | 6' 2" | 190 lbs | - |
