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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salinas, Marcos | RP | Sunset District Fog | 27 | 12/01/2016 | Xaloztoc | MEX | Right | Right | 6' 1" | 190 lbs | - |
| Sanders, Dan | SP | Austin Black Mambas | 25 | 09/09/2018 | Dunstable | USA | Right | Right | 6' 1" | 200 lbs | - |
| Santiago, Rafael | RP | Austin Black Mambas | 30 | 10/27/2013 | Yara | CUB | Right | Right | 5' 11" | 195 lbs | - |
| Santos, José | RP | Port Huron Blitzkrieg | 29 | 07/13/2014 | Los Angeles | USA | Left | Left | 6' 1" | 210 lbs | - |
| Santos, Pablo | SS | Sioux Falls Red Pandas | 27 | 02/15/2016 | San Vicente | SLV | Right | Right | 6' 1" | 200 lbs | - |
| Sanu, Shiki | 3B | Calgary Lynx | 36 | 05/29/2007 | Sapporo | JPN | Switch | Right | 6' 1" | 220 lbs | $2,600,000 |
| Sapinoso, Juan | RF | Milton Dogfish Head | 21 | 05/27/2022 | Puerto Plata | DOM | Left | Left | 6' 1" | 195 lbs | - |
| Sarkar, Syed | 1B | Port Huron Blitzkrieg | 33 | 02/20/2010 | Dinajpur | BAN | Right | Right | 6' 3" | 245 lbs | - |
| Sawyer, Davis | CL | Nolensville Knights | 32 | 03/21/2011 | Shawnee | USA | Right | Right | 6' 5" | 240 lbs | $6,530,000 |
| Scott, Jimmy | C | Free Agent | 33 | 03/15/2010 | Bronx | USA | Right | Right | 6' 5" | 230 lbs | - |
| Scott, Morton | 2B | Athletic Club KC Reserves | 24 | 01/29/2019 | Paris | USA | Right | Right | 6' 0" | 190 lbs | - |
| Seals, Glenn | 3B | Salt Lake City Buzz | 24 | 07/20/2019 | Coral Springs | USA | Right | Right | 6' 0" | 185 lbs | - |
| Security, Maxwell | RP | Calgary Lynx | 25 | 10/06/2018 | Dallas | USA | Right | Right | 6' 2" | 210 lbs | - |
| Sellers, Cameron | SP | Ellenburg Fighting Dachsunds | 27 | 07/22/2016 | Pasco | USA | Right | Right | 6' 1" | 215 lbs | - |
| Serrano, Lonnie | 2B | Calgary Lynx | 23 | 05/31/2020 | Rancho Cucamonga | USA | Right | Right | 6' 2" | 205 lbs | - |
| Shannon, Robert | 1B | Vermont Lake Monsters | 23 | 07/08/2020 | Paradise | USA | Left | Right | 6' 0" | 200 lbs | $280,000 |
| Shepard, Colton | C | Ellenburg Fighting Dachsunds | 23 | 02/01/2020 | Bensenville | USA | Right | Right | 6' 3" | 215 lbs | - |
| Shiu, Quan | RP | Free Agent | 34 | 12/27/2009 | Taipei | TPE | Left | Left | 6' 5" | 210 lbs | - |
| Silva, Mario | SP | Calgary Lynx | 25 | 07/10/2018 | Sparta | USA | Right | Right | 6' 1" | 195 lbs | - |
| Simon, Carlos | SP | Nolensville Knights | 31 | 11/13/2012 | Fresno | USA | Right | Right | 6' 3" | 210 lbs | $280,000 |
| Sin, Man-su | LF | Austin Black Mambas | 25 | 03/13/2018 | Sunchon | PRK | Left | Left | 6' 2" | 195 lbs | - |
| Smith, Tim | SP | Salt Lake City Buzz | 26 | 03/17/2017 | Hiram | USA | Right | Right | 6' 0" | 195 lbs | - |
| Speranza, Paolo | RP | Free Agent | 27 | 10/30/2016 | Valencia | VEN | Switch | Left | 5' 10" | 175 lbs | - |
| Spirk, Kliment | RP | Port Huron Blitzkrieg | 32 | 04/19/2011 | Ceska Kamenice | CZE | Right | Right | 6' 1" | 195 lbs | - |
| Starr, Jamie | 3B | Santa Barbara Golden Cranes | 26 | 10/26/2017 | Carolina | PUR | Left | Right | 6' 3" | 215 lbs | $280,000 |
| Steele, Willie | CL | Santa Barbara Golden Cranes | 23 | 06/09/2020 | Denver | USA | Left | Right | 6' 0" | 185 lbs | - |
| Stevens, Marvin | RP | Vermont Lake Monsters | 25 | 11/25/2018 | Maynardville | USA | Right | Right | 6' 5" | 230 lbs | - |
| Studdard, Antoine | 2B | Milton Dogfish Head | 29 | 12/17/2014 | Newark | USA | Left | Right | 6' 0" | 200 lbs | $280,000 |
| Stuterberg, Harry | SP | Santa Barbara Golden Cranes | 33 | 10/06/2010 | New York | USA | Right | Right | 6' 2" | 210 lbs | - |
