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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saksansin, Poom | SP | Richland Rails | 22 | 10/07/2020 | Chiang Khong | THA | Right | Right | 6' 3" | 190 lbs | - |
| Salas, Bill | SP | Lake Minnetonka Love Boats | 24 | 06/23/2018 | Santa Ana | USA | Left | Left | 6' 3" | 215 lbs | - |
| Salazar, José | CL | Bethesda Atoms | 26 | 06/05/2016 | Las Tunas | CUB | Right | Right | 6' 1" | 195 lbs | - |
| Salinas, Juan | RP | Asheville Highlanders | 25 | 08/10/2017 | Aibonito | PUR | Left | Right | 6' 1" | 190 lbs | - |
| Sanders, Chris | RP | Bethesda Atoms | 28 | 11/05/2014 | Security-Widefield | USA | Right | Right | 6' 1" | 200 lbs | - |
| Sanders, Paul | SS | Minnesota Loons | 24 | 07/27/2018 | Hollandale | USA | Right | Right | 6' 2" | 195 lbs | - |
| Santana, Rodrigo | 3B | Squirrel Hill Pierogis | 25 | 12/28/2017 | San Diego | USA | Switch | Right | 5' 11" | 195 lbs | - |
| Santana, Rubén | SP | Asheville Highlanders | 23 | 06/03/2019 | Hartshorne | USA | Switch | Right | 6' 4" | 205 lbs | - |
| Santos, Pablo | SS | Lake Minnetonka Love Boats | 26 | 02/15/2016 | San Vicente | SLV | Right | Right | 6' 1" | 200 lbs | - |
| Sapinoso, Juan | RF | Asheville Highlanders | 20 | 05/27/2022 | Puerto Plata | DOM | Left | Left | 6' 1" | 185 lbs | - |
| Saunders, Carl | LF | Marquette Miners | 26 | 05/24/2016 | Gresham | USA | Switch | Right | 6' 1" | 205 lbs | - |
| Scott, Elijah | 1B | Barton Springs Blues | 22 | 04/14/2020 | Kennesaw | USA | Left | Left | 6' 2" | 200 lbs | - |
| Seals, Glenn | 3B | Richland Rails | 23 | 07/20/2019 | Coral Springs | USA | Right | Right | 6' 0" | 185 lbs | - |
| Sellers, Cameron | SP | Marquette Miners | 26 | 07/22/2016 | Pasco | USA | Right | Right | 6' 1" | 210 lbs | - |
| Shallcross, Nathan | CF | Irving Blue Sox | 22 | 04/17/2020 | New York | USA | Left | Left | 6' 1" | 180 lbs | - |
| Shepard, Colton | C | Marquette Miners | 22 | 02/01/2020 | Bensenville | USA | Right | Right | 6' 3" | 210 lbs | - |
| Shreeve, Tim | RP | Billings Polar Bears | 25 | 08/24/2017 | Fresno | USA | Right | Right | 6' 0" | 205 lbs | - |
| Skinner, Jason | RP | Asheville Highlanders | 25 | 09/02/2017 | Monongahela | USA | Right | Right | 5' 10" | 180 lbs | - |
| Small, Leslie | CF | Marquette Miners | 28 | 09/23/2014 | Staten Island | USA | Left | Right | 6' 1" | 215 lbs | - |
| Smith, Joe | CF | Barton Springs Blues | 28 | 03/20/2014 | Detroit | USA | Right | Right | 6' 3" | 225 lbs | - |
| Smith, Josh | RP | Bethesda Atoms | 22 | 02/16/2020 | Villas | USA | Right | Left | 6' 2" | 195 lbs | - |
| Steele, Willie | CL | Lake Minnetonka Love Boats | 22 | 06/09/2020 | Denver | USA | Left | Right | 6' 0" | 185 lbs | - |
| Stengel, Greg | SP | Bethesda Atoms | 22 | 11/13/2020 | Bailey's Crossroads | USA | Left | Left | 6' 0" | 180 lbs | - |
| Stevens, Ron | RP | Billings Polar Bears | 24 | 10/22/2018 | Garner | USA | Left | Right | 6' 0" | 205 lbs | - |
| Stidston, Fergus | SS | Barton Springs Blues | 28 | 02/16/2014 | Oranjestad | ARU | Switch | Right | 6' 1" | 190 lbs | - |
| Swetnam, Edward | RP | Squirrel Hill Pierogis | 21 | 06/22/2021 | Charlotte Amalie | VIR | Right | Right | 6' 2" | 190 lbs | - |
