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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saavedra, Pablo | 3B | Vermont Lake Monsters | 25 | 02/16/2017 | Santo Domingo | DOM | Right | Right | 6' 2" | 205 lbs | - |
| Sacasas, Ernesto | C | Pawnee ParksNRec | 21 | 10/05/2021 | Alotenango | GUA | Switch | Right | 6' 0" | 185 lbs | - |
| San Martín, Sergio | SS | Hialeah Dodos | 30 | 09/25/2012 | Bedford | USA | Right | Right | 5' 9" | 190 lbs | - |
| Sandoval, Fernando | LF | Free Agent | 27 | 03/31/2015 | Soacha | COL | Left | Left | 6' 4" | 225 lbs | - |
| Santos, Juan | RP | Vermont Lake Monsters | 25 | 01/28/2017 | Santo Domingo | DOM | Right | Right | 6' 3" | 195 lbs | - |
| Sastre, Luis | SP | Scranton Supernovas | 24 | 06/03/2018 | La Mata | DOM | Right | Right | 6' 5" | 210 lbs | $280,000 |
| Scott, Jerry | CF | Scranton Supernovas | 24 | 01/25/2018 | Elizabethtown | USA | Right | Right | 6' 2" | 205 lbs | - |
| Searle, Stu | CL | Hamilton Coyotes | 23 | 09/09/2019 | Ottawa | CAN | Left | Right | 6' 3" | 210 lbs | - |
| Sherman, Phil | C | Vermont Lake Monsters | 36 | 10/09/2006 | Claverack-Red Mills | USA | Right | Right | 6' 0" | 220 lbs | $280,000 |
| Silva, Miguel | C | Memphis Redbirds | 27 | 09/08/2015 | Manicaragua | CUB | Right | Right | 6' 1" | 215 lbs | - |
| Smith, Robert | RP | Scranton Supernovas | 29 | 04/02/2013 | New York | USA | Right | Right | 5' 11" | 195 lbs | - |
| Soto, César | SP | Hialeah Dodos | 30 | 02/26/2012 | Maracaibo | VEN | Right | Right | 6' 0" | 190 lbs | - |
| Soto, Luis | RP | Hamilton Coyotes | 30 | 09/08/2012 | Cornwells Heights-Eddington | USA | Left | Left | 6' 2" | 210 lbs | - |
| Spirk, Kliment | RP | Port Huron Blitzkrieg | 31 | 04/19/2011 | Ceska Kamenice | CZE | Right | Right | 6' 1" | 195 lbs | - |
| Stanley, Carter | 1B | Memphis Redbirds | 22 | 11/16/2020 | Tamalpais-Homestead Valley | USA | Left | Left | 6' 6" | 235 lbs | - |
| Stevens, John | RP | Hialeah Dodos | 23 | 04/15/2019 | Porcupine | CAN | Right | Right | 6' 0" | 195 lbs | $280,000 |
| Stokes, Dan | RP | Memphis Redbirds | 24 | 04/19/2018 | Portland | USA | Left | Left | 6' 3" | 210 lbs | $420,000 |
| Strachota, Todd | LF | Vermont Lake Monsters | 26 | 11/03/2016 | St. Paul Park | USA | Left | Left | 6' 3" | 220 lbs | - |
| Strozier, Larry | RP | Vermont Lake Monsters | 34 | 03/02/2008 | Bayonet Point | USA | Left | Right | 6' 0" | 200 lbs | - |
| Sugahara, Matsudaira | SS | Florida Men | 27 | 08/10/2015 | Hachioji | JPN | Right | Right | 6' 0" | 190 lbs | $280,000 |
