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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sahar, Anathapinda | SP | Galesburg Guzzlers | 21 | 04/06/2021 | Shohratgarh | IND | Right | Left | 6' 2" | 180 lbs | - |
| Saito, Sen | RP | South Beach Blaze | 20 | 03/11/2022 | Hachioji | JPN | Left | Left | 6' 1" | 175 lbs | - |
| Salas, Juan | SP | Eugene Vandals | 20 | 03/10/2022 | San Francisco de Macorís | DOM | Right | Right | 6' 4" | 190 lbs | - |
| Salinas, Valerio | C | Lake Erie Arryns | 22 | 01/18/2020 | Caracas | VEN | Right | Right | 6' 3" | 205 lbs | - |
| Sánchez, José | 1B | Kent Comets | 25 | 10/14/2017 | Nicoya | CRC | Right | Right | 6' 2" | 195 lbs | - |
| Saromi, Sekien | CL | Chicago Tula | 22 | 07/20/2020 | Narashino | JPN | Right | Right | 6' 3" | 195 lbs | - |
| Schaller, Ari | CL | Caldwell Chiefs | 21 | 04/20/2021 | Eggendorf | AUT | Right | Right | 6' 1" | 185 lbs | - |
| Schultz, Johnny | RF | Eugene Vandals | 21 | 12/26/2021 | New York | USA | Right | Left | 6' 4" | 195 lbs | - |
| Scott, Dave | SS | South Beach Blaze | 22 | 10/31/2020 | New York | USA | Switch | Right | 6' 0" | 170 lbs | - |
| Sedlaczek, Vratislav | SP | Lake Erie Arryns | 24 | 11/01/2018 | Svitavy | CZE | Switch | Right | 6' 6" | 205 lbs | - |
| Semprún, Ramón | 2B | Rocky Mountain Vibes | 23 | 07/29/2019 | Catia La Mar | VEN | Right | Right | 5' 11" | 185 lbs | - |
| Serrano, Adrián | C | Eugene Vandals | 20 | 04/07/2022 | San Pedro de Macorís | DOM | Right | Right | 6' 0" | 190 lbs | - |
| Sewell, Jake | RP | Eugene Vandals | 22 | 12/10/2020 | El Paso | USA | Left | Left | 6' 0" | 185 lbs | - |
| Shelley, Erwin | SP | Rocky Mountain Vibes | 24 | 08/25/2018 | Montreal | CAN | Right | Right | 6' 3" | 205 lbs | - |
| Shepherd, Alan | SS | Cut Off Crawdads | 22 | 07/06/2020 | Arlington | USA | Right | Right | 6' 3" | 190 lbs | - |
| Shimizu, Takayuki | SP | Rocky Mountain Vibes | 21 | 07/22/2021 | Tokyo | JPN | Left | Left | 6' 1" | 175 lbs | - |
| Shive, Fredrick | SP | Kent Comets | 24 | 09/19/2018 | North Ogden | USA | Right | Right | 6' 1" | 195 lbs | - |
| Simmons, Lance | SP | Myrtle Beach Seahawks | 23 | 09/20/2019 | Sunnyvale | USA | Left | Left | 6' 1" | 185 lbs | - |
| Simpson, John | 3B | Myrtle Beach Seahawks | 21 | 11/02/2021 | Memphis | USA | Right | Right | 5' 11" | 170 lbs | - |
| Smiley, Ray | SP | Galesburg Guzzlers | 22 | 12/11/2020 | Youngstown | USA | Right | Left | 6' 2" | 190 lbs | - |
| Smith, Dan | RP | South Beach Blaze | 21 | 02/21/2021 | Somers Point | USA | Right | Right | 6' 0" | 180 lbs | - |
| Smith, Joe | 3B | Chicago Tula | 22 | 10/26/2020 | Fountain Hills | USA | Right | Right | 6' 1" | 190 lbs | - |
| Solano, Paco | RP | Lake Erie Arryns | 23 | 01/28/2019 | San Juan | PUR | Right | Left | 6' 1" | 190 lbs | - |
| Sousa, Jim | SP | Rocky Mountain Vibes | 24 | 04/07/2018 | Bordentown | USA | Right | Right | 6' 1" | 180 lbs | - |
| Sprinkle, Andrew | 3B | Myrtle Beach Seahawks | 22 | 04/14/2020 | New Orleans | USA | Right | Right | 6' 1" | 190 lbs | - |
| St. John, Daniel | RP | Galesburg Guzzlers | 22 | 09/08/2020 | Concord | USA | Switch | Right | 6' 1" | 185 lbs | - |
| Stephens, José | RP | Chicago Tula | 20 | 06/25/2022 | Staten Island | USA | Right | Right | 5' 9" | 165 lbs | - |
| Stone, Herman | RP | Chicago Tula | 23 | 10/30/2019 | Upland | USA | Right | Left | 6' 2" | 210 lbs | - |
| Sugimoto, Kuniyuki | SP | Cut Off Crawdads | 22 | 02/15/2020 | Toyonaka | JPN | Right | Right | 6' 3" | 195 lbs | - |
| Sun, Ching | 3B | Galesburg Guzzlers | 21 | 04/07/2021 | Taipei | TPE | Right | Right | 5' 10" | 175 lbs | - |
| Suzuarregui, Ramón | SS | Kent Comets | 20 | 01/25/2022 | Managua | NCA | Right | Right | 5' 11" | 165 lbs | - |
| Swanson, Doug | RP | Eugene Vandals | 22 | 06/01/2020 | Harrisburg | USA | Left | Left | 6' 1" | 195 lbs | - |
