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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sainz, Eduardo | C | Tacoma Fur Traders | 21 | 11/06/2020 | Santa Ana | CRC | Right | Right | 6' 0" | 190 lbs | - |
| San Martín, Sergio | SS | Virginia Beach Whales | 29 | 09/25/2012 | Bedford | USA | Right | Right | 5' 9" | 195 lbs | - |
| Sánchez, Adrián | C | St. Petersburg Thunder | 28 | 12/15/2013 | Terrytown | USA | Right | Right | 5' 11" | 220 lbs | - |
| Sánchez, Manuel | RP | Lancaster Farmers | 22 | 08/09/2019 | Guacimo | CRC | Right | Right | 6' 8" | 220 lbs | - |
| Sangrey, Thomas | RP | Atlantic City Sonics | 22 | 03/29/2019 | Madison | USA | Right | Right | 5' 10" | 175 lbs | - |
| Santos, Pablo | SS | Lake Minnetonka Love Boats | 25 | 02/15/2016 | San Vicente | SLV | Right | Right | 6' 1" | 195 lbs | - |
| Scribbner, Thom | 2B | Casper Ghosts | 25 | 11/21/2016 | Santa Cruz | USA | Right | Right | 6' 2" | 205 lbs | - |
| Seawright, John | SP | Northville Eclipse | 26 | 06/01/2015 | Kennebunk | USA | Switch | Right | 5' 11" | 190 lbs | - |
| Secada, Diego Alejandro | 1B | Northville Eclipse | 24 | 05/25/2017 | Desemparados | CRC | Switch | Right | 6' 5" | 235 lbs | - |
| Shannon, Robert | 1B | Lancaster Farmers | 21 | 07/08/2020 | Paradise | USA | Left | Right | 6' 0" | 200 lbs | - |
| Shepard, Dave | SP | Casper Ghosts | 28 | 06/08/2013 | Millcreek | USA | Left | Left | 6' 2" | 200 lbs | - |
| Shuo, Tso-lin | RF | Lake Minnetonka Love Boats | 26 | 02/22/2015 | Huinan | CHN | Left | Left | 5' 11" | 190 lbs | - |
| Smith, Robert | RP | Atlantic City Sonics | 28 | 04/02/2013 | New York | USA | Right | Right | 5' 11" | 200 lbs | - |
| Smith, Tim | RP | Lancaster Farmers | 24 | 03/17/2017 | Hiram | USA | Right | Right | 6' 0" | 190 lbs | - |
| Soisalo, Pellervo | SP | St. Petersburg Thunder | 28 | 10/16/2013 | Komadi | HUN | Left | Left | 6' 4" | 205 lbs | - |
| Solleveld, Olaf | RP | Virginia Beach Whales | 29 | 12/27/2012 | Barber | CUR | Right | Right | 6' 4" | 215 lbs | - |
| Sparks, John | SP | Northville Eclipse | 25 | 01/29/2016 | McHenry | USA | Right | Right | 6' 2" | 185 lbs | - |
| Srivastav, Abhipala | CF | Atlantic City Sonics | 24 | 05/08/2017 | Rohtak | IND | Right | Right | 6' 3" | 185 lbs | - |
| Starr, Jamie | 3B | Lake Minnetonka Love Boats | 24 | 10/26/2017 | Carolina | PUR | Left | Right | 6' 3" | 210 lbs | - |
| Stevens, John | RP | Virginia Beach Whales | 22 | 04/15/2019 | Porcupine | CAN | Right | Right | 6' 0" | 195 lbs | - |
| Stevens, Marvin | SP | Lancaster Farmers | 23 | 11/25/2018 | Maynardville | USA | Right | Right | 6' 5" | 225 lbs | - |
