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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sagastizabal, Salvador | RP | Bloomington Longnecks | 31 | 09/28/2010 | Cúcuta | COL | Right | Right | 6' 6" | 220 lbs | - |
| Sahagún, Júlio | 2B | Baton Rouge Brass | 21 | 11/23/2020 | El Estor | GUA | Right | Right | 6' 1" | 185 lbs | $280,000 |
| Sakata, Masaharu | RP | Port Royal Disaster | 33 | 03/22/2008 | Musashimurayama | JPN | Right | Right | 6' 2" | 205 lbs | $360,000 |
| Salazar, Paco | RP | Port Royal Disaster | 31 | 02/09/2010 | Clawson | USA | Left | Left | 6' 4" | 220 lbs | $4,000,000 |
| Sánchez, Carlos | C | Bloomington Longnecks | 26 | 11/08/2015 | Bay Point | USA | Left | Right | 6' 0" | 200 lbs | - |
| Sánchez, Manuel | RP | Bloomington Longnecks | 30 | 11/19/2011 | Songo-La Maya | CUB | Left | Right | 6' 0" | 215 lbs | - |
| Sanders, Bob | RF | Baton Rouge Brass | 30 | 09/07/2011 | Kansas City | USA | Left | Left | 5' 10" | 190 lbs | - |
| Sastre, Luis | SP | Bloomington Longnecks | 23 | 06/03/2018 | La Mata | DOM | Right | Right | 6' 5" | 205 lbs | $280,000 |
| Sawyer, Davis | SP | Bakersfield Nobles | 30 | 03/21/2011 | Shawnee | USA | Right | Right | 6' 5" | 230 lbs | $2,460,000 |
| Scanlan, Oakland | CL | Forest City Warriors | 27 | 06/08/2014 | Salem | USA | Right | Right | 6' 8" | 250 lbs | - |
| Schaefer, John | LF | Bloomington Longnecks | 33 | 03/19/2008 | Cincinnati | USA | Left | Left | 6' 2" | 240 lbs | - |
| Scott, Cody | SS | Bloomington Longnecks | 25 | 04/25/2016 | Thomasville | USA | Right | Right | 6' 1" | 190 lbs | - |
| Seco, Javier | 1B | Baton Rouge Brass | 27 | 08/01/2014 | Changuinola | PAN | Left | Left | 6' 3" | 225 lbs | $3,400,000 |
| Shamakani, Dean | CF | Baton Rouge Brass | 24 | 07/06/2017 | George | RSA | Right | Right | 6' 3" | 200 lbs | $280,000 |
| Shamburger, Turner | RP | Bakersfield Nobles | 30 | 08/05/2011 | Bronx | USA | Right | Right | 6' 2" | 220 lbs | - |
| Shao, Dou-guan | SP | Jersey City Tritons | 29 | 11/10/2012 | Chungli | TPE | Right | Right | 6' 2" | 190 lbs | - |
| Sheffield, Charles | 2B | Bloomington Longnecks | 25 | 11/11/2016 | Pueblo | USA | Right | Right | 6' 2" | 210 lbs | - |
| Silva, David | SP | Baton Rouge Brass | 27 | 03/19/2014 | Las Palmas | ESP | Right | Right | 6' 2" | 195 lbs | $280,000 |
| Silva, Miguel | C | Memphis Redbirds | 26 | 09/08/2015 | Manicaragua | CUB | Right | Right | 6' 1" | 215 lbs | - |
| Simic, Pavle | RP | Bakersfield Nobles | 28 | 06/10/2013 | Botevgrad | BUL | Right | Left | 6' 7" | 220 lbs | - |
| Slooters, Peer | SP | Bakersfield Nobles | 23 | 01/10/2018 | Willemstad | CUR | Right | Right | 6' 4" | 185 lbs | $280,000 |
| Snider, David | C | Jersey City Tritons | 29 | 06/06/2012 | Cordova | USA | Right | Right | 5' 11" | 190 lbs | - |
| Speranza, Paolo | RP | Memphis Redbirds | 25 | 10/30/2016 | Valencia | VEN | Switch | Left | 5' 10" | 180 lbs | - |
| Spirk, Kliment | RP | Texas Bronze Sox | 30 | 04/19/2011 | Ceska Kamenice | CZE | Right | Right | 6' 1" | 195 lbs | - |
| Stanley, José | RP | Memphis Redbirds | 25 | 05/11/2016 | Corvallis | USA | Right | Right | 6' 11" | 265 lbs | - |
| Stevenson, Shawn | RP | Free Agent | 31 | 03/15/2010 | Camden | USA | Right | Right | 6' 6" | 230 lbs | - |
| Stokes, Lawrence | 1B | Forest City Warriors | 30 | 04/12/2011 | Savannah | USA | Right | Right | 6' 4" | 220 lbs | $280,000 |
| Swanson, Jacob | RP | Bakersfield Nobles | 29 | 08/13/2012 | Storrs | USA | Right | Right | 6' 2" | 210 lbs | - |
