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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sáenz, Ramón | SP | Long Island Lighthouse | 19 | 03/06/2022 | Tenares | DOM | Right | Right | 6' 4" | 190 lbs | - |
| Salazar, Zacarías | SS | Colorado Billy Goats | 25 | 02/27/2016 | San Luis Potosí | MEX | Right | Right | 6' 1" | 190 lbs | $350,000 |
| Salcido, Pedro | SP | Thunder Bay Northern Lions BC | 16 | 05/19/2025 | Cot | CRC | Right | Right | 6' 1" | 170 lbs | - |
| Sandoval, César | SP | D.C. Divided | 28 | 08/28/2013 | Sancti Spíritus | CUB | Right | Right | 6' 2" | 195 lbs | $1,187,500 |
| Sang, Yang-cheng | SP | Long Island Lighthouse | 19 | 03/05/2022 | Liaoyuan | CHN | Left | Left | 6' 6" | 210 lbs | - |
| Santángel, Juan | LF | Nashville Outlaws | 22 | 07/15/2019 | Panama | PAN | Left | Left | 6' 1" | 170 lbs | $280,000 |
| Saraf, Barsati | SS | Buckhead Bowties | 25 | 04/28/2016 | Springs | RSA | Right | Right | 5' 11" | 190 lbs | $4,800,000 |
| Sarcoma, Broderick | 2B | Nashville Outlaws | 27 | 08/13/2014 | Mayagüez | PUR | Right | Right | 5' 10" | 180 lbs | $1,625,000 |
| Schneider, Jared | 2B | Buckhead Bowties | 23 | 04/22/2018 | Tempe | USA | Left | Right | 6' 2" | 185 lbs | $280,000 |
| Schrattenthaler, David | SP | Thunder Bay Northern Lions BC | 22 | 02/02/2019 | Robbinsdale | USA | Switch | Right | 6' 0" | 180 lbs | $280,000 |
| Scots, Tom | RP | Ft. Worth Cattlemen | 30 | 01/21/2011 | Jacksonville | USA | Right | Right | 6' 8" | 235 lbs | $470,000 |
| Segura, Jorge | 1B | Hollywood Shredders | 19 | 12/31/2022 | Santo Domingo | DOM | Right | Right | 6' 3" | 210 lbs | - |
| Sharts, Owen | RF | Las Vegas Flamingos | 32 | 08/14/2009 | Simi Valley | USA | Left | Left | 6' 0" | 215 lbs | $550,000 |
| Shill, Marcus | LF | Buckhead Bowties | 29 | 11/01/2012 | Port Antonio | JAM | Left | Right | 6' 1" | 195 lbs | $12,100,000 |
| Shinn, Chan-ho | 3B | Las Vegas Flamingos | 23 | 02/02/2018 | Incheon | KOR | Left | Right | 6' 2" | 205 lbs | $10,000,000 |
| Shkurin, Jeirgif | RF | Vancouver Grey Wolves | 17 | 04/01/2024 | Skuodas | LTU | Right | Left | 6' 4" | 195 lbs | - |
| Shmerkin, Yaakov | LF | San Mateo Dirty Reds | 26 | 01/20/2015 | Arara-BaNegev | ISR | Right | Right | 5' 10" | 190 lbs | $280,000 |
| Sierra, Javier | LF | Nashville Outlaws | 32 | 09/11/2009 | Florida | CUB | Right | Left | 6' 6" | 230 lbs | $28,560,000 |
| Sifuentes, Esteban | RF | San Mateo Dirty Reds | 20 | 03/21/2021 | Mexico City | MEX | Left | Left | 6' 2" | 175 lbs | $280,000 |
| Silva, Jesús | SP | Greenville 84s | 27 | 06/15/2014 | Newbury | USA | Right | Right | 6' 6" | 220 lbs | $280,000 |
| Silva, José | C | St. Louis Coeur | 19 | 08/03/2022 | Cunco | CHI | Right | Right | 6' 5" | 225 lbs | - |
| Singh, Soshal Distan | 2B | Ft. Worth Cattlemen | 18 | 06/27/2023 | Bangalore | IND | Right | Right | 6' 0" | 165 lbs | - |
| Sison, Jim | RP | Ft. Worth Cattlemen | 34 | 05/15/2007 | Manton | USA | Right | Right | 6' 1" | 220 lbs | $1,200,000 |
| Sol, Je-ju | CF | Cleveland Browns | 18 | 05/23/2023 | Jeongeup | KOR | Right | Right | 6' 0" | 170 lbs | - |
| Soto, Bartolo | RF | Nashville Outlaws | 32 | 09/07/2009 | Puerto Plata | DOM | Left | Left | 6' 2" | 230 lbs | $6,500,000 |
| Soto, Emílio | CF | San Mateo Dirty Reds | 17 | 10/22/2024 | Cajamarca | PER | Right | Right | 6' 0" | 170 lbs | - |
| Soto, Jaime | 2B | St. Louis Coeur | 26 | 12/20/2015 | Santiago | CHI | Right | Right | 6' 1" | 195 lbs | $6,000,000 |
| Souza, Jorge | SP | Thunder Bay Northern Lions BC | 21 | 09/01/2020 | Villa Vazquez | DOM | Right | Right | 6' 1" | 185 lbs | - |
| Stanley, Forest | SP | Nashville Outlaws | 31 | 06/27/2010 | Bartlesville | USA | Switch | Right | 6' 3" | 215 lbs | $7,550,000 |
| Stanton, Bill | 1B | Colorado Billy Goats | 27 | 10/10/2014 | Little Canada | USA | Left | Left | 6' 5" | 230 lbs | $280,000 |
| Stinchcombe, Gerard | SP | San Mateo Dirty Reds | 18 | 04/17/2023 | London | ENG | Left | Left | 5' 10" | 170 lbs | - |
| Stroo, Nees | RP | Greenville 84s | 33 | 09/23/2008 | Oranjestad | ARU | Left | Left | 6' 4" | 245 lbs | $900,000 |
| Stuterberg, Harry | SP | Colorado Billy Goats | 31 | 10/06/2010 | New York | USA | Right | Right | 6' 2" | 205 lbs | $945,000 |
| Suggett, Glenn | SP | Greenville 84s | 26 | 09/27/2015 | Los Angeles | USA | Right | Right | 6' 1" | 195 lbs | $280,000 |
| Suhendro, Jefferson | RP | Free Agent | 32 | 05/18/2009 | Sampang | IDN | Right | Right | 6' 0" | 170 lbs | - |
| Surtees, Albert | SP | Colorado Billy Goats | 17 | 08/24/2024 | Oldham | ENG | Right | Right | 6' 7" | 205 lbs | - |
