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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sahar, Anathapinda | SP | Galesburg Guzzlers | 20 | 04/06/2021 | Shohratgarh | IND | Right | Left | 6' 2" | 185 lbs | - |
| Saito, Sen | RP | South Beach Blaze | 19 | 03/11/2022 | Hachioji | JPN | Left | Left | 6' 1" | 175 lbs | - |
| Salas, José | 2B | Chicago Tula | 22 | 06/30/2019 | Dajabón | DOM | Right | Right | 6' 0" | 180 lbs | - |
| Sánchez, José | 1B | Kent Comets | 24 | 10/14/2017 | Nicoya | CRC | Right | Right | 6' 2" | 195 lbs | - |
| Sánchez, Leonardo | SP | Kent Comets | 22 | 07/13/2019 | North Decatur | USA | Left | Right | 6' 0" | 180 lbs | - |
| Sandín, Mauro | SP | Cut Off Crawdads | 23 | 11/21/2018 | Santiago | CRC | Right | Right | 6' 4" | 200 lbs | - |
| Sanz, Héctor | SP | Cut Off Crawdads | 23 | 05/30/2018 | Constanza | DOM | Left | Left | 6' 2" | 190 lbs | - |
| Saromi, Sekien | CL | Chicago Tula | 21 | 07/20/2020 | Narashino | JPN | Right | Right | 6' 3" | 190 lbs | - |
| Sawyer, John | RP | Rocky Mountain Vibes | 24 | 06/10/2017 | Lehi | USA | Left | Left | 6' 2" | 190 lbs | - |
| Schweitzer, Laurent | SP | Chicago Gold Sox | 21 | 09/16/2020 | Toronto | CAN | Left | Right | 6' 3" | 200 lbs | - |
| Sedlaczek, Vratislav | SP | Lake Erie Arryns | 23 | 11/01/2018 | Svitavy | CZE | Switch | Right | 6' 6" | 200 lbs | - |
| Semprún, Ramón | 2B | Rocky Mountain Vibes | 22 | 07/29/2019 | Catia La Mar | VEN | Right | Right | 5' 11" | 190 lbs | - |
| Shelley, Erwin | SP | Rocky Mountain Vibes | 23 | 08/25/2018 | Montreal | CAN | Right | Right | 6' 3" | 200 lbs | - |
| Shimizu, Yoshiki | RF | South Beach Blaze | 20 | 01/26/2021 | Ofunato | JPN | Right | Right | 6' 2" | 180 lbs | - |
| Shive, Fredrick | RP | Kent Comets | 23 | 09/19/2018 | North Ogden | USA | Right | Right | 6' 1" | 190 lbs | - |
| Sierra, Juan | 2B | Rocky Mountain Vibes | 24 | 04/20/2017 | Rolling Hills Estates | USA | Right | Right | 6' 4" | 215 lbs | - |
| Sims, Bob | 3B | Lake Erie Arryns | 24 | 06/02/2017 | Hamilton | USA | Right | Right | 6' 1" | 195 lbs | - |
| Situ, Zee-loo | 2B | South Beach Blaze | 20 | 06/25/2021 | Shijiazhuang | CHN | Right | Right | 6' 1" | 175 lbs | - |
| Smith, Dan | RP | South Beach Blaze | 20 | 02/21/2021 | Somers Point | USA | Right | Right | 6' 0" | 175 lbs | - |
| Soriano, José | C | Galesburg Guzzlers | 22 | 07/31/2019 | Juigalpa | NCA | Right | Right | 6' 0" | 190 lbs | - |
| Sosa, Armando | SP | Chicago Gold Sox | 24 | 12/14/2017 | Santiago | CHI | Right | Right | 6' 0" | 180 lbs | - |
| Soto, Rafael | 3B | Free Agent | 21 | 01/05/2020 | Villa Alemana | CHI | Left | Right | 5' 9" | 170 lbs | - |
| Sousa, Jim | SP | Rocky Mountain Vibes | 23 | 04/07/2018 | Bordentown | USA | Right | Right | 6' 1" | 180 lbs | - |
| St. John, Daniel | RP | Galesburg Guzzlers | 21 | 09/08/2020 | Concord | USA | Switch | Right | 6' 1" | 185 lbs | - |
| Stephens, Phil | SP | Chicago Gold Sox | 22 | 01/05/2019 | Whitney | USA | Right | Left | 5' 10" | 180 lbs | - |
| Sugimoto, Kuniyuki | SP | Cut Off Crawdads | 21 | 02/15/2020 | Toyonaka | JPN | Right | Right | 6' 3" | 195 lbs | - |
| Sun, Ching | 3B | Galesburg Guzzlers | 20 | 04/07/2021 | Taipei | TPE | Right | Right | 5' 10" | 175 lbs | - |
| Surgener, Richard | RP | Tennessee Smokies | 19 | 01/11/2022 | Oceanside | USA | Right | Right | 6' 2" | 180 lbs | - |
| Suzuarregui, Ramón | SS | Kent Comets | 19 | 01/25/2022 | Managua | NCA | Right | Right | 5' 11" | 160 lbs | - |
| Szymanski, Aloysius | 1B | Lake Erie Arryns | 23 | 05/22/2018 | Milwaukee | USA | Right | Right | 6' 7" | 240 lbs | - |
