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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sackett, Mike | 2B | Amarillo Submarinos | 19 | 06/30/2021 | Chicago | USA | Right | Right | 5' 9" | 160 lbs | - |
| Saelices, Ángel | SS | Greenport Harbor Whales | 20 | 02/10/2020 | Santo Domingo | DOM | Right | Right | 5' 9" | 150 lbs | - |
| Sainz, Eduardo | C | Watford City Trash Pandas | 20 | 11/06/2020 | Santa Ana | CRC | Right | Right | 6' 0" | 190 lbs | - |
| Saksansin, Poom | SP | Greenport Harbor Whales | 20 | 10/07/2020 | Chiang Khong | THA | Right | Right | 6' 3" | 190 lbs | - |
| Salgado, Alonso | LF | Maine Sea Dogs | 21 | 03/03/2019 | Vernon | USA | Right | Right | 6' 3" | 200 lbs | - |
| Samelo, Bayani | RP | Ladue Rams | 19 | 03/10/2021 | Iloilo | PHI | Right | Right | 6' 2" | 180 lbs | - |
| Sandoval, César | SP | Bethlehem Angel Kitties | 20 | 07/28/2020 | Santiago de Cuba | CUB | Right | Right | 6' 7" | 220 lbs | - |
| Santos, José | SP | Bethlehem Angel Kitties | 20 | 09/08/2020 | San Rafael Abajo | CRC | Right | Right | 6' 3" | 175 lbs | - |
| Sapinoso, Juan | RF | Maine Sea Dogs | 18 | 05/27/2022 | Puerto Plata | DOM | Left | Left | 6' 1" | 180 lbs | - |
| Sato, Tsugumichi | CF | Canonniers de Quebec | 21 | 05/23/2019 | Kitakyushu | JPN | Right | Right | 6' 4" | 200 lbs | - |
| Shaw, Devin | SS | Capital Hill Interns | 20 | 08/24/2020 | Bay Harbor Islands | USA | Right | Right | 6' 0" | 180 lbs | - |
| Shepard, Colton | C | Northwest Territory Beavers | 20 | 02/01/2020 | Bensenville | USA | Right | Right | 6' 3" | 200 lbs | - |
| Shini, Kimitada | RP | Northwest Territory Beavers | 21 | 07/03/2019 | Kobe | JPN | Right | Right | 6' 2" | 185 lbs | - |
| Shipp, Cameron | RP | Amarillo Submarinos | 19 | 07/20/2021 | Anna's Retreat | VIR | Left | Left | 6' 5" | 190 lbs | - |
| Silva, Júlio | CF | Bompton Baby Lakers | 21 | 09/02/2019 | Gatún | PAN | Left | Left | 6' 2" | 185 lbs | - |
| Sinclair, Jacob | SP | Amarillo Submarinos | 20 | 09/26/2020 | Louisville | USA | Switch | Right | 6' 2" | 190 lbs | - |
| Siu, Zhao-ji | 3B | Athletic Club KC U-21 | 19 | 08/21/2021 | Hsinchu | TPE | Right | Right | 6' 2" | 190 lbs | - |
| Solís, Héctor | CF | Northwest Territory Beavers | 21 | 12/10/2019 | Santiago | CHI | Switch | Right | 6' 2" | 190 lbs | - |
| Solís, Vicente | SP | Athletic Club KC U-21 | 19 | 11/06/2021 | Claiborne | USA | Right | Right | 6' 0" | 175 lbs | - |
| Stafford, Zach | 3B | Northwest Territory Beavers | 20 | 01/20/2020 | Buffalo | USA | Right | Right | 6' 3" | 180 lbs | - |
| Stanisic, Dragoljub | RP | Watford City Trash Pandas | 20 | 02/20/2020 | Hisarja | BUL | Right | Right | 6' 1" | 175 lbs | - |
| Steel, Jim | SP | Ladue Rams | 19 | 12/01/2021 | Andover | USA | Left | Left | 6' 2" | 195 lbs | - |
| Steijn, Louis | RP | Free Agent | 19 | 08/05/2021 | Labadera | CUR | Right | Right | 6' 1" | 175 lbs | - |
| Stengel, Greg | SP | Germantown Uruguayans | 20 | 11/13/2020 | Bailey's Crossroads | USA | Left | Left | 6' 0" | 180 lbs | - |
| Stevenson, Arthur | SP | Canonniers de Quebec | 20 | 10/09/2020 | Richland Center | USA | Left | Left | 6' 4" | 205 lbs | - |
| Sturge, Keaton | CF | Bompton Baby Lakers | 19 | 04/22/2021 | Fredericton | CAN | Right | Right | 6' 0" | 175 lbs | - |
| Swetnam, Edward | RP | Amarillo Submarinos | 19 | 06/22/2021 | Charlotte Amalie | VIR | Right | Right | 6' 2" | 185 lbs | - |
