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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sacasas, Ernesto | C | Fort Knox Centennial | 19 | 10/05/2021 | Alotenango | GUA | Switch | Right | 6' 0" | 185 lbs | - |
| Salinas, Valerio | C | Hicksville Hounds | 20 | 01/18/2020 | Caracas | VEN | Right | Right | 6' 3" | 200 lbs | - |
| Samuels, George | SS | Long Island Ducks | 19 | 10/28/2021 | Arnold | USA | Right | Right | 6' 2" | 185 lbs | - |
| Sánchez, Arturo | RP | Redwood Rhinos | 19 | 04/02/2021 | La Romana | DOM | Right | Right | 5' 11" | 165 lbs | - |
| Sánchez, Jorge | 3B | Tulsa Otters | 19 | 03/12/2021 | Santiago | DOM | Right | Right | 6' 5" | 205 lbs | - |
| Schmidt, Pete | LF | Surprise Shockers | 20 | 01/15/2020 | Sausalito | USA | Left | Left | 6' 1" | 190 lbs | - |
| Schultz, Johnny | RF | Redwood Rhinos | 19 | 12/26/2021 | New York | USA | Right | Left | 6' 4" | 190 lbs | - |
| Schweitzer, Laurent | SP | Indiana Lead Sox | 20 | 09/16/2020 | Toronto | CAN | Left | Right | 6' 3" | 195 lbs | - |
| Scott, Dave | SS | Fort Knox Centennial | 20 | 10/31/2020 | New York | USA | Switch | Right | 6' 0" | 170 lbs | - |
| Sedlaczek, Vratislav | SP | Hicksville Hounds | 22 | 11/01/2018 | Svitavy | CZE | Switch | Right | 6' 6" | 200 lbs | - |
| Semprún, Carlos | SP | Memphis Music | 20 | 03/04/2020 | Santo Domingo | DOM | Left | Left | 6' 4" | 195 lbs | - |
| Semprún, Ramón | 2B | Long Island Ducks | 21 | 07/29/2019 | Catia La Mar | VEN | Right | Right | 5' 11" | 180 lbs | - |
| Serrano, Adrián | C | Redwood Rhinos | 18 | 04/07/2022 | San Pedro de Macorís | DOM | Right | Right | 6' 0" | 185 lbs | - |
| Shepherd, Alan | SS | Crowley Cajuns | 20 | 07/06/2020 | Arlington | USA | Right | Right | 6' 3" | 185 lbs | - |
| Shiu, Xie-li | 2B | Indiana Lead Sox | 21 | 08/09/2019 | Taichung | TPE | Left | Right | 6' 1" | 180 lbs | - |
| Short, Lindsay | SS | Tulsa Otters | 19 | 05/26/2021 | North Potomac | USA | Right | Right | 5' 10" | 155 lbs | - |
| Silva, Luis | RP | Fort Knox Centennial | 18 | 08/09/2022 | Mexico City | MEX | Left | Left | 6' 0" | 170 lbs | - |
| Simmons, Lance | SP | Hudsonville Flanderses | 21 | 09/20/2019 | Sunnyvale | USA | Left | Left | 6' 1" | 180 lbs | - |
| Simpson, John | 3B | Hudsonville Flanderses | 19 | 11/02/2021 | Memphis | USA | Right | Right | 5' 11" | 170 lbs | - |
| Sims, Nick | C | Surprise Shockers | 20 | 12/09/2020 | Hackensack | USA | Right | Right | 6' 2" | 205 lbs | - |
| Situ, Zee-loo | 2B | Fort Knox Centennial | 19 | 06/25/2021 | Shijiazhuang | CHN | Right | Right | 6' 1" | 175 lbs | - |
| Smiley, Ray | SP | Memphis Music | 20 | 12/11/2020 | Youngstown | USA | Right | Left | 6' 2" | 195 lbs | - |
| Smith, Dan | RP | Fort Knox Centennial | 19 | 02/21/2021 | Somers Point | USA | Right | Right | 6' 0" | 175 lbs | - |
| Soria, Ánibal | LF | Crowley Cajuns | 19 | 08/22/2021 | Concepción | CHI | Right | Right | 6' 5" | 195 lbs | - |
| Soriano, José | C | Memphis Music | 21 | 07/31/2019 | Juigalpa | NCA | Right | Right | 6' 0" | 190 lbs | - |
| Soto, Alonso | RP | Indiana Lead Sox | 21 | 12/27/2019 | Ayapa | HON | Left | Left | 6' 4" | 185 lbs | - |
| Sprengel, Guonçalle | SS | Redwood Rhinos | 17 | 03/01/2023 | Carúpano | VEN | Right | Right | 6' 1" | 175 lbs | - |
| Sprinkle, Andrew | 3B | Hudsonville Flanderses | 20 | 04/14/2020 | New Orleans | USA | Right | Right | 6' 1" | 185 lbs | - |
| Stavely, Dylan | CF | Memphis Music | 19 | 06/17/2021 | Charlotte Amalie | VIR | Right | Right | 6' 2" | 170 lbs | - |
| Steele, Jim | C | Free Agent | 22 | 04/08/2018 | Mesquite | USA | Right | Right | 6' 1" | 200 lbs | - |
| Steele, Willie | RP | Surprise Shockers | 20 | 06/09/2020 | Denver | USA | Left | Right | 6' 0" | 180 lbs | - |
| Stensel, Krystof | RP | Crowley Cajuns | 19 | 05/20/2021 | Brno | CZE | Right | Right | 6' 8" | 205 lbs | - |
| Steur, Vaclav | 1B | Hicksville Hounds | 20 | 12/23/2020 | Oranjestad | ARU | Right | Right | 6' 6" | 225 lbs | - |
| Stevenson, Charles | SS | Memphis Music | 18 | 03/08/2022 | Plano | USA | Right | Right | 6' 0" | 170 lbs | - |
| Sugimoto, Kuniyuki | SP | Crowley Cajuns | 20 | 02/15/2020 | Toyonaka | JPN | Right | Right | 6' 3" | 195 lbs | - |
| Sun, Ching | 3B | Memphis Music | 19 | 04/07/2021 | Taipei | TPE | Right | Right | 5' 10" | 170 lbs | - |
