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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sagastizabal, Salvador | RP | Bloomington Longnecks | 30 | 09/28/2010 | Cúcuta | COL | Right | Right | 6' 6" | 220 lbs | - |
| Sakata, Masaharu | RP | Free Agent | 32 | 03/22/2008 | Musashimurayama | JPN | Right | Right | 6' 2" | 205 lbs | - |
| Sánchez, Carlos | C | Bloomington Longnecks | 25 | 11/08/2015 | Bay Point | USA | Left | Right | 6' 0" | 200 lbs | - |
| Sánchez, Manuel | RP | Bloomington Longnecks | 29 | 11/19/2011 | Songo-La Maya | CUB | Left | Right | 6' 0" | 215 lbs | - |
| Sarkies, Rod | 1B | Baton Rouge Brass | 23 | 06/27/2017 | Canberra | AUS | Right | Right | 6' 3" | 210 lbs | $280,000 |
| Scott, Cody | SS | Bloomington Longnecks | 24 | 04/25/2016 | Thomasville | USA | Right | Right | 6' 1" | 185 lbs | - |
| Seals, Albert | LF | Baton Rouge Brass | 27 | 05/28/2013 | Coral Springs | USA | Right | Right | 6' 1" | 215 lbs | - |
| Serna, Ricardo | RF | Jersey City Tritons | 25 | 03/21/2015 | Maracaibo | VEN | Switch | Right | 6' 4" | 215 lbs | - |
| Seth, Sadiya | RF | Bakersfield Nobles | 23 | 03/31/2017 | Bafata | GNB | Right | Left | 5' 11" | 175 lbs | - |
| Shamakani, Dean | CF | Baton Rouge Brass | 23 | 07/06/2017 | George | RSA | Right | Right | 6' 3" | 195 lbs | $280,000 |
| Shamburger, Turner | RP | Bakersfield Nobles | 29 | 08/05/2011 | Bronx | USA | Right | Right | 6' 2" | 215 lbs | - |
| Shao, Dou-guan | SP | Jersey City Tritons | 28 | 11/10/2012 | Chungli | TPE | Right | Right | 6' 2" | 190 lbs | - |
| Shortall, Rod | CF | Sacramento Redlegs | 30 | 12/01/2010 | Saint-Jérôme | CAN | Right | Right | 6' 1" | 195 lbs | - |
| Silva, David | RP | Baton Rouge Brass | 26 | 03/19/2014 | Las Palmas | ESP | Right | Right | 6' 2" | 195 lbs | $280,000 |
| Simic, Pavle | RP | Bakersfield Nobles | 27 | 06/10/2013 | Botevgrad | BUL | Right | Left | 6' 7" | 220 lbs | - |
| Slooters, Peer | SP | Bakersfield Nobles | 22 | 01/10/2018 | Willemstad | CUR | Right | Right | 6' 4" | 185 lbs | $280,000 |
| Snider, David | C | Jersey City Tritons | 28 | 06/06/2012 | Cordova | USA | Right | Right | 5' 11" | 195 lbs | - |
| Solís, Jeff | 1B | Bloomington Longnecks | 30 | 07/19/2010 | Collinsville | USA | Right | Right | 5' 10" | 195 lbs | $6,000,000 |
| Soriano, José | CF | Baton Rouge Brass | 26 | 05/11/2014 | Palos Heights | USA | Left | Left | 6' 1" | 195 lbs | $280,000 |
| Soto, Felipe | RF | Alaskan Humpbacks | 29 | 06/06/2011 | Buenos Aires | ARG | Left | Left | 6' 3" | 225 lbs | - |
| Soto, Ismael | RF | Sacramento Redlegs | 26 | 10/28/2014 | New York | USA | Left | Left | 6' 5" | 215 lbs | - |
| Soto, Phil | RP | Port Royal Disaster | 25 | 07/26/2015 | Long Beach | USA | Right | Right | 6' 4" | 205 lbs | $280,000 |
| Spirk, Kliment | CL | Texas Bronze Sox | 29 | 04/19/2011 | Ceska Kamenice | CZE | Right | Right | 6' 1" | 195 lbs | - |
| Spry, Julius | RP | Sacramento Redlegs | 26 | 10/13/2014 | Boston | USA | Right | Left | 6' 2" | 200 lbs | - |
| Sterk, Erik | 2B | Alaskan Humpbacks | 34 | 07/02/2006 | Phoenix | USA | Right | Right | 6' 1" | 240 lbs | - |
| Stottlar, Blaine | RP | Bakersfield Nobles | 34 | 08/10/2006 | Gleed | USA | Switch | Right | 6' 4" | 230 lbs | - |
| Stroud, Shaun | SP | Jersey City Tritons | 26 | 06/05/2014 | Anna's Retreat | VIR | Switch | Right | 6' 5" | 220 lbs | - |
| Subramanya, Cakaraka | SP | Jersey City Tritons | 23 | 01/13/2017 | Koyampattur | IND | Switch | Right | 6' 5" | 185 lbs | - |
| Suzuki, Takahiro | SS | Texas Bronze Sox | 30 | 12/13/2010 | Osaka | JPN | Left | Right | 6' 2" | 210 lbs | $280,000 |
| Svendsen, Aksel | SP | Baton Rouge Brass | 30 | 12/25/2010 | Sřnder Omme | DEN | Right | Right | 6' 1" | 195 lbs | - |
| Swartwood, Breanainn | SS | Texas Bronze Sox | 34 | 11/12/2006 | Tuscaloosa | USA | Right | Right | 6' 2" | 215 lbs | - |
